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Results: 1 to 20 of 117

1.

Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms.

Cepeda C, Cummings DM, André VM, Holley SM, Levine MS.

ASN Neuro. 2010 Apr 7;2(2):e00033. doi: 10.1042/AN20090058. Review.

PMID:
20396376
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease.

Cummings DM, Cepeda C, Levine MS.

ASN Neuro. 2010 Jun 18;2(3):e00036. doi: 10.1042/AN20100007.

PMID:
20585470
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease.

Starling AJ, André VM, Cepeda C, de Lima M, Chandler SH, Levine MS.

J Neurosci Res. 2005 Nov 1;82(3):377-86.

PMID:
16211559
[PubMed - indexed for MEDLINE]
4.

Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.

Fan J, Cowan CM, Zhang LY, Hayden MR, Raymond LA.

J Neurosci. 2009 Sep 2;29(35):10928-38. doi: 10.1523/JNEUROSCI.2491-09.2009.

PMID:
19726651
[PubMed - indexed for MEDLINE]
Free Article
5.

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.

Neurobiol Dis. 2008 Jul;31(1):80-8. doi: 10.1016/j.nbd.2008.03.010. Epub 2008 Apr 16.

PMID:
18502655
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.

Milnerwood AJ, Raymond LA.

J Physiol. 2007 Dec 15;585(Pt 3):817-31. Epub 2007 Oct 18.

PMID:
17947312
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

PMID:
10434303
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

Heikkinen T, Lehtimäki K, Vartiainen N, Puoliväli J, Hendricks SJ, Glaser JR, Bradaia A, Wadel K, Touller C, Kontkanen O, Yrjänheikki JM, Buisson B, Howland D, Beaumont V, Munoz-Sanjuan I, Park LC.

PLoS One. 2012;7(12):e50717. doi: 10.1371/journal.pone.0050717. Epub 2012 Dec 20.

PMID:
23284644
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

Cell Death Differ. 2004 Apr;11(4):424-38.

PMID:
14713958
[PubMed - indexed for MEDLINE]
Free Article
10.

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, Phillips AG, Rubin EM, Hersch SM, Hayden MR.

Neuron. 1999 May;23(1):181-92.

PMID:
10402204
[PubMed - indexed for MEDLINE]
Free Article
11.

Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.

Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR.

J Neurosci. 2007 Oct 24;27(43):11758-68.

PMID:
17959817
[PubMed - indexed for MEDLINE]
Free Article
12.

Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse.

Brown TB, Bogush AI, Ehrlich ME.

Hum Mol Genet. 2008 Oct 15;17(20):3095-104. doi: 10.1093/hmg/ddn206. Epub 2008 Jul 16.

PMID:
18632688
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease.

Nithianantharajah J, Hannan AJ.

Neuroscience. 2013 Oct 22;251:66-74. doi: 10.1016/j.neuroscience.2012.05.043. Epub 2012 May 24. Review.

PMID:
22633949
[PubMed - indexed for MEDLINE]
14.

Reduced striatal acetylcholine efflux in the R6/2 mouse model of Huntington's disease: an examination of the role of altered inhibitory and excitatory mechanisms.

Farrar AM, Callahan JW, Abercrombie ED.

Exp Neurol. 2011 Dec;232(2):119-25. doi: 10.1016/j.expneurol.2011.08.010. Epub 2011 Aug 16.

PMID:
21864528
[PubMed - indexed for MEDLINE]
15.

Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease.

Cummings DM, André VM, Uzgil BO, Gee SM, Fisher YE, Cepeda C, Levine MS.

J Neurosci. 2009 Aug 19;29(33):10371-86. doi: 10.1523/JNEUROSCI.1592-09.2009.

PMID:
19692612
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martín-Ibañez R, Muñoz MT, Mengod G, Ernfors P, Alberch J.

J Neurosci. 2004 Sep 1;24(35):7727-39.

PMID:
15342740
[PubMed - indexed for MEDLINE]
Free Article
17.

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.

Fan MM, Fernandes HB, Zhang LY, Hayden MR, Raymond LA.

J Neurosci. 2007 Apr 4;27(14):3768-79.

PMID:
17409241
[PubMed - indexed for MEDLINE]
Free Article
18.

Transgenic mouse models of Parkinson's disease and Huntington's disease.

Skaper SD, Giusti P.

CNS Neurol Disord Drug Targets. 2010 Aug;9(4):455-70. Review.

PMID:
20522011
[PubMed - indexed for MEDLINE]
19.

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

Raymond LA, André VM, Cepeda C, Gladding CM, Milnerwood AJ, Levine MS.

Neuroscience. 2011 Dec 15;198:252-73. doi: 10.1016/j.neuroscience.2011.08.052. Epub 2011 Aug 27. Review.

PMID:
21907762
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.

Gharami K, Xie Y, An JJ, Tonegawa S, Xu B.

J Neurochem. 2008 Apr;105(2):369-79. Epub 2007 Dec 12.

PMID:
18086127
[PubMed - indexed for MEDLINE]
Free PMC Article

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