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Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies.

Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, Goldsby RA.

Infect Immun. 2010 Jun;78(6):2801-11. doi: 10.1128/IAI.01121-09. Epub 2010 Mar 22.


Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

Tilahun ME, Kwan A, Natarajan K, Quinn M, Tilahun AY, Xie C, Margulies DH, Osborne BA, Goldsby RA, Rajagopalan G.

PLoS One. 2011;6(11):e27203. doi: 10.1371/journal.pone.0027203. Epub 2011 Nov 15.


Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies.

Dutta K, Varshney AK, Franklin MC, Goger M, Wang X, Fries BC.

J Biol Chem. 2015 Mar 13;290(11):6715-30. doi: 10.1074/jbc.M114.630715. Epub 2015 Jan 8.


Murine monoclonal antibodies against staphylococcal enterotoxin B: production and characterization.

Goyache J, Orden JA, Blanco JL, Hernández J, Doménech A, Suárez G, Gómez-Lucía E.

FEMS Microbiol Immunol. 1992 Jul;4(5):247-54.


Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B.

Hamad AR, Herman A, Marrack P, Kappler JW.

J Exp Med. 1994 Aug 1;180(2):615-21.


Production and characterisation of monoclonal antibodies specific for staphylococcal enterotoxin B.

Lin YS, Largen MT, Newcomb JR, Rogers TJ.

J Med Microbiol. 1988 Dec;27(4):263-70.


Synthetic human monoclonal antibodies toward staphylococcal enterotoxin B (SEB) protective against toxic shock syndrome.

Karauzum H, Chen G, Abaandou L, Mahmoudieh M, Boroun AR, Shulenin S, Devi VS, Stavale E, Warfield KL, Zeitlin L, Roy CJ, Sidhu SS, Aman MJ.

J Biol Chem. 2012 Jul 20;287(30):25203-15. doi: 10.1074/jbc.M112.364075. Epub 2012 May 29.


Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice.

Varshney AK, Wang X, Aguilar JL, Scharff MD, Fries BC.

MBio. 2014 Jun 10;5(3):e01007-14. doi: 10.1128/mBio.01007-14.


Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock.

Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC.

J Biol Chem. 2011 Mar 18;286(11):9737-47. doi: 10.1074/jbc.M110.212407. Epub 2011 Jan 13. Erratum in: J Biol Chem. 2014 May 16;289(20):13706.


A co-stimulatory role for CD28 in the activation of CD4+ T lymphocytes by staphylococcal enterotoxin B.

Goldbach-Mansky R, King PD, Taylor AP, Dupont B.

Int Immunol. 1992 Dec;4(12):1351-60.


Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B.

Larkin EA, Stiles BG, Ulrich RG.

PLoS One. 2010 Oct 11;5(10):e13253. doi: 10.1371/journal.pone.0013253.


In vivo staphylococcal superantigen-driven polyclonal Ig responses in mice: dependence upon CD4(+) cells and human MHC class II.

Stohl W, Xu D, Zang S, Kim KS, Li L, Hanson JA, Stohlman SA, David CS, Jacob CO.

Int Immunol. 2001 Oct;13(10):1291-300.


Characterization of neutralizing mouse-human chimeric and shuffling antibodies against botulinum neurotoxin A.

Mukamoto M, Maeda H, Kohda T, Nozaki C, Takahashi M, Kozaki S.

Microbiol Immunol. 2012 Nov;56(11):748-55. doi: 10.1111/j.1348-0421.2012.00503.x.


Superantigen and endotoxin synergize in the induction of lethal shock.

Blank C, Luz A, Bendigs S, Erdmann A, Wagner H, Heeg K.

Eur J Immunol. 1997 Apr;27(4):825-33.


Structural basis for the neutralization and specificity of Staphylococcal enterotoxin B against its MHC Class II binding site.

Xia T, Liang S, Wang H, Hu S, Sun Y, Yu X, Han J, Li J, Guo S, Dai J, Lou Z, Guo Y.

MAbs. 2014 Jan-Feb;6(1):119-29. doi: 10.4161/mabs.27106.


Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia.

Gu L, Yue J, Zheng Y, Zheng X, Wang J, Wang Y, Li J, Jiang Y, Jiang H.

PLoS One. 2013;8(2):e55892. doi: 10.1371/journal.pone.0055892. Epub 2013 Feb 6.

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