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HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the "test-and-treat" approach to reduce HIV transmission.

Novitsky V, Wang R, Bussmann H, Lockman S, Baum M, Shapiro R, Thior I, Wester C, Wester CW, Ogwu A, Asmelash A, Musonda R, Campa A, Moyo S, van Widenfelt E, Mine M, Moffat C, Mmalane M, Makhema J, Marlink R, Gilbert P, Seage GR 3rd, DeGruttola V, Essex M.

PLoS One. 2010 Apr 12;5(4):e10148. doi: 10.1371/journal.pone.0010148.


Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection.

Novitsky V, Ndung'u T, Wang R, Bussmann H, Chonco F, Makhema J, De Gruttola V, Walker BD, Essex M.

AIDS. 2011 Jul 31;25(12):1515-22. doi: 10.1097/QAD.0b013e3283471eb2.


Response to zidovudine/didanosine-containing combination antiretroviral therapy among HIV-1 subtype C-infected adults in Botswana: two-year outcomes from a randomized clinical trial.

Bussmann H, Wester CW, Thomas A, Novitsky V, Okezie R, Muzenda T, Gaolathe T, Ndwapi N, Mawoko N, Widenfelt E, Moyo S, Musonda R, Mine M, Makhema J, Moffat H, Essex M, Degruttola V, Marlink RG.

J Acquir Immune Defic Syndr. 2009 May 1;51(1):37-46. doi: 10.1097/QAI.0b013e31819ff102.


Viral load levels measured at set-point have risen over the last decade of the HIV epidemic in the Netherlands.

Gras L, Jurriaans S, Bakker M, van Sighem A, Bezemer D, Fraser C, Lange J, Prins JM, Berkhout B, de Wolf F; ATHENA National Observational Cohort Study.

PLoS One. 2009 Oct 7;4(10):e7365. doi: 10.1371/journal.pone.0007365.


Early antiretroviral therapy during primary HIV-1 infection results in a transient reduction of the viral setpoint upon treatment interruption.

Wyl Vv, Gianella S, Fischer M, Niederoest B, Kuster H, Battegay M, Bernasconi E, Cavassini M, Rauch A, Hirschel B, Vernazza P, Weber R, Joos B, Günthard HF; Swiss HIV Cohort Study-SHCS.

PLoS One. 2011;6(11):e27463. doi: 10.1371/journal.pone.0027463. Epub 2011 Nov 15.


Using HIV viral load to guide treatment-for-prevention interventions.

Novitsky V, Essex M.

Curr Opin HIV AIDS. 2012 Mar;7(2):117-24. doi: 10.1097/COH.0b013e32834fe8ff. Review.


Viral dynamics and CD4+ T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern Africa.

Gray CM, Williamson C, Bredell H, Puren A, Xia X, Filter R, Zijenah L, Cao H, Morris L, Vardas E, Colvin M, Gray G, McIntyre J, Musonda R, Allen S, Katzenstein D, Mbizo M, Kumwenda N, Taha T, Karim SA, Flores J, Sheppard HW.

AIDS Res Hum Retroviruses. 2005 Apr;21(4):285-91.


Plasma viral load in HIV-1 and HIV-2 singly and dually infected individuals in Guinea-Bissau, West Africa: significantly lower plasma virus set point in HIV-2 infection than in HIV-1 infection.

Andersson S, Norrgren H, da Silva Z, Biague A, Bamba S, Kwok S, Christopherson C, Biberfeld G, Albert J.

Arch Intern Med. 2000 Nov 27;160(21):3286-93.


Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group.

Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, Meehan MO, Lutalo T, Gray RH.

N Engl J Med. 2000 Mar 30;342(13):921-9.


Dried blood spot HIV-1 RNA quantification: a useful tool for viral load monitoring among HIV-infected individuals in India.

Neogi U, Gupta S, Rodridges R, Sahoo PN, Rao SD, Rewari BB, Shastri S, Costa AD, Shet A.

Indian J Med Res. 2012 Dec;136(6):956-62.


Estimation of the predictive role of plasma viral load on CD4 decline in HIV-1 subtype C-infected subjects in India.

Ding M, Tarwater P, Rodriguez M, Chatterjee R, Ratner D, Yamamura Y, Roy P, Mellors J, Neogi D, Chen Y, Gupta P.

J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):119-25. doi: 10.1097/QAI.0b013e3181911991.


Recent HIV-1 infection: identification of individuals with high viral load setpoint in a voluntary counselling and testing centre in rural Mozambique.

Serna-Bolea C, de Deus N, Acácio S, Muñoz J, Nhalungo D, Letang E, Alonso P, Naniche D.

PLoS One. 2012;7(2):e31859. doi: 10.1371/journal.pone.0031859. Epub 2012 Feb 21.


Time to viral load suppression in antiretroviral-naive and -experienced HIV-infected pregnant women on highly active antiretroviral therapy: implications for pregnant women presenting late in gestation.

Aziz N, Sokoloff A, Kornak J, Leva NV, Mendiola ML, Levison J, Feakins C, Shannon M, Cohan D.

BJOG. 2013 Nov;120(12):1534-47. doi: 10.1111/1471-0528.12226. Epub 2013 Aug 7.


Better control of early viral replication is associated with slower rate of elicited antiviral antibodies in the detuned enzyme immunoassay during primary HIV-1C infection.

Novitsky V, Wang R, Kebaabetswe L, Greenwald J, Rossenkhan R, Moyo S, Musonda R, Woldegabriel E, Lagakos S, Essex M.

J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):265-72. doi: 10.1097/QAI.0b013e3181ab6ef0.


Initial plasma HIV-1 RNA levels and progression to AIDS in women and men.

Sterling TR, Vlahov D, Astemborski J, Hoover DR, Margolick JB, Quinn TC.

N Engl J Med. 2001 Mar 8;344(10):720-5.


Viral load differences in early infection with two HIV-1 subtypes.

Hu DJ, Vanichseni S, Mastro TD, Raktham S, Young NL, Mock PA, Subbarao S, Parekh BS, Srisuwanvilai L, Sutthent R, Wasi C, Heneine W, Choopanya K.

AIDS. 2001 Apr 13;15(6):683-91.


Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.

Campbell MS, Kahle EM, Celum C, Lingappa JR, Kapiga S, Mujugira A, Mugo NR, Fife KH, Mullins JI, Baeten JM; Partners in Prevention HSV/HIV Transmission Study Team.

J Infect Dis. 2013 Apr;207(7):1166-70. doi: 10.1093/infdis/jit015. Epub 2013 Jan 11.


HIV RNA level in early infection is predicted by viral load in the transmission source.

Hecht FM, Hartogensis W, Bragg L, Bacchetti P, Atchison R, Grant R, Barbour J, Deeks SG.

AIDS. 2010 Apr 24;24(7):941-5. doi: 10.1097/QAD.0b013e328337b12e.


Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.

Touloumi G, Pantazis N, Pillay D, Paraskevis D, Chaix ML, Bucher HC, Kücherer C, Zangerle R, Kran AM, Porter K; CASCADE collaboration in EuroCoord.

Clin Infect Dis. 2013 Mar;56(6):888-97. doi: 10.1093/cid/cis1000. Epub 2012 Dec 7.

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