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Items: 1 to 20 of 107

1.

NF-kappaB signaling: multiple angles to target OA.

Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB.

Curr Drug Targets. 2010 May;11(5):599-613. Review.

2.

The NF-κB signalling pathway in osteoarthritis.

Rigoglou S, Papavassiliou AG.

Int J Biochem Cell Biol. 2013 Nov;45(11):2580-4. doi: 10.1016/j.biocel.2013.08.018. Epub 2013 Sep 1. Review.

PMID:
24004831
3.

Insights on biology and pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-catenin, and NF-κB pathways in osteoarthritis.

Wu L, Huang X, Li L, Huang H, Xu R, Luyten W.

Curr Pharm Des. 2012;18(22):3293-312. Review.

PMID:
22646092
4.

IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation.

Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, Flamigni F, Facchini A, Goldring MB, Borzì RM, Marcu KB.

PLoS One. 2013 Sep 2;8(9):e73024. doi: 10.1371/journal.pone.0073024. eCollection 2013.

5.

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, Shakibaei M.

PLoS One. 2011;6(12):e28663. doi: 10.1371/journal.pone.0028663. Epub 2011 Dec 14.

6.

Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes.

Chen YJ, Tsai KS, Chan DC, Lan KC, Chen CF, Yang RS, Liu SH.

J Orthop Res. 2014 Apr;32(4):573-80. doi: 10.1002/jor.22577. Epub 2013 Dec 27.

7.
8.

Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.

Olivotto E, Borzi RM, Vitellozzi R, Pagani S, Facchini A, Battistelli M, Penzo M, Li X, Flamigni F, Li J, Falcieri E, Facchini A, Marcu KB.

Arthritis Rheum. 2008 Jan;58(1):227-39. doi: 10.1002/art.23211. Erratum in: Arthritis Rheum. 2008 Mar;58(3):887.

9.

Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.

PMID:
17047224
10.

To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy.

Blom AB, van Lent PL, van der Kraan PM, van den Berg WB.

Curr Drug Targets. 2010 May;11(5):620-9. Review.

PMID:
20199388
11.

Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M.

Int J Mol Sci. 2012;13(4):4202-32. doi: 10.3390/ijms13044202. Epub 2012 Mar 30. Review.

12.
13.

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, Mische S, Li J, Marcu KB.

J Biol Chem. 2002 Nov 22;277(47):45129-40. Epub 2002 Sep 6.

14.

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation.

Olivotto E, Otero M, Marcu KB, Goldring MB.

RMD Open. 2015 Aug 15;1(Suppl 1):e000061. doi: 10.1136/rmdopen-2015-000061. eCollection 2015. Review.

15.

Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment.

Buhrmann C, Mobasheri A, Matis U, Shakibaei M.

Arthritis Res Ther. 2010;12(4):R127. doi: 10.1186/ar3065. Epub 2010 Jul 1.

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17.

Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.

LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M.

J Biol Chem. 2006 Aug 25;281(34):24124-37. Epub 2006 Jun 23.

18.

Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro.

Cheng CC, Chen YH, Chang WL, Yang SP, Chang DM, Lai JH, Ho LJ.

Eur J Pharmacol. 2010 Jun 25;636(1-3):181-8. doi: 10.1016/j.ejphar.2010.03.031. Epub 2010 Mar 31.

PMID:
20361957
20.

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.

Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L, Hepperle M, Harriman G, Jaffee BD, Ocain TD, Xu Y.

J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001. Epub 2006 Mar 8.

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