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20089808,17645739,17390080,20178133,15476200,16765938,15389584,18679798,16888805,16126838,20100175,16423197,17311279,18252806,15982617,9648711,10101031,15173070,18574003,12507586,20026325,12626640,19417026,15569826,17446059,19175673,12145097,18950863,20436222,19782127,22179411,22427564,21470077,15231489,21764456,19793766,24552656,11564882,20411335,20533305,17690186,15784648,21471446,16452236,15485842,21059338,17724435,28238855,16461893,9605580,21984126,23851002,22464096,21570457,21400616,15550066,20137277,21993883,17936667,15769552,20132813,15345683,18603327,21600652,24842488,16834785,15741731,20846475,21068409,25069417,19552715,23871663,20200229,16792687,20019363,21454676,21922126,19739429,15125785,16103072,16038800,9927384,10706714,20450637,18187551,20351138,30078834,15319367,23619266,20800791,12444149,17403137,28299397,20381601,21821055,25816341,27060290,21745629,21924184,22200679,22014408,16971406,21777978,20816994,20302854,20403460,21396905,9786861,15836614,21471444,11181433,15590669,23416140,18508759,12761358,19648110,26512830,23707387,22433003,15860795,24844442,25950450,26471700,25724669,10445612,22053946,22161830,14530261,20868379,22138297,25615285,16549373,16740161,20307528,16300728,20008283,16003000,23588209,9516459,21750859,22342441,20417710,21447443,21956667,21112343,19843478,21453678,12727980,16000872,26527061,20727407,23042199,16881863,21285293,23030431,10619832,23612802,17114490,23076500,18945810,25843005,23183108,12153684,16293708,25914463,23714383,28096466,16552807,18314542,15996190,21771211,17322004,24032470,22116077,11723054,11137629,17637225,11387337,24706000,15240896,22381257,24589569,16202406,22322153,24403530,20589745,18457971,24861519,26988982,21094639,17443309,19181383,23139385,23679818,25548490,21453744,20538267,20465215,27548147,25660969,16618780,15886520,21166654,21302967,20093631,19427347,27173611,19166300,24126911,15321787,20307249,25996641,22865045,22446810,16887914,20860659,18003751,30897501,17636038,20478268,22506718,23056550,20846183,20418099,23392662,32240312,20525168,26637635,18586382,22545125,17012372,20121928,20642578,15640643,17085539,17334237,21610141,21224048,19267548,26399197,20712346,19235539,22316665,10226066,20650996,25599677,16380513,11294978,23624146,23500159,18723442,26655749,30004580,22437006,20113784,16123165,24253595,22983538,10329406,22183614,29926065,24380287,17786963,15668322,25301363,20438701,30115376,28054591,32998359,23683276,20920579,21745554,23220022,21926646,23825193,22100391,20646342,22391335,25435485,17251521,22037550,17761948,17460151,15845864,23425072,20803086,12901852,12915102,15118344,18922786,21642589,25778306,24121109,19286927,22867423,20732391,19864641,21484436,9726973,24374966,9790925,11046054,11257445,22711061,22294037,29245047,24746746,17057737,23498167,28657665,17438131,20005940,22431089,11692108,22313544,17085321,22575517,27097228,16002953,24070709,25157456,22888172,25389768,15867363,25047843,22687715,18845168,15196213,26799482,27744428,21959016,26722604,22924482,22198289,18599066,17720847,21911040,19684251,12098600,23226236,20017901,26123523,19076312,17404316,22898817,29317435,24686178,19209241,28404919,12161102,15890751,21547253,21190604,26487798,36803959,27875656,23022409,20043958,23442671,15677771,17507666,24104198,26574643,12732207,26120912,22385244,23638878,23285690,19248755,20713550,28154014,26288134,28550735,10762076,12840156,21862584,26825339,36625590,16698271,22268118,25108419,23109722,36110124,26280733,24894820,18314537,28629997,20207050,28899709,23584919,15668181,16516846,24112275,21924259,19893732,19654329,16085674,10988133,25936351,22407817,19653348,22951730,28204809,22627361,18288129,28618937,11398077,34836195,30724633,22197701,19627252,27454161,20070836,31256425,29794990,18653246,16595469,17379505,24133591,23623867,16790784,20042643,21803118,15975822,25695486,34985993,16948396,17208222,35409238,30935901,17932218,19929574,18184679,22573375,18938228,21085614,22493490,22865050,15888346,19890037,12889600,22621989,27053523,29287762,18367666,24099766,19069644,25013817,30518116,20851927,21682888,28195157,32016419,25312648,19249598,16373669,29115603,29054824,17668318,26689981,26986625,15796912,34039638,17386088,15383152,17892396,19807155,30502647,16716121,17848570,19140872,20494134,30333178,24727856,25409926,17014329,24238522,18641354,18979912,22540262,15748812,34205482,28869889,23449457,27188729,17151092,20378346,18270299,30558829,25577341,22582160,30269025,21507199,24418482,30648905,22357202,17404307,19004925,34818666,20226236,28457938,11884401,23549267,20226009,24632454,29141025,19570915,21199832,16204058,34774714,20173047,25685800,35580782,29226622,32315671,29635194,15689616,14561087,18331592,16433908,20547488,29619028,30136021,16988192,18097057,26849227,19343203,28988112,28955885,33524056,31900478,14644930,22729740,20621720,17893134,16296325,24692548,17906919,26452008,9636165,25366993,26974691,17717636,23446663,28039016,20404768,21801798,27599524,30203485,22905713,26546680,25287866,32374464,34601745,28388885,23849041,2811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Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells.

