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Results: 1 to 20 of 96

1.

Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.

Bernardo PH, Sivaraman T, Wan KF, Xu J, Krishnamoorthy J, Song CM, Tian L, Chin JS, Lim DS, Mok HY, Yu VC, Tong JC, Chai CL.

J Med Chem. 2010 Mar 11;53(5):2314-8. doi: 10.1021/jm901469p.

PMID:
20158203
[PubMed - indexed for MEDLINE]
2.

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

Enyedy IJ, Ling Y, Nacro K, Tomita Y, Wu X, Cao Y, Guo R, Li B, Zhu X, Huang Y, Long YQ, Roller PP, Yang D, Wang S.

J Med Chem. 2001 Dec 6;44(25):4313-24.

PMID:
11728179
[PubMed - indexed for MEDLINE]
3.

Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents.

Aliabadi A, Shamsa F, Ostad SN, Emami S, Shafiee A, Davoodi J, Foroumadi A.

Eur J Med Chem. 2010 Nov;45(11):5384-9. doi: 10.1016/j.ejmech.2010.08.063. Epub 2010 Sep 16.

PMID:
20846760
[PubMed - indexed for MEDLINE]
4.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.

Horiuchi T, Nagata M, Kitagawa M, Akahane K, Uoto K.

Bioorg Med Chem. 2009 Dec 1;17(23):7850-60. doi: 10.1016/j.bmc.2009.10.039. Epub 2009 Oct 24.

PMID:
19889545
[PubMed - indexed for MEDLINE]
5.

Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.

Lavecchia A, Di Giovanni C, Pesapane A, Montuori N, Ragno P, Martucci NM, Masullo M, De Vendittis E, Novellino E.

J Med Chem. 2012 May 10;55(9):4142-58. doi: 10.1021/jm201624h. Epub 2012 May 1.

PMID:
22524450
[PubMed - indexed for MEDLINE]
6.

Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.

Bernardo PH, Wan KF, Sivaraman T, Xu J, Moore FK, Hung AW, Mok HY, Yu VC, Chai CL.

J Med Chem. 2008 Nov 13;51(21):6699-710. doi: 10.1021/jm8005433. Epub 2008 Oct 17.

PMID:
18925736
[PubMed - indexed for MEDLINE]
7.

Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.

Zhang Z, Yang H, Wu G, Li Z, Song T, Li XQ.

Eur J Med Chem. 2011 Sep;46(9):3909-16. doi: 10.1016/j.ejmech.2011.05.062. Epub 2011 May 31.

PMID:
21684048
[PubMed - indexed for MEDLINE]
8.

The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1.

Prakesch M, Denisov AY, Naim M, Gehring K, Arya P.

Bioorg Med Chem. 2008 Aug 1;16(15):7443-9. doi: 10.1016/j.bmc.2008.06.023. Epub 2008 Jun 18.

PMID:
18603434
[PubMed - indexed for MEDLINE]
9.

Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity.

Zhang Y, Zhong H, Wang T, Geng D, Zhang M, Li K.

Eur J Med Chem. 2012 Feb;48:69-80. doi: 10.1016/j.ejmech.2011.11.036. Epub 2011 Dec 1.

PMID:
22182926
[PubMed - indexed for MEDLINE]
10.

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M.

J Med Chem. 2003 Sep 25;46(20):4259-64.

PMID:
13678404
[PubMed - indexed for MEDLINE]
11.

Synthesis and biological evaluation of new 4-thiazolidinone derivatives.

Güzel O, Salman A.

J Enzyme Inhib Med Chem. 2009 Aug;24(4):1015-23. doi: 10.1080/14756360802608021.

PMID:
19624255
[PubMed - indexed for MEDLINE]
12.

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.

Qian J, Voorbach MJ, Huth JR, Coen ML, Zhang H, Ng SC, Comess KM, Petros AM, Rosenberg SH, Warrior U, Burns DJ.

Anal Biochem. 2004 May 15;328(2):131-8.

PMID:
15113688
[PubMed - indexed for MEDLINE]
13.

Novel nontoxic heat shock protein 90 inhibitors having selective antiproliferative effect.

Orosz A, Szabo A, Szeman G, Janaky T, Somlai C, Penke B, Bodor A, Perczel A.

Int J Biochem Cell Biol. 2006;38(8):1352-62. Epub 2006 Feb 28.

PMID:
16540363
[PubMed - indexed for MEDLINE]
14.

Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.

Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW.

J Med Chem. 2013 Jan 10;56(1):15-30. doi: 10.1021/jm301448p. Epub 2012 Dec 17.

PMID:
23244564
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Wang YS, Strickland C, Voigt JH, Kennedy ME, Beyer BM, Senior MM, Smith EM, Nechuta TL, Madison VS, Czarniecki M, McKittrick BA, Stamford AW, Parker EM, Hunter JC, Greenlee WJ, Wyss DF.

J Med Chem. 2010 Feb 11;53(3):942-50. doi: 10.1021/jm901472u.

PMID:
20043700
[PubMed - indexed for MEDLINE]
16.

Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.

Zhang YH, Bhunia A, Wan KF, Lee MC, Chan SL, Yu VC, Mok YK.

J Mol Biol. 2006 Dec 1;364(3):536-49. Epub 2006 Sep 14.

PMID:
17011577
[PubMed - indexed for MEDLINE]
17.

Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents.

Liu XH, Liu HF, Shen X, Song BA, Bhadury PS, Zhu HL, Liu JX, Qi XB.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4163-7. doi: 10.1016/j.bmcl.2010.05.080. Epub 2010 May 24.

PMID:
20538457
[PubMed - indexed for MEDLINE]
18.

Platinum(II) compounds with chelating ligands based on pyridine and pyrimidine: synthesis, characterizations, DFT calculations, cytotoxic assays and binding to a DNA model base.

Roy S, Westmaas JA, Buda F, Reedijk J.

J Inorg Biochem. 2009 Sep;103(9):1278-87. doi: 10.1016/j.jinorgbio.2009.07.004. Epub 2009 Aug 4.

PMID:
19656572
[PubMed - indexed for MEDLINE]
19.

2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents.

Azizmohammadi M, Khoobi M, Ramazani A, Emami S, Zarrin A, Firuzi O, Miri R, Shafiee A.

Eur J Med Chem. 2013 Jan;59:15-22. doi: 10.1016/j.ejmech.2012.10.044. Epub 2012 Nov 2.

PMID:
23202485
[PubMed - indexed for MEDLINE]
20.

Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites.

Tomašić T, Kovač A, Simčič M, Blanot D, Grdadolnik SG, Gobec S, Kikelj D, Peterlin Mašič L.

Eur J Med Chem. 2011 Sep;46(9):3964-75. doi: 10.1016/j.ejmech.2011.05.070. Epub 2011 Jun 23.

PMID:
21703731
[PubMed - indexed for MEDLINE]

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