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20408504,16274259,19149498,21381059,26084629,19503764,15139774,18777243,19487926,21883446,8894306,10851037,8608175,20412312,24783234,19037813,21416634,27413694,8312381,21793899,11390029,20463577,16388826,2758030,22436026,14608877,8571853,21048433,2742866,21707516,20486899,3801649,3205065,2763816,20085487,19534670,18850540,3814630,1399426,12518238,20515735,16939459,3702587,15588519,8690033,9133255,18451530,4041596,3778973,33917258,12001824,30830501,17162928,25524476,4090373,698889,25305576,11294009,15370367,1315709,8577465,19719805,3604133,15500819,30045674,3697487,19081783,20656726,1321312,27472261,15500827,33310056,19084592,28446133,7559922,26372004,34192628,2278235,19088495,18191834,9501865,25643848,6317286,8026802,3955083,10617774,15636220,9878221,32931824,8389342,6360540,25668941,3756234,8282033,11341748,8405186,2387688,18403084,16175371,11384152,21850163,23280361,23387882,19898641,31535344,16639622,18490958,18617164,22934629,11278611,32968091,24940038,21897744,18385793,26545319,4020298,20806081,20012886,31595373,2010693,27373973,32814140,11726630,34708633,24097121,18184874,10590006,31348666,29604281,32644679,23644096,19956561,34297243,20863274,23534693,34648773,32509875,22393276,34403214,35673411,30278157,22728317,35392749,24894799,34286494,20888812,20057910,35508906,24319329,31154035,31369034,32827359,32285142,36196296,32453849,18708625,24815519,21179241,24910283,35163997,31137834,24236935,31212142,22065920,24746615,26894964,34502323,31906919,24486794,7556479,15611105,31739645,33707565,3234180,36012010,21541328,32420594,32462803,33036381,34156426,33427852,22363833,27803872,33594935,20846136,36269652,36174677,21670697,21775657,32915983,32713071,24012988,32869287,36232595,36484206,35838084,34473602,30973281,1682222,32180680,35163178,27145928,23661155,32838548,33876553,34882206,34070168,36694206,24527449,20407021,2090399,35123994,31963166,23905084,26794210,9255513,16807531,35550196,21402586,24085193,22474428,9786852,24425853,33180800,31907674,18334943,24026512,20660107,7496982,32593252,12518039,31571074,34593413,33066702,29038122,21224996,36470534,31797406,31097153,30172102,21402587,34495288,36924513,35723573,36501043,29261974,34890705,31844034,35690384,21263052,36837692,3402067,33379411,31525139,20547889,31393016,23226398,19693292,34214668,19577582,34234627,31268450,18096063,33409916,1348055,21191720,36727354,28510099,37049610,34959281,20300521,36417410,31281592,35466599,24687817,31704338,25312851,33189813,24335070,32144529,27039707,10644699,22253484,21858719,32309636,22207480,28071717,30654434,24618482,12450448,21521442,35944665,32046582,34203836,26596277,30191330,19649315,22038221,32238695,26692723,24056539,5645039,28730112,29849449,24183661,30238191,32712251,30894486,31846211,8485395,36055924,32033321,31825152,36717496,32861760,20829639,34724220,33064904,35883773,36009235,10531368,23202388,25807637,36342707,34203479,16765571,18326726,36652491,35917999,24470212,35935143,18206663,36249298,31746523,34465795,35917497,29670833,35858321,30644339,34945026,30338158,33313297,31669043,34736070,34926465,29322749,32635523,21217865,21182720,24379787,34383612,36617712,19763765,18003120,31740631,34820309,34745744,33127826,34203367,37153694,33302741,32588698,36766820,21887096,36397720,35135707,33336073,22553556,36999595,33215336,24193350,35068477,32363741,28661002,24867291,32342818,35621284,33733956,31872467,36314870,31096723,36334639,22144771,34908799,24187660,34869210,32218152,8941046,35550168,34936061,31397734,34810099,29106797,8851625,34672064,34055894,36662053,34321408,23294769,31730524,28611546,36965272,33431985,8587022,35935793,33349225,34364038,34079667,31627438,31820737,36986851,26929595,33313289,26949638,23105378,33849365,32821051,30116630,36676026,32962301,32323615,36012695,30065652,34283505,32481272,25097467,21753902,30619846,31263410,31236344,6642663,36176273,30319911,21593426,21894448,28149770,32633667,30969521,32685729,26550213,29214051,28261099,33760524,32341868,35204279,36830827,29056677,35001064,31011480,19103200,34683990,31244509,33222086,37118843,37130710,35617652,30156422,34128434,26610533,28754903,24187484,31733041,36477544,24748782,21394267,35399464,36357454,36385982,35947134,23935827,18231610,33373717,33347109,22319229,34832933,31949726,24959303,25120344,30663344,33669740,34782111,35994266,33217969,29498484,35281296,32392157,36716847,36210413,24194638,23105864,19018298,27729797,36678523,31985990,36361545,37047290,34026791,27625879,19030757,24393552,32202758,21344628,32294928,32115992,33933646,23943686,27114699,35308736,31414472,36181780,36045926,18916654,32309676,33564635,23105440,32927681,29356473,36986811,29188084,33880412,32508625,35504271,14070989,36306423,10178626,36874487,36620720,24194112,34044855,33149973,32739195,32739183,35516401,32206608,26869755,34532149,29888128,23874063,24921002,34557362,36941479,34599192,7263065,36168419,36983992,34763579,33621147,23442334,35159492,28989288,31453001,23105695,31770163,23105286,26425385,34955608,20090202,33405805,27994437,34677208,33459458,310834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Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.

