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20153624,20938484,20149621,17197552,23954767,21044678,18367636,24008411,23901249,31865348,21937211,20463317,19837064,19136057,25975662,15896789,23000247,21656369,26030919,18258206,16979807,21663493,19671018,20933534,18463988,18654882,15256227,33101585,19596284,28761325,26878773,19710412,19759330,19838946,11309284,18616940,18709653,26188148,16723490,28103505,19374873,22827614,30502459,25304969,19524565,19083475,19451092,25934285,17980396,16850181,15965958,21622943,20555145,24460843,20565308,23901044,24810054,17935293,31430968,23651647,21850179,20007347,30820141,28665123,29524384,33535179,19436138,27155396,29274434,36976187,22301773,26781848,26482868,28105249,34685615,33040597,22474169,33472699,23343353,19117929,21887458,24530478,30584457,35302431,26241392,16480751,18385090,31257945,30216854,33435366,20060927,23448276,15082063,29297235,30269355,34037025,23861227,28765097,31035147,31659585,25619973,25722027,18566994,23121080,34664771,23079631,19656028,21793311,32412821,26899469,31118030,20565311,24428990,18806289,29697268,27616142,28707481,22730333,23061789,23862688,34313391,31039616,28763303,27827892,31345961,28286015,26890747,23046382,30404999,27774118,22549309,30117083,29973491,19959636,30524663,32192228,21087962,33079459,34064070,31887452,31157476,32482385,16249512,15229324,26219933,25939783,25981918,22380882,22915767,24111857,28132522,25637740,22851277,24593876,23046500,27754362,16153622,22261284,29459695,16594172,12084617,33374795,19176875,23404113,24905050,24454990,31556307,29393642,23485938,16363144,28600747,36372214,24026667,28782506,21216240,22975494,37028452,31868938,16984736,30885167,27966724,27743160,29258224,26643168,34080202,28942193,12566129,26310342,27288283,11752465,26427395,28969450,30870514,24241266,17055614,28342966,16116181,11706044,16706653,11375902,28159594,25662315,21457933,19873881,29486165,27020660,15607645,27897980,37153596,23026831,30346763,20879805,25385631,29653456,18180306,36190376,28503967,22035889,32286500,21469739,31122072,24613837,33450344,33359686,27505139,26808544,32582966,32033116,29606027,24667599,30628023,34237733,24444448,23065278,21539383,22752767,25091899,21309688,11788155,25701434,23994576,26205038,23743302,23898883,22829200,18928848,18242194,34238125,28786049,18959033,15209416,19651797,32498245,25395196,12915223,34954022,17561088,19839867,19188863,36997025,30668393,23578477,21091848,22924673,33398525,18445980,36226819,30320359,15191057,28109747,19548348,29456784,12569582,29427790,22560834,34942973,24847785,33773776,24192042,18385089,34282996,26624556,24492497,26010708,29169345,19115203,26749581,20020979,24020814,32920040,15752714,23747930,28429215,17124605,28961056,21726176,22879419,31820335,25428670,29802900,26717313,18327872,30068286,17541743,19263520,33774859,11970840,20153084,25619908,35203712,25032851,33233661,10079053,20657484,29248694,22985735,29186981,24066918,19784391,25811373,23190112,20020980,21863476,21504135,34908224,10391143,24428674,32229256,33374239,30257402,34222291,36077335,29158871,29230174,26461383,16903078,20387640,15147781,30211983,28706328,22953919,22495657,12959415,21249230,20538604,27123904,18488508,18482591,33421550,34021828,24319746,35058783,27478470,25628402,22354407,31672277,10227855,30671620,21822532,26968401,18410524,33578233,28447530,29886754,17634630,33848378,23920314,12180195,26427490,18163102,23000755,35381271,34829643,16008098,28613284,21732153,32632968,8954326,22132835,29564938,32793937,33918063,28482051,30325253,11084283,19624272,25872265,11216505,15613000,33572785,10366767,31131603,20015449,17250676,17995940,26601842,24905350,29792731,18969493,21823221,12235059,23055666,30587690,19390643,12126965,30654434,32684091,30455645,22486439,30459744,31780296,35740030,14715435,30654934,15795416,33920659,34232243,18789671,29344958,12604195,30572579,20336011,27406963,14676331,25517103,30604966,32530271,26118693,33114498,19911007,30110365,24319591,16027864,32469275,35940803,36806656,23341934,25909053,10966506,12774921,25018761,17886430,32821515,36552648,34111255,18282682,16814530,29392756,28933402,36552530,36756732,33255669,17382327,29163788,35777688,8100484,36359372,33511517,32110961,36752871,30479711,7513061,34439544,2195554,20309663,25971278,29348770,27690013,25551340,32198188,24174154,25694172,33907376,24900356,20692905,17970710,32486078,34834230,32492782[uid]

