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Items: 1 to 20 of 123

1.

Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice.

Zhu H, Wang J, Wang P, Song W, Zheng Z, Chen R, Guo K, Zhang T, Peiris JS, Chen H, Guan Y.

Virology. 2010 May 25;401(1):1-5. doi: 10.1016/j.virol.2010.02.024. Epub 2010 Mar 19.

2.

Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.

Song MS, Pascua PN, Lee JH, Baek YH, Park KJ, Kwon HI, Park SJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2011 Jul;85(13):6275-86. doi: 10.1128/JVI.02125-10. Epub 2011 Apr 20.

3.

PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.

Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T.

J Virol. 2010 May;84(9):4395-406. doi: 10.1128/JVI.02642-09. Epub 2010 Feb 24.

4.

PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice.

Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE.

J Virol. 2011 Jan;85(1):357-65. doi: 10.1128/JVI.01694-10. Epub 2010 Oct 20.

5.

Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.

Mok CK, Lee HH, Lestra M, Nicholls JM, Chan MC, Sia SF, Zhu H, Poon LL, Guan Y, Peiris JS.

J Virol. 2014 Mar;88(6):3568-76. doi: 10.1128/JVI.02740-13. Epub 2014 Jan 8.

6.

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.

Zhu W, Zhu Y, Qin K, Yu Z, Gao R, Yu H, Zhou J, Shu Y.

PLoS One. 2012;7(3):e33383. doi: 10.1371/journal.pone.0033383. Epub 2012 Mar 15.

7.

Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models.

Ma W, Lager KM, Li X, Janke BH, Mosier DA, Painter LE, Ulery ES, Ma J, Lekcharoensuk P, Webby RJ, Richt JA.

Virology. 2011 Feb 5;410(1):1-6. doi: 10.1016/j.virol.2010.10.027. Epub 2010 Nov 11.

8.

Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus.

Zhou B, Pearce MB, Li Y, Wang J, Mason RJ, Tumpey TM, Wentworth DE.

PLoS One. 2013 Jun 14;8(6):e67616. doi: 10.1371/journal.pone.0067616. Print 2013.

9.

Effects of different polymerases of avian influenza viruses on the growth and pathogenicity of A/Puerto Rico/8/1934 (H1N1)-derived reassorted viruses.

Kim IH, Choi JG, Lee YJ, Kwon HJ, Kim JH.

Vet Microbiol. 2014 Jan 10;168(1):41-9. doi: 10.1016/j.vetmic.2013.10.011. Epub 2013 Oct 26.

PMID:
24296300
10.

Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission.

Herfst S, Chutinimitkul S, Ye J, de Wit E, Munster VJ, Schrauwen EJ, Bestebroer TM, Jonges M, Meijer A, Koopmans M, Rimmelzwaan GF, Osterhaus AD, Perez DR, Fouchier RA.

J Virol. 2010 Apr;84(8):3752-8. doi: 10.1128/JVI.02634-09. Epub 2010 Feb 3.

11.

Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus.

Zhang Y, Zhang Q, Gao Y, He X, Kong H, Jiang Y, Guan Y, Xia X, Shu Y, Kawaoka Y, Bu Z, Chen H.

J Virol. 2012 Sep;86(18):9666-74. doi: 10.1128/JVI.00958-12. Epub 2012 Jun 27.

12.

Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein.

Bogs J, Kalthoff D, Veits J, Pavlova S, Schwemmle M, Mänz B, Mettenleiter TC, Stech J.

J Virol. 2011 Oct;85(20):10691-8. doi: 10.1128/JVI.00786-11. Epub 2011 Aug 17.

13.

PB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression.

Zhao Z, Yi C, Zhao L, Wang S, Zhou L, Hu Y, Zou W, Chen H, Jin M.

J Virol. 2014 Feb;88(4):2260-7. doi: 10.1128/JVI.03024-13. Epub 2013 Dec 11.

14.

The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.

Long JS, Howard WA, Núñez A, Moncorgé O, Lycett S, Banks J, Barclay WS.

J Virol. 2013 Sep;87(18):9983-96. doi: 10.1128/JVI.01399-13. Epub 2013 Jul 10.

15.

A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice.

Yu Z, Cheng K, Sun W, Zhang X, Li Y, Wang T, Wang H, Zhang Q, Xin Y, Xue L, Zhang K, Huang J, Yang S, Qin C, Wilker PR, Yue D, Chen H, Gao Y, Xia X.

Virology. 2015 Dec;486:180-6. doi: 10.1016/j.virol.2015.09.014. Epub 2015 Oct 9.

PMID:
26453960
16.

Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.

Qi L, Davis AS, Jagger BW, Schwartzman LM, Dunham EJ, Kash JC, Taubenberger JK.

J Virol. 2012 Sep;86(17):9211-20. doi: 10.1128/JVI.00887-12. Epub 2012 Jun 20.

17.

[Establishment of a mouse-lethal model for pandemic H1N1 influenza virus].

Zhu Y, Liu LQ, Zhou JF, Zhu WF, Qin K, Yu ZJ, Wang DY, Zhao X, Li XY, Lan Y, Shu YL.

Bing Du Xue Bao. 2011 Mar;27(2):103-7. Chinese.

PMID:
21528533
18.

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.

Zheng B, Chan KH, Zhang AJ, Zhou J, Chan CC, Poon VK, Zhang K, Leung VH, Jin DY, Woo PC, Chan JF, To KK, Chen H, Yuen KY.

Exp Biol Med (Maywood). 2010 Aug;235(8):981-8. doi: 10.1258/ebm.2010.010071.

PMID:
20660098
19.

Polymerase complex with lysine at position 627 of the PB2 of influenza virus A/Hong Kong/483/97 (H5N1) efficiently transcribes and replicates virus genes in mouse cells.

Yamamoto N, Sakoda Y, Okamatsu M, Kida H.

Virus Res. 2013 Dec 26;178(2):404-10. doi: 10.1016/j.virusres.2013.09.012. Epub 2013 Sep 23.

PMID:
24070983
20.

Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses.

Ozawa M, Basnet S, Burley LM, Neumann G, Hatta M, Kawaoka Y.

J Virol. 2011 May;85(9):4596-601. doi: 10.1128/JVI.00029-11. Epub 2011 Feb 16.

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