Babizhayev MA. Babizhayev MA. Drug Metabol Drug Interact. 2009;24(2-4):275-323. doi: 10.1515/dmdi.2009.24.2-4.275. Drug Metabol Drug Interact. 2009. PMID: 20408504

Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.

Babizhayev MA. Babizhayev MA. Drugs R D. 2005;6(6):345-69. doi: 10.2165/00126839-200506060-00004. Drugs R D. 2005. PMID: 16274259

State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.

Babizhayev MA, Kasus-Jacobi A. Babizhayev MA, et al. Curr Clin Pharmacol. 2009 Jan;4(1):4-37. doi: 10.2174/157488409787236074. Curr Clin Pharmacol. 2009. PMID: 19149498 Clinical Trial.

Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.

Babizhayev MA. Babizhayev MA. Cell Biochem Funct. 2011 Apr;29(3):183-206. doi: 10.1002/cbf.1737. Epub 2011 Mar 7. Cell Biochem Funct. 2011. PMID: 21381059

Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.

Babizhayev MA, Yegorov YE. Babizhayev MA, et al. Recent Pat Drug Deliv Formul. 2016;10(2):82-129. doi: 10.2174/1872211309666150618104657. Recent Pat Drug Deliv Formul. 2016. PMID: 26084629 Review.

N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.

Babizhayev MA, Burke L, Micans P, Richer SP. Babizhayev MA, et al. Clin Interv Aging. 2009;4():31-50. Epub 2009 May 14. Clin Interv Aging. 2009. PMID: 19503764 Free PMC article. Clinical Trial.

Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes.

Babizhayev MA, Deyev AI, Yermakova VN, Brikman IV, Bours J. Babizhayev MA, et al. Drugs R D. 2004;5(3):125-39. doi: 10.2165/00126839-200405030-00001. Drugs R D. 2004. PMID: 15139774 Review.

Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery.

Babizhayev MA. Babizhayev MA. Drug Dev Ind Pharm. 2008 Oct;34(10):1071-89. doi: 10.1080/03639040801958413. Drug Dev Ind Pharm. 2008. PMID: 18777243

N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.

Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A. Babizhayev MA, et al. Am J Ther. 2009 Nov-Dec;16(6):517-33. doi: 10.1097/MJT.0b013e318195e327. Am J Ther. 2009. PMID: 19487926 Clinical Trial.

Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.

Babizhayev MA. Babizhayev MA. Fundam Clin Pharmacol. 2012 Feb;26(1):86-117. doi: 10.1111/j.1472-8206.2011.00969.x. Epub 2011 Aug 24. Fundam Clin Pharmacol. 2012. PMID: 21883446 Review.

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