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PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.

Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN.

Curr Biol. 2008 Jul 22;18(14):1034-43. doi: 10.1016/j.cub.2008.06.068.


Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis.

Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN.

J Cell Biol. 2010 Jul 26;190(2):233-45. doi: 10.1083/jcb.201001129.


Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium.

Kamimura Y, Tang M, Devreotes P.

Methods Mol Biol. 2009;571:255-70. doi: 10.1007/978-1-60761-198-1_17.


TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.

Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR 3rd, Parent CA, Firtel RA.

Mol Biol Cell. 2005 Oct;16(10):4572-83. Epub 2005 Aug 3.


Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum.

Zhang P, Wang Y, Sesaki H, Iijima M.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11829-34. doi: 10.1073/pnas.1006153107. Epub 2010 Jun 14.


A cell number counting factor regulates Akt/protein kinase B to regulate Dictyostelium discoideum group size.

Gao T, Knecht D, Tang L, Hatton RD, Gomer RH.

Eukaryot Cell. 2004 Oct;3(5):1176-84.


Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.

Cell Signal. 2007 Dec;19(12):2444-57. Epub 2007 Aug 3.


Protein kinase B gene homologue pkbR1 performs one of its roles at first finger stage of Dictyostelium.

Ochiai H, Takeda K, Fukuzawa M, Kato A, Takiya S, Ohmachi T.

Eukaryot Cell. 2011 Apr;10(4):512-20. doi: 10.1128/EC.00200-10. Epub 2011 Feb 18.


Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.

Egawa K, Maegawa H, Shi K, Nakamura T, Obata T, Yoshizaki T, Morino K, Shimizu S, Nishio Y, Suzuki E, Kashiwagi A.

J Biol Chem. 2002 Oct 11;277(41):38863-9. Epub 2002 Jul 29.


Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.

Anderson KE, Coadwell J, Stephens LR, Hawkins PT.

Curr Biol. 1998 Jun 4;8(12):684-91.


Tortoise, a novel mitochondrial protein, is required for directional responses of Dictyostelium in chemotactic gradients.

van Es S, Wessels D, Soll DR, Borleis J, Devreotes PN.

J Cell Biol. 2001 Feb 5;152(3):621-32.


Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.

Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes P.

Mol Biol Cell. 2011 Feb 15;22(4):437-47. doi: 10.1091/mbc.E10-06-0522. Epub 2010 Dec 17.


Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT.

Science. 1998 Jan 30;279(5351):710-4.


Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.

Zurashvili T, Cordón-Barris L, Ruiz-Babot G, Zhou X, Lizcano JM, Gómez N, Giménez-Llort L, Bayascas JR.

Mol Cell Biol. 2013 Mar;33(5):1027-40. doi: 10.1128/MCB.01052-12. Epub 2012 Dec 28. Erratum in: Mol Cell Biol. 2016 Jun 15;36(12):1818.

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