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Items: 1 to 20 of 109


Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.

Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE.

Anesthesiology. 2010 Mar;112(3):637-44. doi: 10.1097/ALN.0b013e3181cf40ed.


In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.

Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE.

Anesth Analg. 2012 Aug;115(2):297-304. doi: 10.1213/ANE.0b013e3182320559. Epub 2011 Sep 29.


Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.

Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE.

Anesthesiology. 2009 Aug;111(2):240-9. doi: 10.1097/ALN.0b013e3181ae63d1.


Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.

Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE.

Anesthesiology. 2011 Oct;115(4):764-73. doi: 10.1097/ALN.0b013e31821950de.


Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.

Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE.

Crit Care Med. 2012 Jan;40(1):187-92. doi: 10.1097/CCM.0b013e31822d7924.


Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.

Pejo E, Santer P, Jeffrey S, Gallin H, Husain SS, Raines DE.

Anesthesiology. 2014 Aug;121(2):290-301. doi: 10.1097/ALN.0000000000000268.


The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.

Desai R, Miller KW, Raines DE.

Anesth Analg. 2013 Mar;116(3):573-9. doi: 10.1213/ANE.0b013e31827d204d. Epub 2013 Feb 11.


Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite.

Ge RL, Pejo E, Haburcak M, Husain SS, Forman SA, Raines DE.

Anesth Analg. 2012 Aug;115(2):305-8. doi: 10.1213/ANE.0b013e318239c6ca. Epub 2011 Nov 3.


Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase.

Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE.

Anesth Analg. 2013 Jun;116(6):1249-56. doi: 10.1213/ANE.0b013e31828b3637. Epub 2013 Mar 14.


Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.

Pierce DW, Pejo E, Raines DE, Forman SA.

Anesth Analg. 2012 Jul;115(1):70-2. doi: 10.1213/ANE.0b013e318254273e. Epub 2012 Apr 27.


Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.

Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE.

Anesthesiology. 2014 Dec;121(6):1203-16. doi: 10.1097/ALN.0000000000000416.


The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia.

Belelli D, Muntoni AL, Merrywest SD, Gentet LJ, Casula A, Callachan H, Madau P, Gemmell DK, Hamilton NM, Lambert JJ, Sillar KT, Peters JA.

Neuropharmacology. 2003 Jul;45(1):57-71.


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.

Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G.

Br J Pharmacol. 2014 Dec;171(23):5446-57. doi: 10.1111/bph.12861.


Clinical and molecular pharmacology of etomidate.

Forman SA.

Anesthesiology. 2011 Mar;114(3):695-707. doi: 10.1097/ALN.0b013e3181ff72b5. Review.


p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.

Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW.

J Med Chem. 2010 Sep 9;53(17):6432-44. doi: 10.1021/jm100498u.


Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.

Husain SS, Pejo E, Ge R, Raines DE.

Anesthesiology. 2012 Nov;117(5):1027-36. doi: 10.1097/ALN.0b013e31826d3bef.


Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity.

Desai R, Ruesch D, Forman SA.

Anesthesiology. 2009 Oct;111(4):774-84. doi: 10.1097/ALN.0b013e3181b55fae.


Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.

Guitchounts G, Stewart DS, Forman SA.

Anesthesiology. 2012 Jun;116(6):1235-44. doi: 10.1097/ALN.0b013e3182567df3.


Novel etomidate derivatives.

Sneyd JR.

Curr Pharm Des. 2012;18(38):6253-6. Review.

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