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Results: 1 to 20 of 195

1.

Tsc2-Rheb signaling regulates EphA-mediated axon guidance.

Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M.

Nat Neurosci. 2010 Feb;13(2):163-72. doi: 10.1038/nn.2477. Epub 2010 Jan 10.

PMID:
20062052
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.

PMID:
15772076
[PubMed - indexed for MEDLINE]
Free Article
3.

Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival.

Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T.

Cancer Cell. 2006 Sep;10(3):215-26.

PMID:
16959613
[PubMed - indexed for MEDLINE]
Free Article
4.

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.

Finlay GA, Malhowski AJ, Liu Y, Fanburg BL, Kwiatkowski DJ, Toksoz D.

Cancer Res. 2007 Oct 15;67(20):9878-86.

PMID:
17942919
[PubMed - indexed for MEDLINE]
Free Article
5.

Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.

PMID:
15854902
[PubMed - indexed for MEDLINE]
Free Article
6.

Measurements of TSC2 GAP activity toward Rheb.

Li Y, Inoki K, Vikis H, Guan KL.

Methods Enzymol. 2006;407:46-54.

PMID:
16757313
[PubMed - indexed for MEDLINE]
7.

Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.

Kwiatkowski DJ.

Cancer Biol Ther. 2003 Sep-Oct;2(5):471-6. Review.

PMID:
14614311
[PubMed - indexed for MEDLINE]
Free Article
8.

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.

Miyazaki M, McCarthy JJ, Esser KA.

FEBS J. 2010 May;277(9):2180-91. doi: 10.1111/j.1742-4658.2010.07635.x.

PMID:
20412061
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

Li Y, Inoki K, Guan KL.

Mol Cell Biol. 2004 Sep;24(18):7965-75.

PMID:
15340059
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.

Shah OJ, Wang Z, Hunter T.

Curr Biol. 2004 Sep 21;14(18):1650-6.

PMID:
15380067
[PubMed - indexed for MEDLINE]
Free Article
11.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.

Mol Cell. 2003 Jun;11(6):1457-66.

PMID:
12820960
[PubMed - indexed for MEDLINE]
Free Article
12.

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.

Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M.

J Neurosci. 2009 May 6;29(18):5926-37. doi: 10.1523/JNEUROSCI.0778-09.2009.

PMID:
19420259
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

PMID:
15150271
[PubMed - indexed for MEDLINE]
Free Article
14.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

Nobukini T, Thomas G.

Novartis Found Symp. 2004;262:148-54; discussion 154-9, 265-8. Review.

PMID:
15562827
[PubMed - indexed for MEDLINE]
15.

EphA kinase activation regulates HGF-induced epithelial branching morphogenesis.

Miao H, Nickel CH, Cantley LG, Bruggeman LA, Bennardo LN, Wang B.

J Cell Biol. 2003 Sep 29;162(7):1281-92.

PMID:
14517207
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.

Robb VA, Astrinidis A, Henske EP.

Mod Pathol. 2006 Jun;19(6):839-46. Erratum in: Mod Pathol. 2006 Jun;19(6):889.

PMID:
16575396
[PubMed - indexed for MEDLINE]
Free Article
17.

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Inoki K, Li Y, Xu T, Guan KL.

Genes Dev. 2003 Aug 1;17(15):1829-34. Epub 2003 Jul 17.

PMID:
12869586
[PubMed - indexed for MEDLINE]
Free PMC Article
18.
19.

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8286-91. doi: 10.1073/pnas.0712268105. Epub 2008 Jun 11.

PMID:
18550814
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis.

Makovski V, Haklai R, Kloog Y.

Int J Cancer. 2012 Mar 15;130(6):1420-9. doi: 10.1002/ijc.26139. Epub 2011 Aug 1.

PMID:
21500191
[PubMed - indexed for MEDLINE]

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