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Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.

Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD.

Cancer Res. 2010 Feb 15;70(4):1564-72. doi: 10.1158/0008-5472.CAN-09-3228. Epub 2010 Feb 9.


Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8215-20. doi: 10.1073/pnas.0708100105. Epub 2008 Mar 31.


Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression.

Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD.

Exp Gerontol. 2013 Oct;48(10):1120-8. doi: 10.1016/j.exger.2013.02.016. Epub 2013 Feb 21.


Postprandial changes in plasma growth hormone, insulin, insulin-like growth factor (IGF)-I, and IGF-binding proteins in coho salmon fasted for varying periods.

Shimizu M, Cooper KA, Dickhoff WW, Beckman BR.

Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R352-61. doi: 10.1152/ajpregu.90939.2008. Epub 2009 May 27.


Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou).

Kawaguchi K, Kaneko N, Fukuda M, Nakano Y, Kimura S, Hara A, Shimizu M.

Comp Biochem Physiol A Mol Integr Physiol. 2013 Jun;165(2):191-8. doi: 10.1016/j.cbpa.2013.02.029. Epub 2013 Mar 6.


Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice.

Lewitt MS, Brismar K, Wang J, Wivall-Helleryd IL, Sindelar P, Gonzalez FJ, Bergman T, Bobek GA.

Growth Horm IGF Res. 2001 Oct;11(5):303-13.


Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

Diabetes. 2001 May;50(5):1110-8.


Starvation, detoxification, and multidrug resistance in cancer therapy.

Lee C, Raffaghello L, Longo VD.

Drug Resist Updat. 2012 Feb-Apr;15(1-2):114-22. doi: 10.1016/j.drup.2012.01.004. Epub 2012 Mar 4. Review.


Fasting enhances the response of glioma to chemo- and radiotherapy.

Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD.

PLoS One. 2012;7(9):e44603. doi: 10.1371/journal.pone.0044603. Epub 2012 Sep 11.


Effects of fasting on IGF-I, IGF-II, and IGF-binding protein mRNA concentrations in channel catfish (Ictalurus punctatus).

Peterson BC, Waldbieser GC.

Domest Anim Endocrinol. 2009 Aug;37(2):74-83. doi: 10.1016/j.domaniend.2009.03.004. Epub 2009 May 3.


Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.

Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD.

Sci Transl Med. 2012 Mar 7;4(124):124ra27. doi: 10.1126/scitranslmed.3003293. Epub 2012 Feb 8.


The effect of epidermal growth factor on circulating levels of free and total IGF-I and IGF-binding proteins in adult rats.

Frystyk J, Vinter-Jensen L, Skjaerbaek C, Flyvbjerg A.

Growth Regul. 1996 Mar;6(1):48-54.


Starvation based differential chemotherapy: 
a novel approach for cancer treatment.

Naveed S, Aslam M, Ahmad A.

Oman Med J. 2014 Nov;29(6):391-8. doi: 10.5001/omj.2014.107. Review.


The IGF-I/IGFBP system in congenital partial lipodystrophy.

Janssen JA, Hoogerbrugge N, van Neck JW, Uitterlinden P, Lamberts SW.

Clin Endocrinol (Oxf). 1998 Oct;49(4):465-73.


Changes in the circulating IGF system during short-term fasting and refeeding in rats.

Frystyk J, Delhanty PJ, Skjaerbaek C, Baxter RC.

Am J Physiol. 1999 Aug;277(2 Pt 1):E245-52.


The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C.

Endocrinology. 2015 Dec;156(12):4511-21. doi: 10.1210/en.2015-1542. Epub 2015 Sep 18.


The study of spontaneous GH secretion after 36-h fasting distinguishes between GH-deficient and normal adults.

Aimaretti G, Colao A, Corneli G, Pivonello R, MacCario M, Morrison K, Pflaum CD, Strasburger CJ, Lombardi G, Ghigo E.

Clin Endocrinol (Oxf). 1999 Dec;51(6):771-7.


Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.

Lee C, Longo VD.

Oncogene. 2011 Jul 28;30(30):3305-16. doi: 10.1038/onc.2011.91. Epub 2011 Apr 25. Review.


Serum levels of IGF-1 and IGFBP-3 during adjuvant chemotherapy for primary breast cancer.

Fürstenberger G, Senn E, Morant R, Bolliger B, Senn HJ.

Breast. 2006 Feb;15(1):64-8. Epub 2005 Jul 5.

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