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Items: 1 to 20 of 108

1.

Novel benzothiophene H1-antihistamines for the treatment of insomnia.

Moree WJ, Jovic F, Coon T, Yu J, Li BF, Tucci FC, Marinkovic D, Gross RS, Malany S, Bradbury MJ, Hernandez LM, O'Brien Z, Wen J, Wang H, Hoare SR, Petroski RE, Sacaan A, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2316-20. doi: 10.1016/j.bmcl.2010.01.134. Epub 2010 Feb 2.

PMID:
20188547
2.

Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.

Moree WJ, Li BF, Zamani-Kord S, Yu J, Coon T, Huang C, Marinkovic D, Tucci FC, Malany S, Bradbury MJ, Hernandez LM, Wen J, Wang H, Hoare SR, Petroski RE, Jalali K, Yang C, Sacaan A, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5874-8. doi: 10.1016/j.bmcl.2010.07.117. Epub 2010 Aug 3.

PMID:
20800486
3.

Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.

Moree WJ, Li BF, Jovic F, Coon T, Yu J, Gross RS, Tucci F, Marinkovic D, Zamani-Kord S, Malany S, Bradbury MJ, Hernandez LM, O'Brien Z, Wen J, Wang H, Hoare SR, Petroski RE, Sacaan A, Madan A, Crowe PD, Beaton G.

J Med Chem. 2009 Sep 10;52(17):5307-10. doi: 10.1021/jm900933k.

PMID:
19663387
4.

The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.

Lavrador-Erb K, Ravula SB, Yu J, Zamani-Kord S, Moree WJ, Petroski RE, Wen J, Malany S, Hoare SR, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9. doi: 10.1016/j.bmcl.2010.03.027. Epub 2010 Mar 10.

PMID:
20347297
6.

The expanding role of H1 antihistamines: a patent survey of selective and dual activity compounds 2005-2010.

Beaton G, Moree WJ.

Expert Opin Ther Pat. 2010 Sep;20(9):1197-218. doi: 10.1517/13543776.2010.510516. Review.

PMID:
20716024
7.

Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.

Ravula SB, Yu J, Tran JA, Arellano M, Tucci FC, Moree WJ, Li BF, Petroski RE, Wen J, Malany S, Hoare SR, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):421-6. doi: 10.1016/j.bmcl.2011.10.115. Epub 2011 Nov 15.

PMID:
22153347
8.

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.

Aslanian R, Mutahi Mw, Shih NY, Piwinski JJ, West R, Williams SM, She S, Wu RL, Hey JA.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1959-61.

PMID:
12781173
9.

Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6.

Huang C, Moree WJ, Zamani-Kord S, Li BF, Tucci FC, Malany S, Wen J, Wang H, Hoare SR, Yang C, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):947-51. doi: 10.1016/j.bmcl.2010.12.053. Epub 2010 Dec 16.

PMID:
21232954
10.

Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.

Coon T, Moree WJ, Li B, Yu J, Zamani-Kord S, Malany S, Santos MA, Hernandez LM, Petroski RE, Sun A, Wen J, Sullivan S, Haelewyn J, Hedrick M, Hoare SJ, Bradbury MJ, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4380-4. doi: 10.1016/j.bmcl.2009.05.086. Epub 2009 May 27.

PMID:
19553115
11.

Selective histamine H(1) antagonism: a novel approach to insomnia using low-dose doxepin.

Owen RT.

Drugs Today (Barc). 2009 Apr;45(4):261-7. doi: 10.1358/dot.2009.45.4.1358835.

PMID:
19499091
12.
13.

[H1-antihistaminics of the first generation].

Bennack E, Holzgrabe U.

Pharm Unserer Zeit. 2007;36(3):202-4. Review. German. No abstract available.

PMID:
17555056
14.

Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.

Fonquerna S, Miralpeix M, Pagès L, Puig C, Cardús A, Antón F, Cárdenas A, Vilella D, Aparici M, Calaf E, Prieto J, Gras J, Huerta JM, Warrellow G, Beleta J, Ryder H.

J Med Chem. 2004 Dec 2;47(25):6326-37.

PMID:
15566302
15.

[Development, structures, and new trends. H1-antihistamines].

Stark H, Schubert-Zsilavecz M.

Pharm Unserer Zeit. 2004;33(2):92-8. Review. German. No abstract available.

PMID:
15083617
16.

[Substituted 2,3,4,5-tetrahydro-1H-gamma-carbolines: new antagonists of histamine H1 receptors].

Ivashchenko AV, Mit'kin OD, Okun' IM, Salimov RM, Fedotov IuA.

Eksp Klin Farmakol. 2010 Nov;73(11):25-9. Russian.

PMID:
21254595
17.

Preclinical comparison of ebastine and other second generation H1-antihistamines.

Yakuo I, Yabuuchi M, Ito T.

Pharmacol Toxicol. 2001 Oct;89(4):171-6.

PMID:
11881966
18.

Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications.

Krystal AD, Richelson E, Roth T.

Sleep Med Rev. 2013 Aug;17(4):263-72. doi: 10.1016/j.smrv.2012.08.001. Epub 2013 Jan 26. Review.

PMID:
23357028
19.

Pharmacokinetic-pharmacodynamic relationships of H1-antihistamines.

Desager JP, Horsmans Y.

Clin Pharmacokinet. 1995 May;28(5):419-32. Review.

PMID:
7614779
20.

Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia.

Li BF, Moree WJ, Yu J, Coon T, Zamani-Kord S, Malany S, Jalali K, Wen J, Wang H, Yang C, Hoare SR, Petroski RE, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2629-33. doi: 10.1016/j.bmcl.2010.02.055. Epub 2010 Feb 18.

PMID:
20227880
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