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Items: 1 to 20 of 133

1.

Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.

Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL.

Mol Biol Cell. 2010 Apr 1;21(7):1166-77. doi: 10.1091/mbc.E09-08-0689. Epub 2010 Feb 3.

2.

Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells.

Caruso JA, Campana R, Wei C, Su CH, Hanks AM, Bornmann WG, Keyomarsi K.

Cell Cycle. 2014;13(16):2587-99. doi: 10.4161/15384101.2015.942210.

3.

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.

Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL.

Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21.

4.

Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

Marconett CN, Singhal AK, Sundar SN, Firestone GL.

Mol Cell Endocrinol. 2012 Nov 5;363(1-2):74-84. doi: 10.1016/j.mce.2012.07.008. Epub 2012 Jul 24.

5.

1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Chem Biol Interact. 2010 Aug 5;186(3):255-66. doi: 10.1016/j.cbi.2010.05.015. Epub 2010 Jun 2.

6.

Effects of analogs of indole-3-carbinol cyclic trimerization product in human breast cancer cells.

Xue L, Schaldach CM, Janosik T, Bergman J, Bjeldanes LF.

Chem Biol Interact. 2005 Apr 15;152(2-3):119-29.

PMID:
15840385
7.

Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.

Sundar SN, Kerekatte V, Equinozio CN, Doan VB, Bjeldanes LF, Firestone GL.

Mol Endocrinol. 2006 Dec;20(12):3070-82. Epub 2006 Aug 10.

PMID:
16901971
8.
10.

Inhibition of aryl hydrocarbon receptor-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor α expression in human breast cancer cells.

Macpherson L, Matthews J.

Cancer Lett. 2010 Dec 28;299(2):119-29. doi: 10.1016/j.canlet.2010.08.010. Epub 2010 Sep 16.

PMID:
20846786
11.

Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription.

Wihlén B, Ahmed S, Inzunza J, Matthews J.

Mol Cancer Res. 2009 Jun;7(6):977-86. doi: 10.1158/1541-7786.MCR-08-0396. Epub 2009 May 26.

12.

Estrogen receptor alpha as a target for indole-3-carbinol.

Wang TT, Milner MJ, Milner JA, Kim YS.

J Nutr Biochem. 2006 Oct;17(10):659-64. Epub 2005 Nov 28.

PMID:
16488130
13.
14.

Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells.

Zhang H, Xie X, Zhu X, Zhu J, Hao C, Lu Q, Ding L, Liu Y, Zhou L, Liu Y, Huang C, Wen C, Ye Q.

J Biol Chem. 2005 Dec 30;280(52):43188-97. Epub 2005 Oct 11.

15.

Interaction of glucocorticoid receptor (GR) with estrogen receptor (ER) α and activator protein 1 (AP1) in dexamethasone-mediated interference of ERα activity.

Karmakar S, Jin Y, Nagaich AK.

J Biol Chem. 2013 Aug 16;288(33):24020-34. doi: 10.1074/jbc.M113.473819. Epub 2013 Jun 28.

16.

Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol.

Marques M, Laflamme L, Benassou I, Cissokho C, Guillemette B, Gaudreau L.

BMC Cancer. 2014 Jul 21;14:524. doi: 10.1186/1471-2407-14-524.

17.

Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S.

Mol Endocrinol. 2006 Sep;20(9):2199-214. Epub 2006 May 4.

PMID:
16675542
18.

FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2.

Ahmed S, Al-Saigh S, Matthews J.

Mol Cancer Res. 2012 May;10(5):636-48. doi: 10.1158/1541-7786.MCR-11-0502.

19.

Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3).

Qi J, Huo L, Zhu YT, Zhu YJ.

J Biol Chem. 2014 Nov 7;289(45):31373-81. doi: 10.1074/jbc.M114.579839. Epub 2014 Sep 25.

20.

Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

Aronchik I, Bjeldanes LF, Firestone GL.

Cancer Res. 2010 Jun 15;70(12):4961-71. doi: 10.1158/0008-5472.CAN-09-3349. Epub 2010 Jun 8.

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