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Results: 1 to 20 of 105

1.

Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.

Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P.

Bioorg Med Chem. 2010 Apr 1;18(7):2566-74. doi: 10.1016/j.bmc.2010.02.034. Epub 2010 Mar 1.

PMID:
20303767
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.

Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK.

Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. doi: 10.1016/j.bmcl.2008.03.083. Epub 2008 Apr 8.

PMID:
18420405
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.

Yang PY, Wang M, Li L, Wu H, He CY, Yao SQ.

Chemistry. 2012 May 21;18(21):6528-41. doi: 10.1002/chem.201103322. Epub 2012 Apr 4.

PMID:
22488888
[PubMed - indexed for MEDLINE]
4.

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.

Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE.

Mol Med. 2000 Aug;6(8):660-9.

PMID:
11055585
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.

Caffrey CR, Schanz M, Nkemngu NJ, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D.

Int J Antimicrob Agents. 2002 Mar;19(3):227-31. Erratum in: Int J Antimicrob Agents. 2005 Jul;26(1):100. Nkemgu-Njinkeng, Joseph [corrected to Nkemngu, Njinkeng Joseph]. Int J Antimicrob Agents. 2005 Nov;26(5):424.

PMID:
11932146
[PubMed - indexed for MEDLINE]
6.

Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness.

Navarro G, Chokpaiboon S, De Muylder G, Bray WM, Nisam SC, McKerrow JH, Pudhom K, Linington RG.

PLoS One. 2012;7(9):e46172. doi: 10.1371/journal.pone.0046172. Epub 2012 Sep 27.

PMID:
23029428
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.

Ettari R, Tamborini L, Angelo IC, Micale N, Pinto A, De Micheli C, Conti P.

J Med Chem. 2013 Jul 25;56(14):5637-58. doi: 10.1021/jm301424d. Epub 2013 May 7.

PMID:
23611656
[PubMed - indexed for MEDLINE]
8.

Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity.

Fytas C, Zoidis G, Tzoutzas N, Taylor MC, Fytas G, Kelly JM.

J Med Chem. 2011 Jul 28;54(14):5250-4. doi: 10.1021/jm200217m. Epub 2011 Jun 27.

PMID:
21542562
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Improved trypanocidal activities of cathepsin L inhibitors.

Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D.

Int J Antimicrob Agents. 2003 Aug;22(2):155-9.

PMID:
12927956
[PubMed - indexed for MEDLINE]
10.

2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7.

Wang Y, Li ZL, Bai J, Zhang LM, Wu X, Zhang L, Pei YH, Jing YK, Hua HM.

Chem Biodivers. 2012 Feb;9(2):385-93. doi: 10.1002/cbdv.201100061.

PMID:
22344914
[PubMed - indexed for MEDLINE]
11.

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB.

Eur J Med Chem. 2013 Aug;66:450-65. doi: 10.1016/j.ejmech.2013.05.007. Epub 2013 May 16.

PMID:
23831695
[PubMed - indexed for MEDLINE]
12.

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

Sykes ML, Baell JB, Kaiser M, Chatelain E, Moawad SR, Ganame D, Ioset JR, Avery VM.

PLoS Negl Trop Dis. 2012;6(11):e1896. doi: 10.1371/journal.pntd.0001896. Epub 2012 Nov 29.

PMID:
23209849
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Structure-guided development of selective TbcatB inhibitors.

Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK.

J Med Chem. 2009 Oct 22;52(20):6489-93. doi: 10.1021/jm900908p.

PMID:
19769357
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.

Usuki T, Sato M, Hara S, Yoshimoto Y, Kondo R, Zimmermann S, Kaiser M, Brun R, Hamburger M, Adams M.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):794-8. doi: 10.1016/j.bmcl.2013.12.099. Epub 2014 Jan 2.

PMID:
24433861
[PubMed - indexed for MEDLINE]
15.

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei.

Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH.

Exp Parasitol. 1999 Apr;91(4):349-55.

PMID:
10092479
[PubMed - indexed for MEDLINE]
16.

Trypanocidal activity of marine natural products.

Jones AJ, Grkovic T, Sykes ML, Avery VM.

Mar Drugs. 2013 Oct 22;11(10):4058-82. doi: 10.3390/md11104058. Review.

PMID:
24152565
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K.

J Med Chem. 2004 Jun 3;47(12):3212-9.

PMID:
15163200
[PubMed - indexed for MEDLINE]
18.

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ.

J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a.

PMID:
19908842
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK.

J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4.

PMID:
18173229
[PubMed - indexed for MEDLINE]
20.

Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets.

Ogungbe IV, Setzer WN.

Molecules. 2009 Apr 14;14(4):1513-36. doi: 10.3390/molecules14041513.

PMID:
19384282
[PubMed - indexed for MEDLINE]
Free Article

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