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Results: 1 to 20 of 113

1.

Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration.

Gendron TF, Josephs KA, Petrucelli L.

Neuropathol Appl Neurobiol. 2010 Apr;36(2):97-112. doi: 10.1111/j.1365-2990.2010.01060.x. Epub 2010 Feb 19. Review.

PMID:
20202122
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Rodent models of TDP-43 proteinopathy: investigating the mechanisms of TDP-43-mediated neurodegeneration.

Gendron TF, Petrucelli L.

J Mol Neurosci. 2011 Nov;45(3):486-99. doi: 10.1007/s12031-011-9610-7. Epub 2011 Aug 3. Review.

PMID:
21811811
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

Baloh RH.

FEBS J. 2011 Oct;278(19):3539-49. doi: 10.1111/j.1742-4658.2011.08256.x. Epub 2011 Aug 24. Review.

PMID:
21777387
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.

Warraich ST, Yang S, Nicholson GA, Blair IP.

Int J Biochem Cell Biol. 2010 Oct;42(10):1606-9. doi: 10.1016/j.biocel.2010.06.016. Epub 2010 Jun 25. Review.

PMID:
20601083
[PubMed - indexed for MEDLINE]
5.

TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis.

Kwong LK, Uryu K, Trojanowski JQ, Lee VM.

Neurosignals. 2008;16(1):41-51. Epub 2007 Dec 5. Review.

PMID:
18097159
[PubMed - indexed for MEDLINE]
6.

TDP-43 aggregation in neurodegeneration: are stress granules the key?

Dewey CM, Cenik B, Sephton CF, Johnson BA, Herz J, Yu G.

Brain Res. 2012 Jun 26;1462:16-25. doi: 10.1016/j.brainres.2012.02.032. Epub 2012 Feb 22. Review.

PMID:
22405725
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.

Miguel L, Frébourg T, Campion D, Lecourtois M.

Neurobiol Dis. 2011 Feb;41(2):398-406. doi: 10.1016/j.nbd.2010.10.007. Epub 2010 Oct 14.

PMID:
20951205
[PubMed - indexed for MEDLINE]
8.

TAR DNA-binding protein 43 in neurodegenerative disease.

Chen-Plotkin AS, Lee VM, Trojanowski JQ.

Nat Rev Neurol. 2010 Apr;6(4):211-20. doi: 10.1038/nrneurol.2010.18. Epub 2010 Mar 16. Review.

PMID:
20234357
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

[TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis].

Kierdaszuk B, Berdyński M, Zekanowski C, Kamińska A.

Neurol Neurochir Pol. 2012 Jul-Aug;46(4):384-91. Review. Polish.

PMID:
23023438
[PubMed - indexed for MEDLINE]
10.

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders.

Janssens J, Van Broeckhoven C.

Hum Mol Genet. 2013 Oct 15;22(R1):R77-87. doi: 10.1093/hmg/ddt349. Epub 2013 Jul 29. Review.

PMID:
23900071
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.

Mackenzie IR, Rademakers R.

Curr Opin Neurol. 2008 Dec;21(6):693-700. doi: 10.1097/WCO.0b013e3283168d1d. Review.

PMID:
18989115
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

TDP-43 in aging and Alzheimer's disease - a review.

Wilson AC, Dugger BN, Dickson DW, Wang DS.

Int J Clin Exp Pathol. 2011 Jan 30;4(2):147-55. Review.

PMID:
21326809
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.

Medina DX, Orr ME, Oddo S.

Neurobiol Aging. 2014 Jan;35(1):79-87. doi: 10.1016/j.neurobiolaging.2013.07.006. Epub 2013 Aug 15.

PMID:
23954172
[PubMed - indexed for MEDLINE]
14.

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.

Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, Julien JP.

Brain. 2011 Sep;134(Pt 9):2610-26. doi: 10.1093/brain/awr159. Epub 2011 Jul 13.

PMID:
21752789
[PubMed - indexed for MEDLINE]
Free Article
15.

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, Lewis J, Petrucelli L.

Mol Neurodegener. 2011 Oct 26;6:73. doi: 10.1186/1750-1326-6-73.

PMID:
22029574
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology.

Wegorzewska I, Baloh RH.

Neurodegener Dis. 2011;8(4):262-74. doi: 10.1159/000321547. Epub 2010 Dec 3. Review.

PMID:
21124004
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The role of tau in neurodegeneration.

Gendron TF, Petrucelli L.

Mol Neurodegener. 2009 Mar 11;4:13. doi: 10.1186/1750-1326-4-13.

PMID:
19284597
[PubMed]
Free PMC Article
18.

Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.

Liachko NF, Guthrie CR, Kraemer BC.

J Neurosci. 2010 Dec 1;30(48):16208-19. doi: 10.1523/JNEUROSCI.2911-10.2010.

PMID:
21123567
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies.

Cohen TJ, Lee VM, Trojanowski JQ.

Trends Mol Med. 2011 Nov;17(11):659-67. doi: 10.1016/j.molmed.2011.06.004. Epub 2011 Jul 23. Review.

PMID:
21783422
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats.

Tong J, Huang C, Bi F, Wu Q, Huang B, Zhou H.

J Neurochem. 2012 Nov;123(3):406-16. doi: 10.1111/jnc.12014.

PMID:
22970712
[PubMed - indexed for MEDLINE]
Free PMC Article

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