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Items: 1 to 20 of 905

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Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.

Ulivi P, Arienti C, Amadori D, Fabbri F, Carloni S, Tesei A, Vannini I, Silvestrini R, Zoli W.

J Cell Physiol. 2009 Jul;220(1):214-21. doi: 10.1002/jcp.21753.

PMID:
19288493
3.

Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo.

Wei G, Wang M, Hyslop T, Wang Z, Carr BI.

Int J Cancer. 2010 Dec 15;127(12):2949-58. doi: 10.1002/ijc.25498.

4.

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway.

Showalter SL, Wang Z, Costantino CL, Witkiewicz AK, Yeo CJ, Brody JR, Carr BI.

J Gastroenterol Hepatol. 2010 Apr;25(4):738-44. doi: 10.1111/j.1440-1746.2009.06085.x. Epub 2009 Nov 19.

PMID:
19929921
5.

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C.

Cancer Res. 2006 Dec 15;66(24):11851-8.

6.

Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL.

Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou YS, Kuo WH.

Arch Toxicol. 2007 Oct;81(10):719-28. Epub 2007 Aug 3.

PMID:
17673978
7.

Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction.

Manov I, Pollak Y, Broneshter R, Iancu TC.

FEBS J. 2011 Sep;278(18):3494-507. doi: 10.1111/j.1742-4658.2011.08271.x.

8.

c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.

Carr BI, Wang Z, Wang M, Cavallini A, D'Alessandro R, Refolo MG.

Cancer Biol Ther. 2011 Sep 15;12(6):531-8. doi: 10.4161/cbt.12.6.16053. Epub 2011 Sep 15.

PMID:
21734462
9.

Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway.

Peng CL, Guo W, Ji T, Ren T, Yang Y, Li DS, Qu HY, Li X, Tang S, Yan TQ, Tang XD.

Cancer Biol Ther. 2009 Sep;8(18):1729-36. Epub 2009 Sep 6.

PMID:
19633425
10.

Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway.

Du W, Zhou JR, Wang DL, Gong K, Zhang QJ.

World J Surg Oncol. 2012 Apr 21;10:60. doi: 10.1186/1477-7819-10-60.

11.

Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway.

Lu X, Tang X, Guo W, Ren T, Zhao H.

J Surg Oncol. 2010 Dec 1;102(7):821-6. doi: 10.1002/jso.21661.

PMID:
20812347
12.

Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma.

Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, Wang DS, Lu YS, Hsu C, Cheng AL.

Clin Cancer Res. 2009 Sep 15;15(18):5820-8. doi: 10.1158/1078-0432.CCR-08-3294. Epub 2009 Sep 8.

13.

Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells.

Jia L, Yu W, Wang P, Li J, Sanders BG, Kline K.

Prostate. 2008 Mar 1;68(4):427-41. doi: 10.1002/pros.20716.

PMID:
18196534
14.

Suppression of ERK signaling evokes autocrine Fas-mediated death in arachidonic acid-treated human chronic myeloid leukemia K562 cells.

Chen KC, Liu WH, Chang LS.

J Cell Physiol. 2010 Mar;222(3):625-34. doi: 10.1002/jcp.21979.

PMID:
19927299
15.

Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways.

Yu C, Friday BB, Lai JP, Yang L, Sarkaria J, Kay NE, Carter CA, Roberts LR, Kaufmann SH, Adjei AA.

Mol Cancer Ther. 2006 Sep;5(9):2378-87.

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17.

Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.

Jang ER, Kim YJ, Myung SC, Kim W, Lee CS.

Mol Cell Biochem. 2011 Jul;353(1-2):1-11. doi: 10.1007/s11010-011-0768-7. Epub 2011 Mar 6.

PMID:
21380726
18.

The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms.

Llobet D, Eritja N, Yeramian A, Pallares J, Sorolla A, Domingo M, Santacana M, Gonzalez-Tallada FJ, Matias-Guiu X, Dolcet X.

Eur J Cancer. 2010 Mar;46(4):836-50. doi: 10.1016/j.ejca.2009.12.025. Epub 2010 Jan 12.

PMID:
20071162
19.

alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells.

Yu W, Shun MC, Anderson K, Chen H, Sanders BG, Kline K.

Apoptosis. 2006 Oct;11(10):1813-23.

PMID:
16850165
20.
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