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Results: 1 to 20 of 104

1.

Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.

Kuduk SD, Di Marco CN, Chang RK, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2533-7. doi: 10.1016/j.bmcl.2010.02.096. Epub 2010 Mar 3.

PMID:
20303264
[PubMed - indexed for MEDLINE]
2.

Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators.

Kuduk SD, DiPardo RM, Beshore DC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2538-41. doi: 10.1016/j.bmcl.2010.02.095. Epub 2010 Mar 10.

PMID:
20346667
[PubMed - indexed for MEDLINE]
3.

N-heterocyclic derived M1 positive allosteric modulators.

Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Veng L, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1334-7. doi: 10.1016/j.bmcl.2010.01.013. Epub 2010 Jan 11.

PMID:
20097564
[PubMed - indexed for MEDLINE]
4.

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.

Yang FV, Shipe WD, Bunda JL, Nolt MB, Wisnoski DD, Zhao Z, Barrow JC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Hartman GD, Lindsley CW.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):531-6. doi: 10.1016/j.bmcl.2009.11.100. Epub 2009 Nov 24.

PMID:
20004574
[PubMed - indexed for MEDLINE]
5.

Fused heterocyclic M1 positive allosteric modulators.

Kuduk SD, Di Marco CN, Cofre V, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2011 May 1;21(9):2769-72. doi: 10.1016/j.bmcl.2010.10.028. Epub 2010 Oct 16.

PMID:
21055928
[PubMed - indexed for MEDLINE]
6.

Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):657-61. doi: 10.1016/j.bmcl.2009.11.059. Epub 2009 Dec 2. Erratum in: Bioorg Med Chem Lett. 2010 Mar 1;20(5):1796. Seager, Matthew [corrected to Seager, Matthew A].

PMID:
19962304
[PubMed - indexed for MEDLINE]
7.

A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives.

Fernandez MC, Castaño A, Dominguez E, Escribano A, Jiang D, Jimenez A, Hong E, Hornback WJ, Nisenbaum ES, Rankl N, Tromiczak E, Vaught G, Zarrinmayeh H, Zimmerman DM.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5057-61. Epub 2006 Aug 1.

PMID:
16879964
[PubMed - indexed for MEDLINE]
8.

Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure.

Amr AG, Abdulla MM.

Bioorg Med Chem. 2006 Jul 1;14(13):4341-52. Epub 2006 Mar 20.

PMID:
16545570
[PubMed - indexed for MEDLINE]
9.

Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.

Mueller R, Rachwal S, Varney MA, Johnson SA, Alisala K, Zhong S, Li YX, Haroldsen P, Herbst T, Street LJ.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7455-9. doi: 10.1016/j.bmcl.2011.09.132. Epub 2011 Oct 8.

PMID:
22056742
[PubMed - indexed for MEDLINE]
11.

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.

Ritzén A, Sindet R, Hentzer M, Svendsen N, Brodbeck RM, Bundgaard C.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3275-8. doi: 10.1016/j.bmcl.2009.04.095. Epub 2009 Apr 24.

PMID:
19443216
[PubMed - indexed for MEDLINE]
12.

Recent development of cyclic amide (pyridone/lactam) moiety containing heterocycles as protein kinase inhibitors.

Wei L, Malhotra SV.

Curr Med Chem. 2010;17(3):234-53. Review.

PMID:
20214566
[PubMed - indexed for MEDLINE]
13.

Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.

Berg V, Das P, Chorell E, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3536-40. doi: 10.1016/j.bmcl.2008.05.020. Epub 2008 May 7.

PMID:
18499455
[PubMed - indexed for MEDLINE]
Free PMC Article
14.
15.

Investigation of the common mechanism of action of antibacterial compounds containing gamma-pyridone-beta-carboxylic acid structure by principal component.

Darvas F, Mészáros Z, Kovács L, Hermecz I, Balogh M, Kardos J.

Arzneimittelforschung. 1979;29(9):1334-9.

PMID:
583239
[PubMed - indexed for MEDLINE]
16.

Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Abeta-peptide aggregation inhibitors.

Aberg V, Norman F, Chorell E, Westermark A, Olofsson A, Sauer-Eriksson AE, Almqvist F.

Org Biomol Chem. 2005 Aug 7;3(15):2817-23. Epub 2005 Jun 29.

PMID:
16032359
[PubMed - indexed for MEDLINE]
17.

A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.

Zarrinmayeh H, Tromiczak E, Zimmerman DM, Rankl N, Ho KH, Dominguez E, Castaño A, Escribano A, Fernandez C, Jimenez A, Hornback WJ, Nisenbaum ES.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5203-6. Epub 2006 Jul 25.

PMID:
16872827
[PubMed - indexed for MEDLINE]
18.

Et3N-induced demethylation-annulation of 3-alkynyl-4-methoxy-2-pyridones and structurally related compounds in the synthesis of furan-fused heterocycles.

Conreaux D, Belot S, Desbordes P, Monteiro N, Balme G.

J Org Chem. 2008 Nov 7;73(21):8619-22. doi: 10.1021/jo8014038. Epub 2008 Oct 3.

PMID:
18831568
[PubMed - indexed for MEDLINE]
19.

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.

Tresadern G, Cid JM, Macdonald GJ, Vega JA, de Lucas AI, García A, Matesanz E, Linares ML, Oehlrich D, Lavreysen H, Biesmans I, Trabanco AA.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):175-9. doi: 10.1016/j.bmcl.2009.11.008. Epub 2009 Nov 10.

PMID:
19932615
[PubMed - indexed for MEDLINE]
20.

Effect of a proline analogue, azetidine-2-carboxylic acid, on the morphogenesis in vitro of mouse embryonic lung.

Alescio T.

J Embryol Exp Morphol. 1973 Apr;29(2):439-51. No abstract available.

PMID:
4717977
[PubMed - indexed for MEDLINE]
Free Article
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