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Items: 1 to 20 of 91


Nek4 status differentially alters sensitivity to distinct microtubule poisons.

Doles J, Hemann MT.

Cancer Res. 2010 Feb 1;70(3):1033-41. doi: 10.1158/0008-5472.CAN-09-2113. Epub 2010 Jan 26.


NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana.

Motose H, Hamada T, Yoshimoto K, Murata T, Hasebe M, Watanabe Y, Hashimoto T, Sakai T, Takahashi T.

Plant J. 2011 Sep;67(6):993-1005. doi: 10.1111/j.1365-313X.2011.04652.x. Epub 2011 Jul 1.


Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: a novel synergistic therapeutic intervention.

Mitra M, Kandalam M, Sundaram CS, Verma RS, Maheswari UK, Swaminathan S, Krishnakumar S.

Invest Ophthalmol Vis Sci. 2011 Jul 23;52(8):5441-8. doi: 10.1167/iovs.10-6973.


NIMA-related kinases regulate directional cell growth and organ development through microtubule function in Arabidopsis thaliana.

Motose H, Takatani S, Ikeda T, Takahashi T.

Plant Signal Behav. 2012 Dec;7(12):1552-5. doi: 10.4161/psb.22412. Epub 2012 Oct 16.


Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.

Chen YC, Lu PH, Pan SL, Teng CM, Kuo SC, Lin TP, Ho YF, Huang YC, Guh JH.

Biochem Pharmacol. 2007 Jun 30;74(1):10-9. Epub 2007 Mar 24.


Microtubule-damaging agents enhance RASSF1A-induced cell death in lung cancer cell lines.

Whang YM, Park KH, Jung HY, Jo UH, Kim YH.

Cancer. 2009 Mar 15;115(6):1253-66. doi: 10.1002/cncr.24113.


Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine.

Rathinasamy K, Jindal B, Asthana J, Singh P, Balaji PV, Panda D.

BMC Cancer. 2010 May 19;10:213. doi: 10.1186/1471-2407-10-213.


An antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamics.

Rai A, Surolia A, Panda D.

PLoS One. 2012;7(8):e44311. doi: 10.1371/journal.pone.0044311. Epub 2012 Aug 31.


Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.

Wong VK, Chiu P, Chung SS, Chow LM, Zhao YZ, Yang BB, Ko BC.

Clin Cancer Res. 2005 Aug 15;11(16):6002-11.


Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin.

Gan PP, McCarroll JA, Po'uha ST, Kamath K, Jordan MA, Kavallaris M.

Mol Cancer Ther. 2010 May;9(5):1339-48. doi: 10.1158/1535-7163.MCT-09-0679. Epub 2010 May 4.


LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs.

Po'uha ST, Shum MS, Goebel A, Bernard O, Kavallaris M.

Oncogene. 2010 Jan 28;29(4):597-607. doi: 10.1038/onc.2009.367. Epub 2009 Nov 2.


Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non small cell lung cancer.

Gan PP, Pasquier E, Kavallaris M.

Cancer Res. 2007 Oct 1;67(19):9356-63.


Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents.

Dowling M, Voong KR, Kim M, Keutmann MK, Harris E, Kao GD.

Cancer Biol Ther. 2005 Feb;4(2):197-206. Epub 2005 Feb 8.


c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.

Chen J, Sun WL, Wasylyk B, Wang YP, Zheng H.

Anticancer Drugs. 2012 Jan;23(1):98-107. doi: 10.1097/CAD.0b013e32834bc978.


Overexpression of centrosomal protein Nlp confers breast carcinoma resistance to paclitaxel.

Zhao W, Song Y, Xu B, Zhan Q.

Cancer Biol Ther. 2012 Feb 1;13(3):156-63. doi: 10.4161/cbt.13.3.18697.


Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

ter Haar E, Kowalski RJ, Hamel E, Lin CM, Longley RE, Gunasekera SP, Rosenkranz HS, Day BW.

Biochemistry. 1996 Jan 9;35(1):243-50.


BRCA1 is regulated by Chk2 in response to spindle damage.

Chabalier-Taste C, Racca C, Dozier C, Larminat F.

Biochim Biophys Acta. 2008 Dec;1783(12):2223-33. doi: 10.1016/j.bbamcr.2008.08.006. Epub 2008 Aug 26.


Modulating microtubule stability enhances the cytotoxic response of cancer cells to Paclitaxel.

Ahmed AA, Wang X, Lu Z, Goldsmith J, Le XF, Grandjean G, Bartholomeusz G, Broom B, Bast RC Jr.

Cancer Res. 2011 Sep 1;71(17):5806-17. doi: 10.1158/0008-5472.CAN-11-0025. Epub 2011 Jul 20.


Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.

Hage-Sleiman R, Herveau S, Matera EL, Laurier JF, Dumontet C.

BMC Cancer. 2010 Apr 12;10:135. doi: 10.1186/1471-2407-10-135.


Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.

Xu W, Xi B, Wu J, An H, Zhu J, Abassi Y, Feinstein SC, Gaylord M, Geng B, Yan H, Fan W, Sui M, Wang X, Xu X.

Mol Cancer Ther. 2009 Dec;8(12):3318-30. doi: 10.1158/1535-7163.MCT-09-0548. Epub .

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