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Items: 1 to 20 of 680

1.

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.

Venieratos PD, Drossopoulou GI, Kapodistria KD, Tsilibary EC, Kitsiou PV.

Cell Signal. 2010 May;22(5):791-800. doi: 10.1016/j.cellsig.2010.01.003. Epub 2010 Jan 11.

PMID:
20067833
2.

Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells.

Hou R, Zhang J, Yin T, Cao H, Zhang N, Li X, Wang L, Xing Y, Li D, Ji Q.

Apoptosis. 2010 Aug;15(8):877-86. doi: 10.1007/s10495-010-0510-z.

PMID:
20464496
3.

The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells.

Emanuelli B, Glondu M, Filloux C, Peraldi P, Van Obberghen E.

Diabetes. 2004 Dec;53 Suppl 3:S97-S103.

4.

Insulin receptor substrate-1 and -2 mediate resistance to glucose-induced caspase-3 activation in human neuroblastoma cells.

Stöhr O, Hahn J, Moll L, Leeser U, Freude S, Bernard C, Schilbach K, Markl A, Udelhoven M, Krone W, Schubert M.

Biochim Biophys Acta. 2011 May;1812(5):573-80. doi: 10.1016/j.bbadis.2011.02.006. Epub 2011 Feb 24.

5.

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells.

Jacobsen ML, Rønn SG, Bruun C, Larsen CM, Eizirik DL, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2009 Feb;52(2):281-8. doi: 10.1007/s00125-008-1199-1. Epub 2008 Nov 11.

PMID:
19002429
6.

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2004 Nov;47(11):1998-2011. Epub 2004 Dec 2.

PMID:
15578154
7.

Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.

Kaminski A, Welters HJ, Kaminski ER, Morgan NG.

Biosci Rep. 2009 Dec 15;30(3):169-75. doi: 10.1042/BSR20090021.

PMID:
19531027
9.

Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.

D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G.

FASEB J. 2004 Jun;18(9):959-61. Epub 2004 Apr 1.

10.

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. doi: 10.2337/db07-1469. Epub 2008 Feb 14.

11.

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.

Mol Cell Biol. 2009 Jun;29(11):3219-28. doi: 10.1128/MCB.01489-08. Epub 2009 Mar 9.

12.

Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.

Hartman ME, O'Connor JC, Godbout JP, Minor KD, Mazzocco VR, Freund GG.

J Biol Chem. 2004 Jul 2;279(27):28045-50. Epub 2004 Apr 27.

13.

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA.

J Biol Chem. 2003 Apr 18;278(16):13740-6. Epub 2003 Jan 30.

14.

IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line.

Petersen LG, Størling J, Heding P, Li S, Berezin V, Saldeen J, Billestrup N, Bock E, Mandrup-Poulsen T.

Diabetologia. 2006 Aug;49(8):1864-75. Epub 2006 May 23.

PMID:
16718462
15.

Calreticulin regulates insulin receptor expression and its downstream PI3 Kinase/Akt signalling pathway.

Jalali S, Aghasi M, Yeganeh B, Mesaeli N.

Biochim Biophys Acta. 2008 Dec;1783(12):2344-51. doi: 10.1016/j.bbamcr.2008.08.014. Epub 2008 Sep 17.

16.

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.

Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED.

J Biol Chem. 2006 Mar 17;281(11):7060-7. Epub 2006 Jan 17.

17.

Radix asari extract protects pancreatic beta cells against cytokine-induced toxicity: implication of the NF-kappaB-iNOS signaling cascade.

Song MY, Kim KA, Lee SY, Kim EK, Lv N, Lee JH, Park JW, Ryu DG, Kwon KB, Park BH.

Int J Mol Med. 2007 Nov;20(5):769-75.

PMID:
17912472
19.

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

Størling J, Binzer J, Andersson AK, Züllig RA, Tonnesen M, Lehmann R, Spinas GA, Sandler S, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2005 Oct;48(10):2039-50. Epub 2005 Aug 25.

PMID:
16132952
20.

Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death.

Schrader J, Rennekamp W, Niebergall U, Schoppet M, Jahr H, Brendel MD, Hörsch D, Hofbauer LC.

Diabetologia. 2007 Jun;50(6):1243-7. Epub 2007 Apr 19.

PMID:
17443309
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