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Results: 1 to 20 of 119

Similar articles for PubMed (Select 20400861)

1.

The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions.

Harding FA, Stickler MM, Razo J, DuBridge RB.

MAbs. 2010 May-Jun;2(3):256-65. Epub 2010 May 1.

2.

SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity.

Gonzales NR, Padlan EA, De Pascalis R, Schuck P, Schlom J, Kashmiri SV.

Mol Immunol. 2004 Jul;41(9):863-72.

PMID:
15261458
3.

Minimizing the immunogenicity of antibodies for clinical application.

Gonzales NR, De Pascalis R, Schlom J, Kashmiri SV.

Tumour Biol. 2005 Jan-Feb;26(1):31-43. Review.

PMID:
15741769
4.

SDR grafting--a new approach to antibody humanization.

Kashmiri SV, De Pascalis R, Gonzales NR, Schlom J.

Methods. 2005 May;36(1):25-34. Review.

PMID:
15848072
5.

Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.

Hanf KJ, Arndt JW, Chen LL, Jarpe M, Boriack-Sjodin PA, Li Y, van Vlijmen HW, Pepinsky RB, Simon KJ, Lugovskoy A.

Methods. 2014 Jan 1;65(1):68-76. doi: 10.1016/j.ymeth.2013.06.024. Epub 2013 Jun 28.

PMID:
23816785
6.

Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody.

De Pascalis R, Iwahashi M, Tamura M, Padlan EA, Gonzales NR, Santos AD, Giuliano M, Schuck P, Schlom J, Kashmiri SV.

J Immunol. 2002 Sep 15;169(6):3076-84.

7.

Construction of a humanized antibody to hepatitis B surface antigen by specificity-determining residues (SDR)-grafting and de-immunization.

Kim KS, Kim HJ, Han BW, Myung PK, Hong HJ.

Biochem Biophys Res Commun. 2010 May 28;396(2):231-7. doi: 10.1016/j.bbrc.2010.04.071. Epub 2010 Apr 23.

PMID:
20399745
8.

Humanization by CDR grafting and specificity-determining residue grafting.

Kim JH, Hong HJ.

Methods Mol Biol. 2012;907:237-45. doi: 10.1007/978-1-61779-974-7_13.

PMID:
22907355
9.

Human-engineered monoclonal antibodies retain full specific binding activity by preserving non-CDR complementarity-modulating residues.

Studnicka GM, Soares S, Better M, Williams RE, Nadell R, Horwitz AH.

Protein Eng. 1994 Jun;7(6):805-14.

PMID:
7937712
10.

Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.

Wu H, Nie Y, Huse WD, Watkins JD.

J Mol Biol. 1999 Nov 19;294(1):151-62.

PMID:
10556035
11.

Use of human germline genes in a CDR homology-based approach to antibody humanization.

Hwang WY, Almagro JC, Buss TN, Tan P, Foote J.

Methods. 2005 May;36(1):35-42.

PMID:
15848073
12.

Humanized IgG1 and IgG4 anti-CD4 monoclonal antibodies: effects on lymphocytes in the blood, lymph nodes, and renal allografts in cynomolgus monkeys.

Mourad GJ, Preffer FI, Wee SL, Powelson JA, Kawai T, Delmonico FL, Knowles RW, Cosimi AB, Colvin RB.

Transplantation. 1998 Mar 15;65(5):632-41.

PMID:
9521196
13.

Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.

Finlay WJ, Cunningham O, Lambert MA, Darmanin-Sheehan A, Liu X, Fennell BJ, Mahon CM, Cummins E, Wade JM, O'Sullivan CM, Tan XY, Piche N, Pittman DD, Paulsen J, Tchistiakova L, Kodangattil S, Gill D, Hufton SE.

J Mol Biol. 2009 May 8;388(3):541-58. doi: 10.1016/j.jmb.2009.03.019. Epub 2009 Mar 13.

PMID:
19285987
14.

Humanization strategies for an anti-idiotypic antibody mimicking HIV-1 gp41.

Mader A, Kunert R.

Protein Eng Des Sel. 2010 Dec;23(12):947-54. doi: 10.1093/protein/gzq092. Epub 2010 Oct 30.

15.

Humanization of a mouse monoclonal antibody by CDR-grafting: the importance of framework residues on loop conformation.

Kettleborough CA, Saldanha J, Heath VJ, Morrison CJ, Bendig MM.

Protein Eng. 1991 Oct;4(7):773-83.

PMID:
1798701
16.

Effects of humanization and gene shuffling on immunogenicity and antigen binding of anti-TAG-72 single-chain Fvs.

Pavlinkova G, Colcher D, Booth BJ, Goel A, Wittel UA, Batra SK.

Int J Cancer. 2001 Dec 1;94(5):717-26.

PMID:
11745468
17.

Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies.

Kolbinger F, Saldanha J, Hardman N, Bendig MM.

Protein Eng. 1993 Nov;6(8):971-80.

PMID:
8309946
18.

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics.

De Groot AS, Terry F, Cousens L, Martin W.

Expert Rev Clin Pharmacol. 2013 Nov;6(6):651-62. doi: 10.1586/17512433.2013.835698. Review.

19.

Humanization of predicted T-cell epitopes reduces the immunogenicity of chimeric antibodies: new evidence supporting a simple method.

Roque-Navarro L, Mateo C, Lombardero J, Mustelier G, Fernández A, Sosa K, Morrison SL, Pérez R.

Hybrid Hybridomics. 2003 Aug;22(4):245-57.

PMID:
14511570
20.

Humanization of a highly stable single-chain antibody by structure-based antigen-binding site grafting.

Villani ME, Morea V, Consalvi V, Chiaraluce R, Desiderio A, Benvenuto E, Donini M.

Mol Immunol. 2008 May;45(9):2474-85. doi: 10.1016/j.molimm.2008.01.016. Epub 2008 Mar 3.

PMID:
18313757
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