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Items: 1 to 20 of 177

1.

New developments in the discovery of small molecule Hedgehog pathway antagonists.

Tremblay MR, McGovern K, Read MA, Castro AC.

Curr Opin Chem Biol. 2010 Jun;14(3):428-35. doi: 10.1016/j.cbpa.2010.03.016.

PMID:
20399136
2.

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.

Tremblay MR, Nesler M, Weatherhead R, Castro AC.

Expert Opin Ther Pat. 2009 Aug;19(8):1039-56. doi: 10.1517/13543770903008551. Review.

PMID:
19505195
3.

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics.

Peukert S, Miller-Moslin K.

ChemMedChem. 2010 Apr 6;5(4):500-12. doi: 10.1002/cmdc.201000011. Review.

PMID:
20229564
4.

The Hedgehog signaling pathway as a target for anticancer drug discovery.

Borzillo GV, Lippa B.

Curr Top Med Chem. 2005;5(2):147-57. Review.

PMID:
15853643
5.

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Scales SJ, de Sauvage FJ.

Trends Pharmacol Sci. 2009 Jun;30(6):303-12. doi: 10.1016/j.tips.2009.03.007. Epub 2009 May 13. Review.

PMID:
19443052
6.

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.

Yun JI, Kim HR, Park H, Kim SK, Lee J.

Arch Pharm Res. 2012 Aug;35(8):1317-33. doi: 10.1007/s12272-012-0801-8. Epub 2012 Sep 1. Review.

PMID:
22941475
7.

Small-molecule modulators of Hh and Wnt signaling pathways.

Kiselyov AS, Tkachenko SE, Balakin KV, Ivachtchenko AV.

Expert Opin Ther Targets. 2007 Aug;11(8):1087-101. Review.

PMID:
17665980
8.

The hedgehog pathway as a therapeutic target for treatment of breast cancer.

Barginear MF, Leung M, Budman DR.

Breast Cancer Res Treat. 2009 Jul;116(2):239-46. doi: 10.1007/s10549-009-0423-0. Epub 2009 May 29. Review.

PMID:
19479372
9.

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

Büttner A, Seifert K, Cottin T, Sarli V, Tzagkaroulaki L, Scholz S, Giannis A.

Bioorg Med Chem. 2009 Jul 15;17(14):4943-54. doi: 10.1016/j.bmc.2009.06.008. Epub 2009 Jun 10.

PMID:
19541490
10.

Advances in targeting the Hedgehog signaling pathway in cancer therapy.

Kiesslich T, Neureiter D.

Expert Opin Ther Targets. 2012 Feb;16(2):151-6. doi: 10.1517/14728222.2012.652948. Epub 2012 Jan 11.

PMID:
22233124
11.

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription.

Hosoya T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

Chembiochem. 2008 May 5;9(7):1082-92. doi: 10.1002/cbic.200700511.

PMID:
18357592
12.

Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer.

Nehmé R, Mus-Veteau I.

Expert Rev Proteomics. 2010 Aug;7(4):601-12. doi: 10.1586/epr.10.39. Review.

PMID:
20653513
13.

Activation of Hedgehog pathway in gastrointestinal cancers.

Yang L, Su X, Xie J.

Vitam Horm. 2012;88:461-72. doi: 10.1016/B978-0-12-394622-5.00020-1. Review.

PMID:
22391316
14.

Medicinal chemistry inspired fragment-based drug discovery.

Lanter J, Zhang X, Sui Z.

Methods Enzymol. 2011;493:421-45. doi: 10.1016/B978-0-12-381274-2.00016-9.

PMID:
21371600
15.

Recent progress in the discovery and development of negative allosteric modulators of mGluR5.

Lindsley CW, Emmitte KA.

Curr Opin Drug Discov Devel. 2009 Jul;12(4):446-57. Review.

PMID:
19562641
16.

Hedgehog signaling pathway: development of antagonists for cancer therapy.

Xie J.

Curr Oncol Rep. 2008 Mar;10(2):107-13. Review.

PMID:
18377823
17.

Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.

Banerjee U, Hadden MK.

Expert Opin Drug Discov. 2014 Jul;9(7):751-71. doi: 10.1517/17460441.2014.920817. Epub 2014 May 22. Review.

PMID:
24850423
18.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

19.

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.

Yang L, Xie G, Fan Q, Xie J.

Oncogene. 2010 Jan 28;29(4):469-81. doi: 10.1038/onc.2009.392. Epub 2009 Nov 23. Review.

PMID:
19935712
20.

[New therapeutic strategy for cancer targeting the hedgehog signaling pathway].

Nakamura M, Kubo M, Nagai S, Yamaguchi K, Tanaka M, Katano M.

Gan To Kagaku Ryoho. 2007 Nov;34(12):1914-6. Japanese.

PMID:
18219851
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