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Results: 1 to 20 of 137

1.

Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes.

Rana R, Chen Y, Ferguson SS, Kissling GE, Surapureddi S, Goldstein JA.

Drug Metab Dispos. 2010 Apr;38(4):591-9. doi: 10.1124/dmd.109.030387. Epub 2010 Jan 19.

PMID:
20086032
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Induction of CYP2C genes in human hepatocytes in primary culture.

Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L, Daujat M, Waechter F, Fabre JM, Carrère N, Maurel P.

Drug Metab Dispos. 2001 Mar;29(3):242-51.

PMID:
11181490
[PubMed - indexed for MEDLINE]
Free Article
4.

Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.

Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA.

Mol Pharmacol. 2005 Sep;68(3):747-57. Epub 2005 Jun 2.

PMID:
15933212
[PubMed - indexed for MEDLINE]
Free Article
5.

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes.

Raucy JL, Mueller L, Duan K, Allen SW, Strom S, Lasker JM.

J Pharmacol Exp Ther. 2002 Aug;302(2):475-82.

PMID:
12130704
[PubMed - indexed for MEDLINE]
Free Article
6.

The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.

Chen Y, Kissling G, Negishi M, Goldstein JA.

J Pharmacol Exp Ther. 2005 Sep;314(3):1125-33. Epub 2005 May 26.

PMID:
15919766
[PubMed - indexed for MEDLINE]
Free Article
7.

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA.

Kamiyama Y, Matsubara T, Yoshinari K, Nagata K, Kamimura H, Yamazoe Y.

Drug Metab Pharmacokinet. 2007 Aug;22(4):287-98.

PMID:
17827783
[PubMed - indexed for MEDLINE]
Free Article
8.

Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.

Fang HL, Strom SC, Ellis E, Duanmu Z, Fu J, Duniec-Dmuchowski Z, Falany CN, Falany JL, Kocarek TA, Runge-Morris M.

J Pharmacol Exp Ther. 2007 Nov;323(2):586-98. Epub 2007 Aug 8.

PMID:
17687072
[PubMed - indexed for MEDLINE]
Free Article
9.

Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene.

Chen Y, Coulter S, Jetten AM, Goldstein JA.

J Pharmacol Exp Ther. 2009 Apr;329(1):192-201. doi: 10.1124/jpet.108.148916. Epub 2009 Jan 22.

PMID:
19164466
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.

PMID:
17392393
[PubMed - indexed for MEDLINE]
Free Article
11.

Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

Bort R, Gómez-Lechón MJ, Castell JV, Jover R.

Arch Biochem Biophys. 2004 Jun 1;426(1):63-72.

PMID:
15130783
[PubMed - indexed for MEDLINE]
12.
13.

Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.

Chen Y, Ferguson SS, Negishi M, Goldstein JA.

J Pharmacol Exp Ther. 2004 Feb;308(2):495-501. Epub 2003 Nov 4.

PMID:
14600250
[PubMed - indexed for MEDLINE]
Free Article
14.

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.

Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA.

Mol Pharmacol. 2002 Sep;62(3):737-46.

PMID:
12181452
[PubMed - indexed for MEDLINE]
Free Article
15.

Differential expression and function of CYP2C isoforms in human intestine and liver.

Läpple F, von Richter O, Fromm MF, Richter T, Thon KP, Wisser H, Griese EU, Eichelbaum M, Kivistö KT.

Pharmacogenetics. 2003 Sep;13(9):565-75.

PMID:
12972955
[PubMed - indexed for MEDLINE]
16.

Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver.

Kawashima S, Kobayashi K, Takama K, Higuchi T, Furihata T, Hosokawa M, Chiba K.

Drug Metab Dispos. 2006 Jun;34(6):1012-8. Epub 2006 Mar 15.

PMID:
16540586
[PubMed - indexed for MEDLINE]
Free Article
17.

The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.

Goodwin B, Hodgson E, Liddle C.

Mol Pharmacol. 1999 Dec;56(6):1329-39.

PMID:
10570062
[PubMed - indexed for MEDLINE]
Free Article
18.

Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig.

Nannelli A, Chirulli V, Longo V, Gervasi PG.

Toxicology. 2008 Oct 30;252(1-3):105-12. doi: 10.1016/j.tox.2008.08.004. Epub 2008 Aug 22.

PMID:
18786598
[PubMed - indexed for MEDLINE]
19.

Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.

Kojima K, Nagata K, Matsubara T, Yamazoe Y.

Drug Metab Pharmacokinet. 2007 Aug;22(4):276-86.

PMID:
17827782
[PubMed - indexed for MEDLINE]
Free Article
20.

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.

Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB.

Nat Med. 2003 Feb;9(2):220-4. Epub 2003 Jan 6.

PMID:
12514743
[PubMed - indexed for MEDLINE]

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