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Results: 1 to 20 of 113

1.

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2010 Mar 26;285(13):9919-31. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25.

PMID:
20100828
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.

Harikumar KG, Lam PC, Dong M, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2007 Nov 9;282(45):32834-43. Epub 2007 Sep 7.

PMID:
17827151
[PubMed - indexed for MEDLINE]
Free Article
4.

Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.

Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2011 Jul 8;286(27):23888-99. doi: 10.1074/jbc.M111.245969. Epub 2011 May 12.

PMID:
21566140
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2007 Aug;72(2):280-90. Epub 2007 May 2.

PMID:
17475809
[PubMed - indexed for MEDLINE]
Free Article
6.

Molecular approximation between residue 10 of secretin and its receptor demonstrated by photoaffinity labeling.

Dong M, Miller LJ.

Ann N Y Acad Sci. 2006 Jul;1070:243-7.

PMID:
16888174
[PubMed - indexed for MEDLINE]
7.
8.

Identification of two pairs of spatially approximated residues within the carboxyl terminus of secretin and its receptor.

Dong M, Asmann YW, Zang M, Pinon DI, Miller LJ.

J Biol Chem. 2000 Aug 25;275(34):26032-9.

PMID:
10859300
[PubMed - indexed for MEDLINE]
Free Article
9.

Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.

Dong M, Li Z, Pinon DI, Lybrand TP, Miller LJ.

J Biol Chem. 2004 Jan 23;279(4):2894-903. Epub 2003 Oct 30.

PMID:
14593094
[PubMed - indexed for MEDLINE]
Free Article
10.

Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor.

Dong M, Wang Y, Hadac EM, Pinon DI, Holicky E, Miller LJ.

J Biol Chem. 1999 Jul 2;274(27):19161-7.

PMID:
10383421
[PubMed - indexed for MEDLINE]
Free Article
11.

Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor.

Zang M, Dong M, Pinon DI, Ding XQ, Hadac EM, Li Z, Lybrand TP, Miller LJ.

Mol Pharmacol. 2003 May;63(5):993-1001. Erratum in: Mol Pharmacol. 2003 Ju;;64(1):193.

PMID:
12695527
[PubMed - indexed for MEDLINE]
Free Article
12.

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor.

Gao F, Harikumar KG, Dong M, Lam PC, Sexton PM, Christopoulos A, Bordner A, Abagyan R, Miller LJ.

Mol Pharmacol. 2009 Aug;76(2):264-74. doi: 10.1124/mol.109.055756. Epub 2009 May 8.

PMID:
19429716
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Dual contacts between peptide agonist ligands and the secretin receptor directly established by photoaffinity labeling.

Dong M, Wang Y, Miller LJ.

Ann N Y Acad Sci. 2000;921:381-6.

PMID:
11193860
[PubMed - indexed for MEDLINE]
14.

Differential spatial approximation between secretin and its receptor residues in active and inactive conformations demonstrated by photoaffinity labeling.

Dong M, Hosohata K, Pinon DI, Muthukumaraswamy N, Miller LJ.

Mol Endocrinol. 2006 Jul;20(7):1688-98. Epub 2006 Mar 2.

PMID:
16513792
[PubMed - indexed for MEDLINE]
15.

Development of a biologically active secretin analogue incorporating a radioiodinatable photolabile p-(4-hydroxybenzoyl)phenylalanine in position 10.

Dong M, Pinon DI, Miller LJ.

Regul Pept. 2002 Nov 15;109(1-3):181-7.

PMID:
12409231
[PubMed - indexed for MEDLINE]
16.

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.

Dong M, Te JA, Xu X, Wang J, Pinon DI, Storjohann L, Bordner AJ, Miller LJ.

Biochemistry. 2011 Sep 27;50(38):8181-92. doi: 10.1021/bi2008036. Epub 2011 Aug 30.

PMID:
21851058
[PubMed - indexed for MEDLINE]
Free PMC Article
17.
18.

Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.

Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2008 Aug;74(2):413-22. doi: 10.1124/mol.108.047209. Epub 2008 May 8.

PMID:
18467541
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.

Miller LJ, Dong M, Harikumar KG, Gao F.

Biochem Soc Trans. 2007 Aug;35(Pt 4):709-12. Review.

PMID:
17635130
[PubMed - indexed for MEDLINE]
20.

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints.

Dong M, Pinon DI, Bordner AJ, Miller LJ.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6040-4. doi: 10.1016/j.bmcl.2010.08.062. Epub 2010 Aug 15.

PMID:
20813522
[PubMed - indexed for MEDLINE]
Free PMC Article

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