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Items: 1 to 20 of 108

1.

The synapse and cytolytic machinery of cytotoxic T cells.

Jenkins MR, Griffiths GM.

Curr Opin Immunol. 2010 Jun;22(3):308-13. doi: 10.1016/j.coi.2010.02.008. Epub 2010 Mar 11. Review.

2.

The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.

Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM.

Immunity. 2009 Oct 16;31(4):621-31. doi: 10.1016/j.immuni.2009.08.024.

3.

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.

Bertrand F, Müller S, Roh KH, Laurent C, Dupré L, Valitutti S.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6073-8. doi: 10.1073/pnas.1218640110. Epub 2013 Mar 27.

4.

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Krönke M, Simon MM, Utermöhlen O.

Nat Immunol. 2009 Jul;10(7):761-8. doi: 10.1038/ni.1757. Epub 2009 Jun 14.

PMID:
19525969
5.

Centrosome polarization delivers secretory granules to the immunological synapse.

Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM.

Nature. 2006 Sep 28;443(7110):462-5. Erratum in: Nature. 2006 Nov 9;444(7116):236.

PMID:
17006514
6.

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.

Stinchcombe JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM.

BMC Biol. 2011 Jun 28;9:45. doi: 10.1186/1741-7007-9-45.

7.

Natural killer cell cytotoxicity: how do they pull the trigger?

Topham NJ, Hewitt EW.

Immunology. 2009 Sep;128(1):7-15. doi: 10.1111/j.1365-2567.2009.03123.x. Review.

8.

Centrosome docking at the immunological synapse is controlled by Lck signaling.

Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.

J Cell Biol. 2011 Feb 21;192(4):663-74. doi: 10.1083/jcb.201008140.

9.

Hedgehog signaling controls T cell killing at the immunological synapse.

de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM.

Science. 2013 Dec 6;342(6163):1247-50. doi: 10.1126/science.1244689.

10.

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.

Ménasché G, Ménager MM, Lefebvre JM, Deutsch E, Athman R, Lambert N, Mahlaoui N, Court M, Garin J, Fischer A, de Saint Basile G.

Blood. 2008 Dec 15;112(13):5052-62. doi: 10.1182/blood-2008-02-141069. Epub 2008 Sep 23.

11.

CTLs contain and use intracellular stores of FasL distinct from cytolytic granules.

He JS, Ostergaard HL.

J Immunol. 2007 Aug 15;179(4):2339-48.

12.

Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes.

Ming M, Schirra C, Becherer U, Stevens DR, Rettig J.

PLoS One. 2015 Aug 21;10(8):e0135994. doi: 10.1371/journal.pone.0135994. eCollection 2015.

13.

Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation.

Lui-Roberts WW, Stinchcombe JC, Ritter AT, Akhmanova A, Karakesisoglou I, Griffiths GM.

Eur J Immunol. 2012 Aug;42(8):2132-41. doi: 10.1002/eji.201242525.

14.

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.

de Saint Basile G, Ménasché G, Fischer A.

Nat Rev Immunol. 2010 Aug;10(8):568-79. doi: 10.1038/nri2803. Epub 2010 Jul 16. Review.

PMID:
20634814
15.

Genetic defects affecting lymphocyte cytotoxicity.

Fischer A, Latour S, de Saint Basile G.

Curr Opin Immunol. 2007 Jun;19(3):348-53. Epub 2007 Apr 12. Review.

PMID:
17433652
16.

Cytotoxic immunological synapses.

Dustin ML, Long EO.

Immunol Rev. 2010 May;235(1):24-34. doi: 10.1111/j.0105-2896.2010.00904.x. Review.

17.

Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

Stinchcombe JC, Barral DC, Mules EH, Booth S, Hume AN, Machesky LM, Seabra MC, Griffiths GM.

J Cell Biol. 2001 Feb 19;152(4):825-34.

18.

Role of centrosome in regulating immune response.

Kumar A, Rajendran V, Sethumadhavan R, Purohit R.

Curr Drug Targets. 2014 May;15(5):558-63. Review.

PMID:
24655141
19.

SNARE protein expression and localization in human cytotoxic T lymphocytes.

Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.

Eur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915. Epub 2012 Jan 5.

20.

Perforin: structure, function, and role in human immunopathology.

Voskoboinik I, Dunstone MA, Baran K, Whisstock JC, Trapani JA.

Immunol Rev. 2010 May;235(1):35-54. doi: 10.1111/j.0105-2896.2010.00896.x. Review.

PMID:
20536554
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