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Results: 1 to 20 of 89

1.

Synthesis and structure-activity relationship of substitutions at the C-1 position of Delta9-tetrahydrocannabinol.

Burdick D, DeOrazio R, Guzzo P, Habershaw A, Helle M, Paul B, Wolf M.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1424-6. doi: 10.1016/j.bmcl.2009.12.092. Epub 2010 Jan 4.

PMID:
20079638
[PubMed - indexed for MEDLINE]
2.

Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.

Reggio PH, Wang T, Brown AE, Fleming DN, Seltzman HH, Griffin G, Pertwee RG, Compton DR, Abood ME, Martin BR.

J Med Chem. 1997 Sep 26;40(20):3312-8.

PMID:
9379452
[PubMed - indexed for MEDLINE]
3.

3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.

Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR.

Bioorg Med Chem. 1999 Dec;7(12):2905-14.

PMID:
10658595
[PubMed - indexed for MEDLINE]
4.

(-)-Delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase.

Bayewitch M, Rhee MH, Avidor-Reiss T, Breuer A, Mechoulam R, Vogel Z.

J Biol Chem. 1996 Apr 26;271(17):9902-5.

PMID:
8626625
[PubMed - indexed for MEDLINE]
Free Article
5.

Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.

Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A.

J Med Chem. 1998 Mar 26;41(7):1195-200.

PMID:
9544219
[PubMed - indexed for MEDLINE]
6.

Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol.

Singer M, Ryan WJ, Saha B, Martin BR, Razdan RK.

J Med Chem. 1998 Oct 22;41(22):4400-7.

PMID:
9784115
[PubMed - indexed for MEDLINE]
7.

Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors.

Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG.

Br J Pharmacol. 1999 Oct;128(3):735-43.

PMID:
10516656
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions.

Romero J, Garcia-Palomero E, Castro JG, Garcia-Gil L, Ramos JA, Fernandez-Ruiz JJ.

Brain Res Mol Brain Res. 1997 Jun;46(1-2):100-8.

PMID:
9191083
[PubMed - indexed for MEDLINE]
9.

Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.

Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2119-24.

PMID:
10465529
[PubMed - indexed for MEDLINE]
10.

Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs.

Krishnamurthy M, Gurley S, Moore BM 2nd.

Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. doi: 10.1016/j.bmc.2008.05.034. Epub 2008 May 20.

PMID:
18524604
[PubMed - indexed for MEDLINE]
11.

Adamantyl cannabinoids: a novel class of cannabinergic ligands.

Lu D, Meng Z, Thakur GA, Fan P, Steed J, Tartal CL, Hurst DP, Reggio PH, Deschamps JR, Parrish DA, George C, Järbe TU, Lamb RJ, Makriyannis A.

J Med Chem. 2005 Jul 14;48(14):4576-85.

PMID:
15999995
[PubMed - indexed for MEDLINE]
12.

1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor.

Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR.

Bioorg Med Chem. 2002 Dec;10(12):4119-29.

PMID:
12413866
[PubMed - indexed for MEDLINE]
13.

Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats.

Garcia-Gil L, de Miguel R, Romero J, Perez A, Ramos JA, Fernández-Ruiz JJ.

Neurotoxicol Teratol. 1999 May-Jun;21(3):277-83.

PMID:
10386831
[PubMed - indexed for MEDLINE]
14.

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.

Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5780-5.

PMID:
10318961
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.

Fernández-Ruiz JJ, Muñoz RM, Romero J, Villanua MA, Makriyannis A, Ramos JA.

Biochem Pharmacol. 1997 Jun 15;53(12):1919-27.

PMID:
9256167
[PubMed - indexed for MEDLINE]
16.

Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.

Papahatjis DP, Nikas SP, Andreou T, Makriyannis A.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3583-6.

PMID:
12443781
[PubMed - indexed for MEDLINE]
17.

Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to delta9-tetrahydrocannabinol.

Romero J, Berrendero F, Manzanares J, Pérez A, Corchero J, Fuentes JA, Fernández-Ruiz JJ, Ramos JA.

Synapse. 1998 Nov;30(3):298-308.

PMID:
9776133
[PubMed - indexed for MEDLINE]
18.

Synthesis and pharmacology of the isomeric methylheptyl-delta8-tetrahydrocannabinols.

Huffman JW, Liddle J, Duncan SG Jr, Yu S, Martin BR, Wiley JL.

Bioorg Med Chem. 1998 Dec;6(12):2383-96.

PMID:
9925296
[PubMed - indexed for MEDLINE]
19.

QSAR analysis of Delta(8)-THC analogues: relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency.

Keimowitz AR, Martin BR, Razdan RK, Crocker PJ, Mascarella SW, Thomas BF.

J Med Chem. 2000 Jan 13;43(1):59-70.

PMID:
10633038
[PubMed - indexed for MEDLINE]
20.

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