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Results: 1 to 20 of 125

Similar articles for PubMed (Select 20303930)

1.

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.

Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H.

Chem Biol Interact. 2010 Sep 6;187(1-3):362-9. doi: 10.1016/j.cbi.2010.02.039. Epub 2010 Mar 19.

2.

Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity.

Amitai G, Adani R, Yacov G, Yishay S, Teitlboim S, Tveria L, Limanovich O, Kushnir M, Meshulam H.

Toxicology. 2007 Apr 20;233(1-3):187-98. Epub 2006 Oct 13.

PMID:
17129656
3.

Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.

Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS.

Chem Biol. 2012 Apr 20;19(4):456-66. doi: 10.1016/j.chembiol.2012.01.017.

4.

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.

Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS.

Nat Chem Biol. 2011 Feb;7(2):120-5. doi: 10.1038/nchembio.510. Epub 2011 Jan 9.

PMID:
21217689
5.

Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.

BriseƱo-Roa L, Hill J, Notman S, Sellers D, Smith AP, Timperley CM, Wetherell J, Williams NH, Williams GR, Fersht AR, Griffiths AD.

J Med Chem. 2006 Jan 12;49(1):246-55.

PMID:
16392809
6.

Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.

Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F.

Biochemistry. 2008 May 6;47(18):5216-24. doi: 10.1021/bi702222x. Epub 2008 Apr 9.

PMID:
18396898
7.

Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase.

Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H.

FEBS J. 2006 May;273(9):1906-19.

PMID:
16640555
8.

Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.

Tsai PC, Fox N, Bigley AN, Harvey SP, Barondeau DP, Raushel FM.

Biochemistry. 2012 Aug 14;51(32):6463-75. Epub 2012 Jul 31.

9.

Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.

Kirby SD, Norris JR, Richard Smith J, Bahnson BJ, Cerasoli DM.

Chem Biol Interact. 2013 Mar 25;203(1):181-5. doi: 10.1016/j.cbi.2012.10.023. Epub 2012 Nov 15.

PMID:
23159884
10.

Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity.

Amitai G, Adani R, Limanovich O, Teitlboim S, Yishay S, Tveria L, Yacov G, Meshulam H, Raveh L.

Chem Biol Interact. 2008 Sep 25;175(1-3):249-54. doi: 10.1016/j.cbi.2008.05.036. Epub 2008 Jun 6.

PMID:
18588863
11.

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.

Worek F, Seeger T, Goldsmith M, Ashani Y, Leader H, Sussman JS, Tawfik D, Thiermann H, Wille T.

Arch Toxicol. 2014 Jun;88(6):1257-66. doi: 10.1007/s00204-014-1204-z. Epub 2014 Jan 30.

PMID:
24477626
12.

In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity.

diTargiani RC, Chandrasekaran L, Belinskaya T, Saxena A.

Chem Biol Interact. 2010 Sep 6;187(1-3):349-54. doi: 10.1016/j.cbi.2010.02.021. Epub 2010 Feb 20.

PMID:
20176006
13.

Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1.

Valiyaveettil M, Alamneh Y, Biggemann L, Soojhawon I, Doctor BP, Nambiar MP.

Biochem Biophys Res Commun. 2010 Dec 3;403(1):97-102. doi: 10.1016/j.bbrc.2010.10.125. Epub 2010 Oct 30.

PMID:
21040699
14.

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.

Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS.

Toxicol Lett. 2011 Sep 25;206(1):24-8. doi: 10.1016/j.toxlet.2011.07.017. Epub 2011 Jul 23.

15.

Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase.

Yeung DT, Smith JR, Sweeney RE, Lenz DE, Cerasoli DM.

FEBS J. 2007 Mar;274(5):1183-91. Epub 2007 Feb 5.

PMID:
17286579
16.

Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.

Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J.

Chem Res Toxicol. 2009 Oct;22(10):1669-79. doi: 10.1021/tx900096j.

17.

Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.

Li WS, Lum KT, Chen-Goodspeed M, Sogorb MA, Raushel FM.

Bioorg Med Chem. 2001 Aug;9(8):2083-91.

PMID:
11504644
18.

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F.

Toxicol Lett. 2011 Sep 25;206(1):14-23. doi: 10.1016/j.toxlet.2011.05.1041. Epub 2011 Jun 12.

PMID:
21683774
19.

Progress in the development of enzyme-based nerve agent bioscavengers.

Nachon F, Brazzolotto X, Trovaslet M, Masson P.

Chem Biol Interact. 2013 Dec 5;206(3):536-44. doi: 10.1016/j.cbi.2013.06.012. Epub 2013 Jun 26. Review.

PMID:
23811386
20.

Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs.

Valiyaveettil M, Alamneh Y, Rezk P, Perkins MW, Sciuto AM, Doctor BP, Nambiar MP.

Toxicol Lett. 2011 May 10;202(3):203-8. doi: 10.1016/j.toxlet.2011.02.007. Epub 2011 Feb 15.

PMID:
21329748
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