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Results: 1 to 20 of 121

1.

Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage.

Lopez H, Zhang L, George NM, Liu X, Pang X, Evans JJ, Targy NM, Luo X.

J Biol Chem. 2010 May 14;285(20):15016-26. doi: 10.1074/jbc.M109.086231. Epub 2010 Mar 11.

PMID:
20223826
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.

Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X.

Cell Death Differ. 2011 May;18(5):864-73. doi: 10.1038/cdd.2010.152. Epub 2010 Nov 26.

PMID:
21113147
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

Yamaguchi H, Wang HG.

J Biol Chem. 2002 Nov 1;277(44):41604-12. Epub 2002 Aug 26.

PMID:
12198137
[PubMed - indexed for MEDLINE]
Free Article
4.

Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL.

Kutuk O, Temel SG, Tolunay S, Basaga H.

Eur J Cancer. 2010 Sep;46(13):2494-505. doi: 10.1016/j.ejca.2010.06.011. Epub 2010 Jul 7.

PMID:
20619636
[PubMed - indexed for MEDLINE]
5.

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Nat Cell Biol. 2006 Dec;8(12):1348-58. Epub 2006 Nov 19.

PMID:
17115033
[PubMed - indexed for MEDLINE]
6.

The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression.

Hagenbuchner J, Ausserlechner MJ, Porto V, David R, Meister B, Bodner M, Villunger A, Geiger K, Obexer P.

J Biol Chem. 2010 Mar 5;285(10):6904-12. doi: 10.1074/jbc.M109.038331. Epub 2010 Jan 5.

PMID:
20051518
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis.

Eno CO, Zhao G, Olberding KE, Li C.

Biochem J. 2012 May 15;444(1):69-78. doi: 10.1042/BJ20112023.

PMID:
22380599
[PubMed - indexed for MEDLINE]
Free Article
8.

Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on celecoxib-induced apoptosis.

Rudner J, Elsaesser SJ, Müller AC, Belka C, Jendrossek V.

Biochem Pharmacol. 2010 Jan 1;79(1):10-20. doi: 10.1016/j.bcp.2009.07.021. Epub 2009 Aug 7.

PMID:
19665451
[PubMed - indexed for MEDLINE]
9.

The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.

Seo YW, Shin JN, Ko KH, Cha JH, Park JY, Lee BR, Yun CW, Kim YM, Seol DW, Kim DW, Yin XM, Kim TH.

J Biol Chem. 2003 Nov 28;278(48):48292-9. Epub 2003 Sep 18.

PMID:
14500711
[PubMed - indexed for MEDLINE]
Free Article
10.

Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis.

Han J, Goldstein LA, Gastman BR, Rabinowich H.

J Biol Chem. 2006 Apr 14;281(15):10153-63. Epub 2006 Feb 13.

PMID:
16478725
[PubMed - indexed for MEDLINE]
Free Article
11.
12.

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases.

Holinger EP, Chittenden T, Lutz RJ.

J Biol Chem. 1999 May 7;274(19):13298-304.

PMID:
10224090
[PubMed - indexed for MEDLINE]
Free Article
13.

Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis.

Rudner J, Elsaesser SJ, Jendrossek V, Huber SM.

Biochem Pharmacol. 2011 Jan 1;81(1):32-42. doi: 10.1016/j.bcp.2010.09.002. Epub 2010 Sep 15.

PMID:
20836993
[PubMed - indexed for MEDLINE]
14.

Induction of Bad-mediated apoptosis by Sindbis virus infection: involvement of pro-survival members of the Bcl-2 family.

Moriishi K, Koura M, Matsuura Y.

Virology. 2002 Jan 20;292(2):258-71.

PMID:
11878929
[PubMed - indexed for MEDLINE]
15.

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC.

Genes Dev. 2005 Jun 1;19(11):1294-305. Epub 2005 May 18.

PMID:
15901672
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons.

Wyttenbach A, Tolkovsky AM.

J Neurochem. 2006 Mar;96(5):1213-26.

PMID:
16478523
[PubMed - indexed for MEDLINE]
17.

Vesicular stomatitis virus induces apoptosis primarily through Bak rather than Bax by inactivating Mcl-1 and Bcl-XL.

Pearce AF, Lyles DS.

J Virol. 2009 Sep;83(18):9102-12. doi: 10.1128/JVI.00436-09. Epub 2009 Jul 8.

PMID:
19587033
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members.

Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J.

J Biol Chem. 2007 Nov 16;282(46):33888-95. Epub 2007 Sep 24.

PMID:
17893147
[PubMed - indexed for MEDLINE]
Free Article
19.

Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis.

Sung KF, Odinokova IV, Mareninova OA, Rakonczay Z Jr, Hegyi P, Pandol SJ, Gukovsky I, Gukovskaya AS.

Exp Cell Res. 2009 Jul 1;315(11):1975-89. doi: 10.1016/j.yexcr.2009.01.009. Epub 2009 Jan 24.

PMID:
19331832
[PubMed - indexed for MEDLINE]
20.

Functional linkage between NOXA and Bim in mitochondrial apoptotic events.

Han J, Goldstein LA, Hou W, Rabinowich H.

J Biol Chem. 2007 Jun 1;282(22):16223-31. Epub 2007 Mar 20.

PMID:
17374615
[PubMed - indexed for MEDLINE]
Free Article
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