Turpeinen T, Nieminen R, Moilanen E, Korhonen R. Turpeinen T, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):310-8. doi: 10.1124/jpet.109.157438. Epub 2010 Jan 20. J Pharmacol Exp Ther. 2010. PMID: 20089808

Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells.

Jang BC, Lim KJ, Suh MH, Park JG, Suh SI. Jang BC, et al. FEMS Immunol Med Microbiol. 2007 Oct;51(1):171-84. doi: 10.1111/j.1574-695X.2007.00293.x. Epub 2007 Jul 23. FEMS Immunol Med Microbiol. 2007. PMID: 17645739 Free article.

Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.

Jang BC, Lim KJ, Choi IH, Suh MH, Park JG, Mun KC, Bae JH, Shin DH, Suh SI. Jang BC, et al. Int J Mol Med. 2007 May;19(5):757-63. Int J Mol Med. 2007. PMID: 17390080

Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs.

Nieminen R, Korhonen R, Moilanen T, Clark AR, Moilanen E. Nieminen R, et al. Arthritis Rheum. 2010 Jun;62(6):1650-9. doi: 10.1002/art.27409. Arthritis Rheum. 2010. PMID: 20178133 Free article.

Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids.

Toh ML, Yang Y, Leech M, Santos L, Morand EF. Toh ML, et al. Arthritis Rheum. 2004 Oct;50(10):3118-28. doi: 10.1002/art.20580. Arthritis Rheum. 2004. PMID: 15476200 Free article.

Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells.

Chen TH, Kao YC, Chen BC, Chen CH, Chan P, Lee HM. Chen TH, et al. Eur J Pharmacol. 2006 Jul 17;541(3):138-46. doi: 10.1016/j.ejphar.2006.05.002. Eur J Pharmacol. 2006. PMID: 16765938

Involvement of p42/p44 MAPK, JNK, and NF-kappaB in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells.

Lin FS, Lin CC, Chien CS, Luo SF, Yang CM. Lin FS, et al. J Cell Physiol. 2005 Feb;202(2):464-73. doi: 10.1002/jcp.20142. J Cell Physiol. 2005. PMID: 15389584

Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression.

Serini S, Trombino S, Oliva F, Piccioni E, Monego G, Resci F, Boninsegna A, Picci N, Ranelletti FO, Calviello G. Serini S, et al. Apoptosis. 2008 Sep;13(9):1172-83. doi: 10.1007/s10495-008-0246-1. Apoptosis. 2008. PMID: 18679798

Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases.

Bauer I, Al Sarraj J, Vinson C, Larsen R, Thiel G. Bauer I, et al. J Cell Biochem. 2007 Jan 1;100(1):242-55. doi: 10.1002/jcb.21075. J Cell Biochem. 2007. PMID: 16888805

Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor-kappaB, p38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase activation.

Kwak HJ, Song JS, Heo JY, Yang SD, Nam JY, Cheon HG. Kwak HJ, et al. J Pharmacol Exp Ther. 2005 Dec;315(3):1188-95. doi: 10.1124/jpet.105.092056. Epub 2005 Aug 26. J Pharmacol Exp Ther. 2005. PMID: 16126838

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