Similar articles for PMID: 20337461

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1

Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.

Hamada M, Nakamura M, Kiuchi M, Marukawa K, Tomatsu A, Shimano K, Sato N, Sugahara K, Asayama M, Takagi K, Adachi K. Hamada M, et al. J Med Chem. 2010 Apr 22;53(8):3154-68. doi: 10.1021/jm901776q. J Med Chem. 2010. PMID: 20337461

2

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.

Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Clemens JJ, et al. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3568-72. doi: 10.1016/j.bmcl.2005.05.097. Bioorg Med Chem Lett. 2005. PMID: 15982878

3

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

Hale JJ, Neway W, Mills SG, Hajdu R, Ann Keohane C, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Koo GC, Koprak SL, Jackson JJ, Rosen H, Mandala S. Hale JJ, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3351-5. doi: 10.1016/j.bmcl.2004.02.106. Bioorg Med Chem Lett. 2004. PMID: 15149705

4

Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist.

Murakami A, Takasugi H, Ohnuma S, Koide Y, Sakurai A, Takeda S, Hasegawa T, Sasamori J, Konno T, Hayashi K, Watanabe Y, Mori K, Sato Y, Takahashi A, Mochizuki N, Takakura N. Murakami A, et al. Mol Pharmacol. 2010 Apr;77(4):704-13. doi: 10.1124/mol.109.061481. Epub 2010 Jan 22. Mol Pharmacol. 2010. PMID: 20097776

5

Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.

Yan L, Huo P, Doherty G, Toth L, Hale JJ, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Bergstrom J, Card D, Quackenbush E, Wickham A, Mandala SM. Yan L, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3679-83. doi: 10.1016/j.bmcl.2006.04.084. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16697189

6

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

Vachal P, Toth LM, Hale JJ, Yan L, Mills SG, Chrebet GL, Koehane CA, Hajdu R, Milligan JA, Rosenbach MJ, Mandala S. Vachal P, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3684-7. doi: 10.1016/j.bmcl.2006.04.064. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682185

7

Discovery of S1P agonists with a dihydronaphthalene scaffold.

Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Takada Y, Shioya H, Komiya T, Mizuno H, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3885-9. doi: 10.1016/j.bmcl.2011.05.029. Epub 2011 May 15. Bioorg Med Chem Lett. 2011. PMID: 21641216

8

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G, Hale J, Keohane C, Meyers C, Milligan J, Mills S, Nomura N, Rosen H, Rosenbach M, Shei GJ, Singer II, Tian M, West S, White V, Xie J, Proia RL, Mandala S. Forrest M, et al. J Pharmacol Exp Ther. 2004 May;309(2):758-68. doi: 10.1124/jpet.103.062828. Epub 2004 Jan 27. J Pharmacol Exp Ther. 2004. PMID: 14747617

9

The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.

Piali L, Froidevaux S, Hess P, Nayler O, Bolli MH, Schlosser E, Kohl C, Steiner B, Clozel M. Piali L, et al. J Pharmacol Exp Ther. 2011 May;337(2):547-56. doi: 10.1124/jpet.110.176487. Epub 2011 Feb 23. J Pharmacol Exp Ther. 2011. PMID: 21345969

10

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.

Hanessian S, Charron G, Billich A, Guerini D. Hanessian S, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):491-4. doi: 10.1016/j.bmcl.2006.10.014. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17070046

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