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Results: 1 to 20 of 245

1.

Approaches to phase 1 clinical trial design focused on safety, efficiency, and selected patient populations: a report from the clinical trial design task force of the national cancer institute investigational drug steering committee.

Ivy SP, Siu LL, Garrett-Mayer E, Rubinstein L.

Clin Cancer Res. 2010 Mar 15;16(6):1726-36. doi: 10.1158/1078-0432.CCR-09-1961. Epub 2010 Mar 9.

PMID:
20215542
[PubMed - indexed for MEDLINE]
Free Article
2.

The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee.

Seymour L, Ivy SP, Sargent D, Spriggs D, Baker L, Rubinstein L, Ratain MJ, Le Blanc M, Stewart D, Crowley J, Groshen S, Humphrey JS, West P, Berry D.

Clin Cancer Res. 2010 Mar 15;16(6):1764-9. doi: 10.1158/1078-0432.CCR-09-3287. Epub 2010 Mar 9.

PMID:
20215557
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents.

Dancey JE, Dobbin KK, Groshen S, Jessup JM, Hruszkewycz AH, Koehler M, Parchment R, Ratain MJ, Shankar LK, Stadler WM, True LD, Gravell A, Grever MR; Biomarkers Task Force of the NCI Investigational Drug Steering Committee.

Clin Cancer Res. 2010 Mar 15;16(6):1745-55. doi: 10.1158/1078-0432.CCR-09-2167. Epub 2010 Mar 9.

PMID:
20215558
[PubMed - indexed for MEDLINE]
Free Article
4.

An overview of the optimal planning, design, and conduct of phase I studies of new therapeutics.

LoRusso PM, Boerner SA, Seymour L.

Clin Cancer Res. 2010 Mar 15;16(6):1710-8. doi: 10.1158/1078-0432.CCR-09-1993. Epub 2010 Mar 9. Review.

PMID:
20215546
[PubMed - indexed for MEDLINE]
Free Article
5.

The investigational drug steering committee.

Ratain MJ.

Clin Adv Hematol Oncol. 2007 Oct;5(10):779-80. No abstract available.

PMID:
17998895
[PubMed - indexed for MEDLINE]
6.

Methodologic guidelines for the design of high-dose chemotherapy regimens.

Margolin K, Synold T, Longmate J, Doroshow JH.

Biol Blood Marrow Transplant. 2001;7(8):414-32. Review.

PMID:
11569887
[PubMed - indexed for MEDLINE]
7.

Novel designs and end points for phase II clinical trials.

Adjei AA, Christian M, Ivy P.

Clin Cancer Res. 2009 Mar 15;15(6):1866-72. doi: 10.1158/1078-0432.CCR-08-2035. Epub 2009 Mar 10. Review.

PMID:
19276272
[PubMed - indexed for MEDLINE]
Free Article
8.

The Challenge of Developing New Therapies for Childhood Cancers.

Balis FM.

Oncologist. 1997;2(1):I-II.

PMID:
10388032
[PubMed - as supplied by publisher]
9.

Molecular prescreening to select patient population in early clinical trials.

Rodón J, Saura C, Dienstmann R, Vivancos A, Ramón y Cajal S, Baselga J, Tabernero J.

Nat Rev Clin Oncol. 2012 Apr 3;9(6):359-66. doi: 10.1038/nrclinonc.2012.48.

PMID:
22473105
[PubMed - indexed for MEDLINE]
10.

Accelerated titration designs for phase I clinical trials in oncology.

Simon R, Freidlin B, Rubinstein L, Arbuck SG, Collins J, Christian MC.

J Natl Cancer Inst. 1997 Aug 6;89(15):1138-47.

PMID:
9262252
[PubMed - indexed for MEDLINE]
Free Article
11.

Efaproxiral: GSJ 61, JP 4, KDD 86, RS 4, RSR 13.

[No authors listed]

Drugs R D. 2005;6(3):178-85. Review.

PMID:
15869322
[PubMed - indexed for MEDLINE]
12.

Making the investigational oncology pipeline more efficient and effective: are we headed in the right direction?

LoRusso PM, Anderson AB, Boerner SA, Averbuch SD.

Clin Cancer Res. 2010 Dec 15;16(24):5956-62. doi: 10.1158/1078-0432.CCR-10-1279. Review.

PMID:
21169248
[PubMed - indexed for MEDLINE]
Free Article
13.

Do we make optimal use of the potential of cancer prevention?

Greenwald P, Dunn BK.

Recent Results Cancer Res. 2009;181:3-17. Review.

PMID:
19213552
[PubMed - indexed for MEDLINE]
14.

Lessons learned from independent central review.

Ford R, Schwartz L, Dancey J, Dodd LE, Eisenhauer EA, Gwyther S, Rubinstein L, Sargent D, Shankar L, Therasse P, Verweij J.

Eur J Cancer. 2009 Jan;45(2):268-74. doi: 10.1016/j.ejca.2008.10.031.

PMID:
19101138
[PubMed - indexed for MEDLINE]
15.

Workshop on phase I study design. Ninth NCI/EORTC New Drug Development Symposium, Amsterdam, March 12, 1996.

Arbuck SG.

Ann Oncol. 1996 Aug;7(6):567-73. Review.

PMID:
8879369
[PubMed - indexed for MEDLINE]
Free Article
16.

Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations.

Lieberman R, Nelson WG, Sakr WA, Meyskens FL Jr, Klein EA, Wilding G, Partin AW, Lee JJ, Lippman SM.

Urology. 2001 Apr;57(4 Suppl 1):4-27.

PMID:
11295590
[PubMed - indexed for MEDLINE]
17.

Dose escalation methods in phase I cancer clinical trials.

Le Tourneau C, Lee JJ, Siu LL.

J Natl Cancer Inst. 2009 May 20;101(10):708-20. doi: 10.1093/jnci/djp079. Epub 2009 May 12. Review.

PMID:
19436029
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Phase 0 clinical trials in cancer drug development: from FDA guidance to clinical practice.

Kinders R, Parchment RE, Ji J, Kummar S, Murgo AJ, Gutierrez M, Collins J, Rubinstein L, Pickeral O, Steinberg SM, Yang S, Hollingshead M, Chen A, Helman L, Wiltrout R, Simpson M, Tomaszewski JE, Doroshow JH.

Mol Interv. 2007 Dec;7(6):325-34. doi: 10.1124/mi.7.6.9. Review.

PMID:
18199854
[PubMed - indexed for MEDLINE]
19.

Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke.

Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, Dillon W, Warach S, Broderick J, Tilley B, Sacks D; Technology Assessment Committee of the American Society of Interventional and Therapeutic Neuroradiology; Technology Assessment Committee of the Society of Interventional Radiology.

Stroke. 2003 Aug;34(8):e109-37. Epub 2003 Jul 17. Erratum in: Stroke. 2003 Nov;34(11):2774.

PMID:
12869717
[PubMed - indexed for MEDLINE]
Free Article
20.

INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201.

[No authors listed]

Drugs R D. 2007;8(3):176-87. Review.

PMID:
17472413
[PubMed - indexed for MEDLINE]

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