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Results: 1 to 20 of 152

1.

Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines.

Doolan P, Meleady P, Barron N, Henry M, Gallagher R, Gammell P, Melville M, Sinacore M, McCarthy K, Leonard M, Charlebois T, Clynes M.

Biotechnol Bioeng. 2010 May 1;106(1):42-56. doi: 10.1002/bit.22670.

PMID:
20091739
[PubMed - indexed for MEDLINE]
2.

Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells.

Nissom PM, Sanny A, Kok YJ, Hiang YT, Chuah SH, Shing TK, Lee YY, Wong KT, Hu WS, Sim MY, Philp R.

Mol Biotechnol. 2006 Oct;34(2):125-40.

PMID:
17172658
[PubMed - indexed for MEDLINE]
3.

Proteomic profiling of a high-producing Chinese hamster ovary cell culture.

Carlage T, Hincapie M, Zang L, Lyubarskaya Y, Madden H, Mhatre R, Hancock WS.

Anal Chem. 2009 Sep 1;81(17):7357-62. doi: 10.1021/ac900792z.

PMID:
19663468
[PubMed - indexed for MEDLINE]
4.

Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Kumar N, Gammell P, Meleady P, Henry M, Clynes M.

BMC Biotechnol. 2008 Apr 22;8:42. doi: 10.1186/1472-6750-8-42.

PMID:
18430238
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

Gammell P, Barron N, Kumar N, Clynes M.

J Biotechnol. 2007 Jun 30;130(3):213-8. Epub 2007 Apr 29.

PMID:
17570552
[PubMed - indexed for MEDLINE]
6.

Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity.

Clarke C, Doolan P, Barron N, Meleady P, O'Sullivan F, Gammell P, Melville M, Leonard M, Clynes M.

J Biotechnol. 2011 Sep 20;155(3):350-9. doi: 10.1016/j.jbiotec.2011.07.011. Epub 2011 Jul 27.

PMID:
21801763
[PubMed - indexed for MEDLINE]
7.

Transcriptional profiling of phenotypically different Epo-Fc expressing CHO clones by cross-species microarray analysis.

Trummer E, Ernst W, Hesse F, Schriebl K, Lattenmayer C, Kunert R, Vorauer-Uhl K, Katinger H, Müller D.

Biotechnol J. 2008 Jul;3(7):924-37. doi: 10.1002/biot.200800038.

PMID:
18481264
[PubMed - indexed for MEDLINE]
8.

Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol.

Meleady P, Henry M, Gammell P, Doolan P, Sinacore M, Melville M, Francullo L, Leonard M, Charlebois T, Clynes M.

Proteomics. 2008 Jul;8(13):2611-24. doi: 10.1002/pmic.200700854.

PMID:
18546152
[PubMed - indexed for MEDLINE]
9.

Targeting early apoptotic genes in batch and fed-batch CHO cell cultures.

Wong DC, Wong KT, Nissom PM, Heng CK, Yap MG.

Biotechnol Bioeng. 2006 Oct 20;95(3):350-61.

PMID:
16894638
[PubMed - indexed for MEDLINE]
10.

Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment.

Yee JC, de Leon Gatti M, Philp RJ, Yap M, Hu WS.

Biotechnol Bioeng. 2008 Apr 1;99(5):1186-204.

PMID:
17929327
[PubMed - indexed for MEDLINE]
11.

Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates.

Kim JY, Kim YG, Han YK, Choi HS, Kim YH, Lee GM.

Appl Microbiol Biotechnol. 2011 Mar;89(6):1917-28. doi: 10.1007/s00253-011-3106-9. Epub 2011 Feb 1.

PMID:
21286710
[PubMed - indexed for MEDLINE]
12.

Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death.

Othumpangat S, Kashon M, Joseph P.

Mol Cell Biochem. 2005 Nov;279(1-2):123-31.

PMID:
16283521
[PubMed - indexed for MEDLINE]
13.

Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.

Doolan P, Melville M, Gammell P, Sinacore M, Meleady P, McCarthy K, Francullo L, Leonard M, Charlebois T, Clynes M.

Mol Biotechnol. 2008 Jul;39(3):187-99. doi: 10.1007/s12033-008-9039-6. Epub 2008 Feb 1.

PMID:
18240028
[PubMed - indexed for MEDLINE]
14.

Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate.

Clarke C, Henry M, Doolan P, Kelly S, Aherne S, Sanchez N, Kelly P, Kinsella P, Breen L, Madden SF, Zhang L, Leonard M, Clynes M, Meleady P, Barron N.

BMC Genomics. 2012 Nov 21;13:656. doi: 10.1186/1471-2164-13-656.

PMID:
23170974
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Elucidating the role of requiem in the growth and death of Chinese hamster ovary cells.

Lim Y, Seah VX, Mantalaris A, Yap MG, Wong DC.

Apoptosis. 2010 Apr;15(4):450-62. doi: 10.1007/s10495-009-0433-8.

PMID:
20012365
[PubMed - indexed for MEDLINE]
16.

Comparative transcriptional analysis of mouse hybridoma and recombinant Chinese hamster ovary cells undergoing butyrate treatment.

De Leon Gatti M, Wlaschin KF, Nissom PM, Yap M, Hu WS.

J Biosci Bioeng. 2007 Jan;103(1):82-91.

PMID:
17298905
[PubMed - indexed for MEDLINE]
Free Article
17.

Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture.

Zanghi JA, Fussenegger M, Bailey JE.

Biotechnol Bioeng. 1999 Jul 5;64(1):108-19.

PMID:
10397845
[PubMed - indexed for MEDLINE]
18.

Microarray analysis identifies differentially expressed genes induced by human papillomavirus type 18 E6 silencing RNA.

Min W, Wen-li M, Zhao-hui S, Ling L, Bao Z, Wen-ling Z.

Int J Gynecol Cancer. 2009 May;19(4):547-63. doi: 10.1111/IGC.0b013e3181a44c68.

PMID:
19509549
[PubMed - indexed for MEDLINE]
19.

Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells.

Meleady P, Gallagher M, Clarke C, Henry M, Sanchez N, Barron N, Clynes M.

J Biotechnol. 2012 Aug 31;160(3-4):251-62. doi: 10.1016/j.jbiotec.2012.03.002. Epub 2012 Mar 15.

PMID:
22445466
[PubMed - indexed for MEDLINE]
20.

Differential display identifies genes in Chinese hamster ovary cells sensitive to elevated ammonium.

Chen P, Harcum SW.

Appl Biochem Biotechnol. 2007 May-Jun;141(2-3):349-59.

PMID:
18025561
[PubMed - indexed for MEDLINE]

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