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Local protease signaling contributes to neural tube closure in the mouse embryo.

Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR.

Dev Cell. 2010 Jan 19;18(1):25-38. doi: 10.1016/j.devcel.2009.11.014.


Defining a PARticular pathway of neural tube closure.

Copp AJ, Greene ND.

Dev Cell. 2010 Jan 19;18(1):1-2. doi: 10.1016/j.devcel.2010.01.002.


PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.

McCoy KL, Traynelis SF, Hepler JR.

Mol Pharmacol. 2010 Jun;77(6):1005-15. doi: 10.1124/mol.109.062018. Epub 2010 Mar 9.


Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells.

Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J.

Cancer Res. 2006 Jan 1;66(1):307-14.


Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.

Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH.

PLoS Genet. 2012;8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30.


Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro.

Banfi C, Brioschi M, Lento S, Pirillo A, Galli S, Cosentino S, Tremoli E, Mussoni L.

J Thromb Haemost. 2011 Aug;9(8):1608-19. doi: 10.1111/j.1538-7836.2011.04366.x.


Modulation of expression of innate immunity markers CXCL5/ENA-78 and CCL20/MIP3alpha by protease-activated receptors (PARs) in human gingival epithelial cells.

Rohani MG, Beyer RP, Hacker BM, Dommisch H, Dale BA, Chung WO.

Innate Immun. 2010 Apr;16(2):104-14. doi: 10.1177/1753425909339233. Epub 2009 Jun 30.


Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer.

Jaber M, Maoz M, Kancharla A, Agranovich D, Peretz T, Grisaru-Granovsky S, Uziely B, Bar-Shavit R.

Cell Mol Life Sci. 2014 Jul;71(13):2517-33. doi: 10.1007/s00018-013-1498-7. Epub 2013 Nov 1.


Expression of protease-activated receptor 1 and 2 and anti-tubulogenic activity of protease-activated receptor 1 in human endothelial colony-forming cells.

Fortunato TM, Vara DS, Wheeler-Jones CP, Pula G.

PLoS One. 2014 Oct 7;9(10):e109375. doi: 10.1371/journal.pone.0109375. eCollection 2014.


Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice.

Versteeg HH, Schaffner F, Kerver M, Ellies LG, Andrade-Gordon P, Mueller BM, Ruf W.

Cancer Res. 2008 Sep 1;68(17):7219-27. doi: 10.1158/0008-5472.CAN-08-0419.


Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.

Szabo R, Hobson JP, Christoph K, Kosa P, List K, Bugge TH.

Development. 2009 Aug;136(15):2653-63. doi: 10.1242/dev.038430.


The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

Disse J, Petersen HH, Larsen KS, Persson E, Esmon N, Esmon CT, Teyton L, Petersen LC, Ruf W.

J Biol Chem. 2011 Feb 18;286(7):5756-67. doi: 10.1074/jbc.M110.201228. Epub 2010 Dec 13.


Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling.

Lin H, Trejo J.

J Biol Chem. 2013 Apr 19;288(16):11203-15. doi: 10.1074/jbc.M112.439950. Epub 2013 Mar 8.


Notch signaling maintains neural rosette polarity.

Main H, Radenkovic J, Jin SB, Lendahl U, Andersson ER.

PLoS One. 2013 May 10;8(5):e62959. doi: 10.1371/journal.pone.0062959. Print 2013.


Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity.

Kee N, Wilson N, De Vries M, Bradford D, Key B, Cooper HM.

J Neurosci. 2008 Nov 26;28(48):12643-53. doi: 10.1523/JNEUROSCI.4265-08.2008.


Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis.

Uusitalo-Jarvinen H, Kurokawa T, Mueller BM, Andrade-Gordon P, Friedlander M, Ruf W.

Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1456-62. Epub 2007 Mar 15.


Constitutive expression of functionally active protease-activated receptors 1 and 2 in human conjunctival epithelial cells.

Nickel TJ, Kabir MH, Talreja J, Stechschulte DJ, Dileepan KN.

Mediators Inflamm. 2006;2006(3):61359.


Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

Ramachandran R, Sadofsky LR, Xiao Y, Botham A, Cowen M, Morice AH, Compton SJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L788-98. Epub 2006 Dec 1.


The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.

Zohn IE, Anderson KV, Niswander L.

Dev Biol. 2007 Jun 1;306(1):208-21. Epub 2007 Mar 20.

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