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Items: 1 to 20 of 106

1.

Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies.

Niu C, Ho DM, Williamson RT, Zask A, Ayral-Kaloustian S.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1535-8. doi: 10.1016/j.bmcl.2010.01.047. Epub 2010 Jan 20. Erratum in: Bioorg Med Chem Lett. 2012 Mar 1;22(5):2131. Williamson, Robert Thomas [added].

PMID:
20137930
2.

Structure-based identification of the binding site for the hemiasterlin analogue HTI-286 on tubulin.

Ravi M, Zask A, Rush TS 3rd.

Biochemistry. 2005 Dec 6;44(48):15871-9.

PMID:
16313189
3.

Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents.

Zask A, Kaplan J, Musto S, Loganzo F.

J Am Chem Soc. 2005 Dec 21;127(50):17667-71.

PMID:
16351096
4.

Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria.

Steinmetz H, Glaser N, Herdtweck E, Sasse F, Reichenbach H, Höfle G.

Angew Chem Int Ed Engl. 2004 Sep 20;43(37):4888-92. No abstract available.

PMID:
15372566
5.

Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules.

Krishnamurthy G, Cheng W, Lo MC, Aulabaugh A, Razinkov V, Ding W, Loganzo F, Zask A, Ellestad G.

Biochemistry. 2003 Nov 25;42(46):13484-95.

PMID:
14621994
6.

Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.

Yamashita A, Norton EB, Kaplan JA, Niu C, Loganzo F, Hernandez R, Beyer CF, Annable T, Musto S, Discafani C, Zask A, Ayral-Kaloustian S.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5317-22.

PMID:
15454219
7.

Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

Bennani YL, Gu W, Canales A, Díaz FJ, Eustace BK, Hoover RR, Jiménez-Barbero J, Nezami A, Wang T.

J Med Chem. 2012 Mar 8;55(5):1920-5. doi: 10.1021/jm200848t. Epub 2012 Feb 27.

PMID:
22320354
8.
9.

Probing the interaction of HTI-286 with tubulin using a stilbene analogue.

Lo MC, Aulabaugh A, Krishnamurthy G, Kaplan J, Zask A, Smith RP, Ellestad G.

J Am Chem Soc. 2004 Aug 18;126(32):9898-9.

PMID:
15303845
10.

Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.

Shibue T, Okamoto I, Morita N, Morita H, Hirasawa Y, Hosoya T, Tamura O.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):431-4. doi: 10.1016/j.bmcl.2010.10.118. Epub 2010 Oct 30.

PMID:
21106374
11.

Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.

Niu C, Smith D, Zask A, Loganzo F, Discafani C, Beyer C, Greenberger L, Ayral-Kaloustian S.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4329-32.

PMID:
15261296
12.

Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents.

Qian Y, Ma GY, Yang Y, Cheng K, Zheng QZ, Mao WJ, Shi L, Zhao J, Zhu HL.

Bioorg Med Chem. 2010 Jun 15;18(12):4310-6. doi: 10.1016/j.bmc.2010.04.091. Epub 2010 May 20.

PMID:
20493717
14.

Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.

Kim ND, Park ES, Kim YH, Moon SK, Lee SS, Ahn SK, Yu DY, No KT, Kim KH.

Bioorg Med Chem. 2010 Oct 1;18(19):7092-100. doi: 10.1016/j.bmc.2010.07.072. Epub 2010 Aug 6.

PMID:
20810285
15.

Structure and absolute stereochemistry of 21-hydroxyoligomycin A.

Wagenaar MM, Williamson RT, Ho DM, Carter GT.

J Nat Prod. 2007 Mar;70(3):367-71. Epub 2007 Jan 24.

PMID:
17249728
16.

Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.

Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM.

Mol Cancer Ther. 2004 Oct;3(10):1319-27.

17.

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.

Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH.

Science. 2004 Aug 6;305(5685):866-9.

18.

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.

Poruchynsky MS, Kim JH, Nogales E, Annable T, Loganzo F, Greenberger LM, Sackett DL, Fojo T.

Biochemistry. 2004 Nov 9;43(44):13944-54.

PMID:
15518543
19.

Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy.

Milton MJ, Thomas Williamson R, Koehn FE.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4279-82. Epub 2006 Jun 12.

PMID:
16765596
20.

Structure and absolute stereochemistry of fusaproliferin, a toxic metabolite from Fusarium proliferatum.

Santini A, Ritieni A, Fogliano V, Randazzo G, Mannina L, Logrieco A, Benedetti E.

J Nat Prod. 1996 Feb;59(2):109-12.

PMID:
8991945
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