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Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates.

Andersson MK, Thorpe M, Hellman L.

FEBS J. 2010 May;277(10):2255-67. doi: 10.1111/j.1742-4658.2010.07642.x.


Extended substrate specificity of opossum chymase--implications for the origin of mast cell chymases.

Reimer JM, Enoksson M, Samollow PB, Hellman L.

Mol Immunol. 2008 Apr;45(7):2116-25. Epub 2007 Nov 19.


The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.

Andersson MK, Enoksson M, Gallwitz M, Hellman L.

Int Immunol. 2009 Jan;21(1):95-104. doi: 10.1093/intimm/dxn128. Epub 2008 Dec 10.


Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity.

Karlson U, Pejler G, Tomasini-Johansson B, Hellman L.

J Biol Chem. 2003 Oct 10;278(41):39625-31. Epub 2003 Aug 4.


Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors.

Ahooghalandari P, Hanke N, Thorpe M, Witte A, Messinger J, Hellman L.

PLoS One. 2013 Jun 19;8(6):e65988. Print 2013.


Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse-high specificity indicates high substrate selectivity.

Andersson MK, Pemberton AD, Miller HR, Hellman L.

Mol Immunol. 2008 May;45(9):2548-58. doi: 10.1016/j.molimm.2008.01.012. Epub 2008 Mar 3.


The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase.

Gallwitz M, Enoksson M, Thorpe M, Ge X, Hellman L.

Int Immunol. 2010 Jun;22(6):421-31. doi: 10.1093/intimm/dxq021. Epub 2010 Mar 25.


Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis.

Le Bonniec BF, Myles T, Johnson T, Knight CG, Tapparelli C, Stone SR.

Biochemistry. 1996 Jun 4;35(22):7114-22.


Rodent alpha-chymases are elastase-like proteases.

Kunori Y, Koizumi M, Masegi T, Kasai H, Kawabata H, Yamazaki Y, Fukamizu A.

Eur J Biochem. 2002 Dec;269(23):5921-30.


Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping.

Lambert MH, Blackburn RK, Seaton TD, Kassel DB, Kinder DS, Leesnitzer MA, Bickett DM, Warner JR, Andersen MW, Badiang JG, Cowan DJ, Gaul MD, Petrov KG, Rabinowitz MH, Wiethe RW, Becherer JD, McDougald DL, Musso DL, Andrews RC, Moss ML.

Comb Chem High Throughput Screen. 2005 Jun;8(4):327-39.


Biochemical characterization of prostasin, a channel activating protease.

Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):953-63.


Kinetic and modeling studies of S3-S3' subsites of HIV proteinases.

Tözsér J, Weber IT, Gustchina A, Bláha I, Copeland TD, Louis JM, Oroszlan S.

Biochemistry. 1992 May 26;31(20):4793-800.


Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

Li J, Lim SP, Beer D, Patel V, Wen D, Tumanut C, Tully DC, Williams JA, Jiricek J, Priestle JP, Harris JL, Vasudevan SG.

J Biol Chem. 2005 Aug 5;280(31):28766-74. Epub 2005 Jun 1.


Distinct multisite synergistic interactions determine substrate specificities of human chymase and rat chymase-1 for angiotensin II formation and degradation.

Sanker S, Chandrasekharan UM, Wilk D, Glynias MJ, Karnik SS, Husain A.

J Biol Chem. 1997 Jan 31;272(5):2963-8.


Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase.

Thorpe M, Yu J, Boinapally V, Ahooghalandari P, Kervinen J, Garavilla Ld, Hellman L.

Int Immunol. 2012 Dec;24(12):771-82. doi: 10.1093/intimm/dxs081. Epub 2012 Sep 4.


Functional characterization of the cleavage specificity of the sapovirus chymotrypsin-like protease.

Robel I, Gebhardt J, Mesters JR, Gorbalenya A, Coutard B, Canard B, Hilgenfeld R, Rohayem J.

J Virol. 2008 Aug;82(16):8085-93. doi: 10.1128/JVI.00693-08. Epub 2008 Jun 11.

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