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IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms.

De Bruyne E, Bos TJ, Schuit F, Van Valckenborgh E, Menu E, Thorrez L, Atadja P, Jernberg-Wiklund H, Vanderkerken K.

Blood. 2010 Mar 25;115(12):2430-40. doi: 10.1182/blood-2009-07-232801. Epub 2010 Jan 19.


Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.

Möller C, Alfredsson J, Engström M, Wootz H, Xiang Z, Lennartsson J, Jönsson JI, Nilsson G.

Blood. 2005 Aug 15;106(4):1330-6. Epub 2005 Apr 26.


Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim.

Paschos K, Smith P, Anderton E, Middeldorp JM, White RE, Allday MJ.

PLoS Pathog. 2009 Jun;5(6):e1000492. doi: 10.1371/journal.ppat.1000492. Epub 2009 Jun 26.


Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis.

Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ.

J Biol Chem. 2007 Sep 14;282(37):27141-54. Epub 2007 Jul 11.


FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells.

Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ.

Cell Death Differ. 2007 Mar;14(3):534-47. Epub 2006 Aug 4.


Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex.

Gomez-Bougie P, Oliver L, Le Gouill S, Bataille R, Amiot M.

Oncogene. 2005 Dec 1;24(54):8076-9.


FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.

Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW.

J Biol Chem. 2003 Dec 12;278(50):49795-805. Epub 2003 Oct 3.


FOXO3a: a novel player in thyroid carcinogenesis?

Karger S, Weidinger C, Krause K, Sheu SY, Aigner T, Gimm O, Schmid KW, Dralle H, Fuhrer D.

Endocr Relat Cancer. 2009 Mar;16(1):189-99. doi: 10.1677/ERC-07-0283. Epub 2008 Oct 9.


Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

Essafi A, Fernández de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, Medema RH, Lam EW.

Oncogene. 2005 Mar 31;24(14):2317-29.


RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells.

Yamamura Y, Lee WL, Inoue K, Ida H, Ito Y.

J Biol Chem. 2006 Feb 24;281(8):5267-76. Epub 2005 Dec 22.


EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities.

Quadros MR, Connelly S, Kari C, Abrams MT, Wickstrom E, Rodeck U.

Cancer Biol Ther. 2006 May;5(5):498-504. Epub 2006 May 6.


Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.

Piazza R, Magistroni V, Mogavero A, Andreoni F, Ambrogio C, Chiarle R, Mologni L, Bachmann PS, Lock RB, Collini P, Pelosi G, Gambacorti-Passerini C.

Neoplasia. 2013 May;15(5):511-22.


Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation.

Borensztajn KS, Bijlsma MF, Groot AP, Brüggemann LW, Versteeg HH, Reitsma PH, Peppelenbosch MP, Spek CA.

Exp Cell Res. 2007 Jul 15;313(12):2622-33. Epub 2007 Apr 19.


The imbalance between Survivin and Bim mediates tumour growth and correlates with poor survival in patients with multiple myeloma.

Romagnoli M, Séveno C, Wuillème-Toumi S, Amiot M, Bataille R, Minvielle S, Barillé-Nion S.

Br J Haematol. 2009 Apr;145(2):180-9. doi: 10.1111/j.1365-2141.2009.07608.x. Epub 2009 Mar 2.


Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P.

Oncogene. 2003 Oct 2;22(43):6785-93.


18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.

Sharma G, Kar S, Palit S, Das PK.

J Cell Physiol. 2012 May;227(5):1923-31. doi: 10.1002/jcp.22920.

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