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Items: 1 to 20 of 145


Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.

Xie Z, Su W, Guo Z, Pang H, Post SR, Gong MC.

Cardiovasc Res. 2006 Feb 1;69(2):491-501. Epub 2005 Dec 5.


Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.

Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T.

Circ Res. 2003 Mar 7;92(4):411-8. Epub 2003 Feb 6.


Increased basal phosphorylation of detrusor smooth muscle myosin in alloxan-induced diabetic rabbit is mediated by upregulation of Rho-kinase beta and CPI-17.

Chang S, Hypolite JA, DiSanto ME, Changolkar A, Wein AJ, Chacko S.

Am J Physiol Renal Physiol. 2006 Mar;290(3):F650-6. Epub 2005 Oct 4.


Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta.

Hu W, Mahavadi S, Li F, Murthy KS.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1991-2000. Epub 2007 Oct 24.


RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle cells.

Pang H, Guo Z, Su W, Xie Z, Eto M, Gong MC.

Am J Physiol Cell Physiol. 2005 Aug;289(2):C352-60. Epub 2005 Apr 6.


A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.

Pagiatakis C, Gordon JW, Ehyai S, McDermott JC.

J Biol Chem. 2012 Mar 9;287(11):8361-70. doi: 10.1074/jbc.M111.286203. Epub 2012 Jan 23.


Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation.

Liu S, Xie Z, Zhao Q, Pang H, Turk J, Calderon L, Su W, Zhao G, Xu H, Gong MC, Guo Z.

J Biol Chem. 2012 Jul 13;287(29):24739-53. doi: 10.1074/jbc.M112.340216. Epub 2012 May 25.


Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy.

Boopathi E, Gomes C, Zderic SA, Malkowicz B, Chakrabarti R, Patel DP, Wein AJ, Chacko S.

Am J Physiol Cell Physiol. 2014 Sep 15;307(6):C542-53. doi: 10.1152/ajpcell.00033.2014. Epub 2014 Jul 16.


A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate.

Baek I, Jeon SB, Kim J, Seok YM, Song MJ, Chae SC, Jun JE, Park WH, Kim IK.

Clin Exp Pharmacol Physiol. 2009 Mar;36(3):256-61. doi: 10.1111/j.1440-1681.2008.05045.x. Epub 2008 Oct 8.


Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction.

Sakurada S, Takuwa N, Sugimoto N, Wang Y, Seto M, Sasaki Y, Takuwa Y.

Circ Res. 2003 Sep 19;93(6):548-56. Epub 2003 Aug 14.


Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2.

Soliman H, Gador A, Lu YH, Lin G, Bankar G, MacLeod KM.

Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H989-H1000. doi: 10.1152/ajpheart.00416.2012. Epub 2012 Aug 3.


Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.

Dietrich HH, Abendschein DR, Moon SH, Nayeb-Hashemi N, Mancuso DJ, Jenkins CM, Kaltenbronn KM, Blumer KJ, Turk J, Gross RW.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2208-20. doi: 10.1152/ajpheart.00839.2009. Epub 2010 Apr 9.


The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.

Pattabiraman PP, Lih FB, Tomer KB, Rao PV.

Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C979-91. doi: 10.1152/ajpcell.00396.2011. Epub 2012 Jan 11.


Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.

Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL.

J Biol Chem. 2001 Aug 3;276(31):29072-8. Epub 2001 Jun 7.


Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway.

Sun J, Yang T, Wang P, Ma S, Zhu Z, Pu Y, Li L, Zhao Y, Xiong S, Liu D, Zhu Z.

Hypertension. 2014 Jun;63(6):1354-63. doi: 10.1161/HYPERTENSIONAHA.113.02573. Epub 2014 Mar 17.


Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.

Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35. doi: 10.1152/ajpgi.00388.2012. Epub 2012 Dec 28.

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