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PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.

Faghiri Z, Bazan NG.

Exp Eye Res. 2010 Jun;90(6):718-25. doi: 10.1016/j.exer.2010.03.002. Epub 2010 Mar 15.


NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling.

Halapin NA, Bazan NG.

Neurochem Res. 2010 Dec;35(12):1944-7. doi: 10.1007/s11064-010-0351-8. Epub 2010 Dec 7.


The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: interaction with B-Raf/ERK.

Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):421-9. doi: 10.1167/iovs.09-3974. Epub 2009 Aug 6.


Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment epithelial cells.

Cao GF, Liu Y, Yang W, Wan J, Yao J, Wan Y, Jiang Q.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):499-505. doi: 10.1016/j.bbrc.2011.09.094. Epub 2011 Sep 24.


ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation.

Parrales A, López E, Lee-Rivera I, López-Colomé AM.

Cell Signal. 2013 Apr;25(4):829-38. doi: 10.1016/j.cellsig.2012.12.023. Epub 2013 Jan 3.


Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1.

Calandria JM, Mukherjee PK, de Rivero Vaccari JC, Zhu M, Petasis NA, Bazan NG.

J Biol Chem. 2012 Jul 6;287(28):23726-39. doi: 10.1074/jbc.M111.287078. Epub 2012 Apr 16.


L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways.

Ryu JM, Han HJ.

J Biol Chem. 2011 Jul 8;286(27):23667-78. doi: 10.1074/jbc.M110.216283. Epub 2011 May 6.


Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.

Li Z, Dong X, Liu H, Chen X, Shi H, Fan Y, Hou D, Zhang X.

Mol Vis. 2013 Jul 25;19:1656-66. Print 2013.


G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.

Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH.

Am J Physiol Cell Physiol. 2004 Aug;287(2):C281-91. Epub 2004 Mar 17.


Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils.

Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Winkler JW, Petasis NA, Serhan CN, Bazan NG.

Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):27-34. doi: 10.1016/j.plefa.2009.10.010.


Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival.

Antony R, Lukiw WJ, Bazan NG.

J Biol Chem. 2010 Jun 11;285(24):18301-8. doi: 10.1074/jbc.M109.095232. Epub 2010 Apr 2.


Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.

Zhang L, Wang H, Xu J, Zhu J, Ding K.

Toxicol Lett. 2014 Aug 4;228(3):248-59. doi: 10.1016/j.toxlet.2014.05.015. Epub 2014 May 27.


Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt.

Byeon SH, Lee SC, Choi SH, Lee HK, Lee JH, Chu YK, Kwon OW.

Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1190-7. doi: 10.1167/iovs.09-4144. Epub 2009 Oct 15.


The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medullary thyroid carcinoma cells.

Grozinsky-Glasberg S, Rubinfeld H, Nordenberg Y, Gorshtein A, Praiss M, Kendler E, Feinmesser R, Grossman AB, Shimon I.

Mol Cell Endocrinol. 2010 Feb 5;315(1-2):87-94. doi: 10.1016/j.mce.2009.09.027. Epub 2009 Oct 6.


Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.

Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K, Imoto M, Hattori N.

Autophagy. 2011 Feb;7(2):176-87. Epub 2011 Feb 1.


Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts.

Matheny RW Jr, Adamo ML.

Biochem Biophys Res Commun. 2009 Dec 11;390(2):252-7. doi: 10.1016/j.bbrc.2009.09.100. Epub 2009 Sep 30.


Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1.

Calandria JM, Marcheselli VL, Mukherjee PK, Uddin J, Winkler JW, Petasis NA, Bazan NG.

J Biol Chem. 2009 Jun 26;284(26):17877-82. doi: 10.1074/jbc.M109.003988. Epub 2009 Apr 29.

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