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Items: 1 to 20 of 306


Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.

Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R.

PLoS Genet. 2010 Apr 8;6(4):e1000901. doi: 10.1371/journal.pgen.1000901.


Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.

Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF.

Dev Biol. 2001 Aug 15;236(2):421-35.


Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud.

Hayes C, Brown JM, Lyon MF, Morriss-Kay GM.

Development. 1998 Feb;125(3):351-7.


Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

te Welscher P, Zuniga A, Kuijper S, Drenth T, Goedemans HJ, Meijlink F, Zeller R.

Science. 2002 Oct 25;298(5594):827-30. Epub 2002 Sep 5.


A dual role for Hox genes in limb anterior-posterior asymmetry.

Zákány J, Kmita M, Duboule D.

Science. 2004 Jun 11;304(5677):1669-72.


GATA6 is a crucial regulator of Shh in the limb bud.

Kozhemyakina E, Ionescu A, Lassar AB.

PLoS Genet. 2014 Jan;10(1):e1004072. doi: 10.1371/journal.pgen.1004072. Epub 2014 Jan 9.


Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.

Itou J, Kawakami H, Quach T, Osterwalder M, Evans SM, Zeller R, Kawakami Y.

Development. 2012 May;139(9):1620-9. doi: 10.1242/dev.073056. Epub 2012 Mar 21.


Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.

Akiyama H, Stadler HS, Martin JF, Ishii TM, Beachy PA, Nakamura T, de Crombrugghe B.

Matrix Biol. 2007 May;26(4):224-33. Epub 2006 Dec 8.


Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb.

Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen YT, Behringer RR, Sun X.

Development. 2010 Oct;137(20):3417-26. doi: 10.1242/dev.051789. Epub 2010 Sep 8.


HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R.

Dev Cell. 2014 Nov 10;31(3):345-57. doi: 10.1016/j.devcel.2014.09.018. Epub 2014 Nov 10.


Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.

Quinn ME, Haaning A, Ware SM.

Hum Mol Genet. 2012 Apr 15;21(8):1888-96. doi: 10.1093/hmg/dds002. Epub 2012 Jan 10.


Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds.

Zuniga A, Laurent F, Lopez-Rios J, Klasen C, Matt N, Zeller R.

BMC Dev Biol. 2012 Aug 13;12:23. doi: 10.1186/1471-213X-12-23.


Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.

Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X.

Development. 2005 Oct;132(19):4235-45. Epub 2005 Aug 24.


A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.

Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC.

Dev Cell. 2014 Apr 28;29(2):241-9. doi: 10.1016/j.devcel.2014.03.002. Epub 2014 Apr 10.


Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP.

Cell. 2001 Jun 1;105(5):599-612.


Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.

Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L.

Development. 2006 Jun;133(11):2263-73. Epub 2006 May 3.

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