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α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells.

Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J. Feng Z, et al. J Nutr Biochem. 2010 Dec;21(12):1222-31. doi: 10.1016/j.jnutbio.2009.10.010. Epub 2010 Feb 12. J Nutr Biochem. 2010. PMID: 20153624

Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction.

Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, Liu J. Liu Z, et al. J Neurochem. 2007 Dec;103(6):2690-700. doi: 10.1111/j.1471-4159.2007.04954.x. J Neurochem. 2007. PMID: 20938484 Free PMC article.

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells.

Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi X, Liu J. Zhu L, et al. J Nutr Biochem. 2010 Nov;21(11):1089-98. doi: 10.1016/j.jnutbio.2009.09.006. Epub 2010 Feb 9. J Nutr Biochem. 2010. PMID: 20149621

Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.

Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J. Jia L, et al. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):339-48. doi: 10.1167/iovs.06-0248. Invest Ophthalmol Vis Sci. 2007. PMID: 17197552 Free PMC article.

Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity.

Li Y, Zou X, Cao K, Xu J, Yue T, Dai F, Zhou B, Lu W, Feng Z, Liu J. Li Y, et al. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):726-35. doi: 10.1016/j.taap.2013.07.029. Epub 2013 Aug 13. Toxicol Appl Pharmacol. 2013. PMID: 23954767

Diarylheptanoid 7-(3,4 dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene from Curcuma comosa Roxb. protects retinal pigment epithelial cells against oxidative stress-induced cell death.

Jitsanong T, Khanobdee K, Piyachaturawat P, Wongprasert K. Jitsanong T, et al. Toxicol In Vitro. 2011 Feb;25(1):167-76. doi: 10.1016/j.tiv.2010.10.014. Epub 2010 Oct 31. Toxicol In Vitro. 2011. PMID: 21044678

Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stress.

Zhu H, Jia Z, Zhang L, Yamamoto M, Misra HP, Trush MA, Li Y. Zhu H, et al. Exp Biol Med (Maywood). 2008 Apr;233(4):463-74. doi: 10.3181/0711-RM-304. Exp Biol Med (Maywood). 2008. PMID: 18367636

Resveratrol stimulates mitochondrial bioenergetics to protect retinal pigment epithelial cells from oxidative damage.

Sheu SJ, Liu NC, Ou CC, Bee YS, Chen SC, Lin HC, Chan JY. Sheu SJ, et al. Invest Ophthalmol Vis Sci. 2013 Sep 27;54(9):6426-38. doi: 10.1167/iovs.13-12024. Invest Ophthalmol Vis Sci. 2013. PMID: 24008411

Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.

Li Z, Dong X, Liu H, Chen X, Shi H, Fan Y, Hou D, Zhang X. Li Z, et al. Mol Vis. 2013 Jul 25;19:1656-66. Print 2013. Mol Vis. 2013. PMID: 23901249 Free PMC article.

Exendin-4 Protects Human Retinal Pigment Epithelial Cells from H2O2-Induced Oxidative Damage via Activation of NRF2 Signaling.

Cui R, Tian L, Lu D, Li H, Cui J. Cui R, et al. Ophthalmic Res. 2020;63(4):404-412. doi: 10.1159/000504891. Epub 2019 Dec 20. Ophthalmic Res. 2020. PMID: 31865348

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