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Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).

Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, Wong KW, Herman IM, Isberg RR, Buchsbaum RJ.

J Biol Chem. 2010 Jun 4;285(23):18060-71. doi: 10.1074/jbc.M109.051490. Epub 2010 Apr 1.


Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation.

Connolly BA, Rice J, Feig LA, Buchsbaum RJ.

Mol Cell Biol. 2005 Jun;25(11):4602-14. Erratum in: Mol Cell Biol. 2005 Sep;25(17):7928.


Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.

Van Leeuwen FN, Olivo C, Grivell S, Giepmans BN, Collard JG, Moolenaar WH.

J Biol Chem. 2003 Jan 3;278(1):400-6. Epub 2002 Oct 21.


IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.

Funato Y, Terabayashi T, Suenaga N, Seiki M, Takenawa T, Miki H.

Cancer Res. 2004 Aug 1;64(15):5237-44.


Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.

Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ.

Nat Cell Biol. 2002 Aug;4(8):621-5.


Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

Ten Klooster JP, Evers EE, Janssen L, Machesky LM, Michiels F, Hordijk P, Collard JG.

Biochem J. 2006 Jul 1;397(1):39-45.


The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.

Malliri A, van Es S, Huveneers S, Collard JG.

J Biol Chem. 2004 Jul 16;279(29):30092-8. Epub 2004 May 11.


The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration.

Hamelers IH, Olivo C, Mertens AE, Pegtel DM, van der Kammen RA, Sonnenberg A, Collard JG.

J Cell Biol. 2005 Dec 5;171(5):871-81.


Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression.

Engers R, Springer E, Michiels F, Collard JG, Gabbert HE.

J Biol Chem. 2001 Nov 9;276(45):41889-97. Epub 2001 Sep 10.


IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

Miki H, Yamaguchi H, Suetsugu S, Takenawa T.

Nature. 2000 Dec 7;408(6813):732-5.


Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.

Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F, Collard JG.

J Cell Biol. 1998 Nov 30;143(5):1385-98.


The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

Leeuwen FN, Kain HE, Kammen RA, Michiels F, Kranenburg OW, Collard JG.

J Cell Biol. 1997 Nov 3;139(3):797-807.


Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior.

Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG.

J Cell Biol. 1999 Nov 29;147(5):1009-22.


Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis.

Qi H, Juo P, Masuda-Robens J, Caloca MJ, Zhou H, Stone N, Kazanietz MG, Chou MM.

Cell Growth Differ. 2001 Dec;12(12):603-11.


The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.

Minard ME, Kim LS, Price JE, Gallick GE.

Breast Cancer Res Treat. 2004 Mar;84(1):21-32. Review.


Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.

Adams HC 3rd, Chen R, Liu Z, Whitehead IP.

Breast Cancer Res. 2010;12(5):R69. doi: 10.1186/bcr2637. Epub 2010 Sep 6.


Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ.

J Biol Chem. 2007 Dec 7;282(49):35666-78. Epub 2007 Oct 11.

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