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Items: 1 to 20 of 168


CtIP links DNA double-strand break sensing to resection.

You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T.

Mol Cell. 2009 Dec 25;36(6):954-69. doi: 10.1016/j.molcel.2009.12.002.


The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.

Wang H, Shi LZ, Wong CC, Han X, Hwang PY, Truong LN, Zhu Q, Shao Z, Chen DJ, Berns MW, Yates JR 3rd, Chen L, Wu X.

PLoS Genet. 2013;9(2):e1003277. doi: 10.1371/journal.pgen.1003277. Epub 2013 Feb 28.


CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts.

Ramírez-Lugo JS, Yoo HY, Yoon SJ, Dunphy WG.

Cell Cycle. 2011 Feb 1;10(3):469-80. Epub 2011 Feb 1.


Human CtIP promotes DNA end resection.

Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP.

Nature. 2007 Nov 22;450(7169):509-14. Epub 2007 Oct 28.


Activation of DSB processing requires phosphorylation of CtIP by ATR.

Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J.

Mol Cell. 2013 Feb 21;49(4):657-67. doi: 10.1016/j.molcel.2012.11.020. Epub 2012 Dec 27.


ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response.

Martin NT, Nakamura K, Davies R, Nahas SA, Brown C, Tunuguntla R, Gatti RA, Hu H.

PLoS Genet. 2013 May;9(5):e1003505. doi: 10.1371/journal.pgen.1003505. Epub 2013 May 16.


Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

Chen L, Nievera CJ, Lee AY, Wu X.

J Biol Chem. 2008 Mar 21;283(12):7713-20. doi: 10.1074/jbc.M710245200. Epub 2008 Jan 2.


DNA damage signaling in response to double-strand breaks during mitosis.

Giunta S, Belotserkovskaya R, Jackson SP.

J Cell Biol. 2010 Jul 26;190(2):197-207. doi: 10.1083/jcb.200911156.


Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

Williams RS, Williams JS, Tainer JA.

Biochem Cell Biol. 2007 Aug;85(4):509-20. Review.


PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.

Di Virgilio M, Ying CY, Gautier J.

DNA Repair (Amst). 2009 Nov 2;8(11):1311-20. doi: 10.1016/j.dnarep.2009.07.006. Epub 2009 Aug 25.


Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.

Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J.

J Cell Biol. 2011 Sep 5;194(5):705-20. doi: 10.1083/jcb.201103103.


Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.

Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V.

EMBO J. 2008 Jul 23;27(14):1953-62. doi: 10.1038/emboj.2008.128. Epub 2008 Jul 3.


Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

J Biol Chem. 2007 Jun 15;282(24):17501-6. Epub 2007 Apr 19.


N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.

Yuan J, Chen J.

J Biol Chem. 2009 Nov 13;284(46):31746-52. doi: 10.1074/jbc.M109.023424. Epub 2009 Sep 16.


CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.

Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, Berns MW, Chen DJ, Wu X.

J Biol Chem. 2012 Jun 15;287(25):21471-80. doi: 10.1074/jbc.M112.355354. Epub 2012 Apr 27.


Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.

Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S.

DNA Repair (Amst). 2012 Apr 1;11(4):441-8. doi: 10.1016/j.dnarep.2012.01.006. Epub 2012 Feb 11.


ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M.

EMBO J. 2009 Nov 4;28(21):3413-27. doi: 10.1038/emboj.2009.276. Epub 2009 Sep 24.


The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Goodarzi AA, Jeggo P, Lobrich M.

DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30. Review.


Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Lee JH, Paull TT.

Oncogene. 2007 Dec 10;26(56):7741-8. Review.


H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP.

Nature. 2011 Jan 13;469(7329):245-9. doi: 10.1038/nature09585. Epub 2010 Dec 15. Erratum in: Nature. 2011 Apr 14;472(7342):247.

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