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Items: 1 to 20 of 87


Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium.

Suryakumar G, Kasiganesan H, Balasubramanian S, Kuppuswamy D.

J Cardiovasc Pharmacol. 2010 Jun;55(6):567-73. doi: 10.1097/FJC.0b013e3181d9f5d4.


In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium.

Mani SK, Shiraishi H, Balasubramanian S, Yamane K, Chellaiah M, Cooper G, Banik N, Zile MR, Kuppuswamy D.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H314-26. doi: 10.1152/ajpheart.00085.2008. Epub 2008 May 16.


Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy.

Johnston RK, Balasubramanian S, Kasiganesan H, Baicu CF, Zile MR, Kuppuswamy D.

FASEB J. 2009 Aug;23(8):2759-71. doi: 10.1096/fj.08-127480. Epub 2009 Apr 13.


β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse.

Balasubramanian S, Quinones L, Kasiganesan H, Zhang Y, Pleasant DL, Sundararaj KP, Zile MR, Bradshaw AD, Kuppuswamy D.

PLoS One. 2012;7(9):e45076. doi: 10.1371/journal.pone.0045076. Epub 2012 Sep 12.


Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation.

Ren J, Avery J, Zhao H, Schneider JG, Ross FP, Muslin AJ.

J Mol Cell Cardiol. 2007 Feb;42(2):367-77. Epub 2006 Dec 20.


STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMX.

Willey CD, Palanisamy AP, Johnston RK, Mani SK, Shiraishi H, Tuxworth WJ, Zile MR, Balasubramanian S, Kuppuswamy D.

Int J Biol Sci. 2008 Jun 27;4(3):184-99.


Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium.

Harston RK, McKillop JC, Moschella PC, Van Laer A, Quinones LS, Baicu CF, Balasubramanian S, Zile MR, Kuppuswamy D.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1696-706. doi: 10.1152/ajpheart.00545.2010. Epub 2011 Feb 25.


Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src.

Willey CD, Balasubramanian S, Rodríguez Rosas MC, Ross RS, Kuppuswamy D.

J Mol Cell Cardiol. 2003 Jun;35(6):671-83.


RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.

Takefuji M, Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N.

J Exp Med. 2013 Apr 8;210(4):665-73. doi: 10.1084/jem.20122126. Epub 2013 Mar 25.


Temporal changes in integrin-mediated cardiomyocyte adhesion secondary to chronic cardiac volume overload in rats.

Stewart JA Jr, Gardner JD, Brower GL, Janicki JS.

Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H101-8. doi: 10.1152/ajpheart.00541.2013. Epub 2013 Oct 25.


Cleavage of the cytoplasmic domain of the integrin beta3 subunit during endothelial cell apoptosis.

Meredith J Jr, Mu Z, Saido T, Du X.

J Biol Chem. 1998 Jul 31;273(31):19525-31.


Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices.

Nagai T, Laser M, Baicu CF, Zile MR, Cooper G 4th, Kuppuswamy D.

Am J Cardiol. 1999 Jun 17;83(12A):38H-43H.


[Signal transductional mechanism of calpain involved in the regulation of rat hypertrophy myocardium mediated by overloaded pressure].

Yang YJ, Liu HM, Zhang X, Zhang JH.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jul;38(4):599-602, 648. Chinese.


Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases.

Balasubramanian S, Mani S, Shiraishi H, Johnston RK, Yamane K, Willey CD, Cooper G 4th, Tuxworth WJ, Kuppuswamy D.

J Mol Cell Cardiol. 2006 Oct;41(4):669-79. Epub 2006 Aug 22.


Calpain inhibition preserves myocardial structure and function following myocardial infarction.

Mani SK, Balasubramanian S, Zavadzkas JA, Jeffords LB, Rivers WT, Zile MR, Mukherjee R, Spinale FG, Kuppuswamy D.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1744-51. doi: 10.1152/ajpheart.00338.2009. Epub 2009 Sep 4.


Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.

Ma J, Wei M, Wang Q, Li J, Wang H, Liu W, Lacefield JC, Greer PA, Karmazyn M, Fan GC, Peng T.

J Biol Chem. 2012 Aug 10;287(33):27480-9. doi: 10.1074/jbc.M112.358929. Epub 2012 Jun 29.


RGD-containing peptides activate S6K1 through beta3 integrin in adult cardiac muscle cells.

Balasubramanian S, Kuppuswamy D.

J Biol Chem. 2003 Oct 24;278(43):42214-24. Epub 2003 Aug 9.


Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy.

Lu Z, Xu X, Fassett J, Kwak D, Liu X, Hu X, Wang H, Guo H, Xu D, Yan S, McFalls EO, Lu F, Bache RJ, Chen Y.

Hypertension. 2014 Jan;63(1):128-35. doi: 10.1161/HYPERTENSIONAHA.113.02313. Epub 2013 Oct 28.


Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, Rockman HA.

Circulation. 2002 Jan 1;105(1):85-92.


Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation.

Higashikuni Y, Tanaka K, Kato M, Nureki O, Hirata Y, Nagai R, Komuro I, Sata M.

J Am Heart Assoc. 2013 Nov 18;2(6):e000267. doi: 10.1161/JAHA.113.000267.

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