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Items: 1 to 20 of 102

1.

Identification and functional characterization of a novel acetylcholine-binding protein from the marine annelid Capitella teleta.

McCormack T, Petrovich RM, Mercier KA, DeRose EF, Cuneo MJ, Williams J, Johnson KL, Lamb PW, London RE, Yakel JL.

Biochemistry. 2010 Mar 16;49(10):2279-87. doi: 10.1021/bi902023y.

3.

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK.

Nature. 2001 May 17;411(6835):269-76.

PMID:
11357122
4.

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein.

Billen B, Spurny R, Brams M, van Elk R, Valera-Kummer S, Yakel JL, Voets T, Bertrand D, Smit AB, Ulens C.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9173-8. doi: 10.1073/pnas.1116397109. Epub 2012 May 22.

5.

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.

Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ.

EMBO J. 2007 Aug 22;26(16):3858-67. Epub 2007 Jul 26.

6.

A model for short alpha-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica: comparison with long-chain alpha-neurotoxins and alpha-conotoxins.

Mordvintsev DY, Polyak YL, Levtsova OV, Tourleigh YV, Kasheverov IE, Shaitan KV, Utkin YN, Tsetlin VI.

Comput Biol Chem. 2005 Dec;29(6):398-411. Epub 2005 Nov 11.

PMID:
16290328
7.

Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop.

Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM.

Mol Pharmacol. 2006 Oct;70(4):1230-5. Epub 2006 Jul 17.

8.

Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry.

Shi J, Koeppe JR, Komives EA, Taylor P.

J Biol Chem. 2006 Apr 28;281(17):12170-7. Epub 2006 Feb 16.

9.

Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.

Zouridakis M, Zisimopoulou P, Eliopoulos E, Poulas K, Tzartos SJ.

Biochim Biophys Acta. 2009 Feb;1794(2):355-66. doi: 10.1016/j.bbapap.2008.11.002. Epub 2008 Nov 19.

PMID:
19059502
10.

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein.

Brams M, Gay EA, Sáez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C.

J Biol Chem. 2011 Feb 11;286(6):4420-8. doi: 10.1074/jbc.M110.188730. Epub 2010 Nov 29.

11.

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

Brejc K, van Dijk WJ, Smit AB, Sixma TK.

Novartis Found Symp. 2002;245:22-9; discussion 29-32, 165-8. Review.

PMID:
12027010
12.

Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor.

Kasheverov IE, Zhmak MN, Fish A, Rucktooa P, Khruschov AY, Osipov AV, Ziganshin RH, D'hoedt D, Bertrand D, Sixma TK, Smit AB, Tsetlin VI.

J Neurochem. 2009 Nov;111(4):934-44. doi: 10.1111/j.1471-4159.2009.06359.x. Epub 2009 Aug 27.

13.

Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors.

Smit AB, Celie PH, Kasheverov IE, Mordvintsev DY, van Nierop P, Bertrand D, Tsetlin V, Sixma TK.

J Mol Neurosci. 2006;30(1-2):9-10.

PMID:
17192605
14.

Insight in nAChR subtype selectivity from AChBP crystal structures.

Rucktooa P, Smit AB, Sixma TK.

Biochem Pharmacol. 2009 Oct 1;78(7):777-87. doi: 10.1016/j.bcp.2009.06.098. Epub 2009 Jul 1. Review.

PMID:
19576182
15.

Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.

Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz Á, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV.

J Am Chem Soc. 2012 Apr 18;134(15):6732-40. doi: 10.1021/ja3001858. Epub 2012 Apr 6.

16.
17.

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.

Armishaw C, Jensen AA, Balle T, Clark RJ, Harpsøe K, Skonberg C, Liljefors T, Strømgaard K.

J Biol Chem. 2009 Apr 3;284(14):9498-512. doi: 10.1074/jbc.M806136200. Epub 2009 Jan 8.

18.

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ.

J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g.

PMID:
19331415
19.

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.

Geitmann M, Retra K, de Kloe GE, Homan E, Smit AB, de Esch IJ, Danielson UH.

Biochemistry. 2010 Sep 21;49(37):8143-54. doi: 10.1021/bi1006354.

PMID:
20701394
20.

Gating of nicotinic ACh receptors: latest insights into ligand binding and function.

Yakel JL.

J Physiol. 2010 Feb 15;588(Pt 4):597-602. doi: 10.1113/jphysiol.2009.182691. Epub 2009 Nov 16. Review.

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