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Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

Wu Y, Brodt P, Sun H, Mejia W, Novosyadlyy R, Nunez N, Chen X, Mendoza A, Hong SH, Khanna C, Yakar S.

Cancer Res. 2010 Jan 1;70(1):57-67. doi: 10.1158/0008-5472.CAN-09-2472.


Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D.

Cancer Res. 2002 Feb 15;62(4):1030-5.


Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice.

Ealey KN, Xuan W, Lu S, Archer MC.

Int J Cancer. 2008 Jan 15;122(2):472-6.


Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Hong SH, Briggs J, Newman R, Hoffman K, Mendoza A, LeRoith D, Helman L, Yakar S, Khanna C.

Int J Cancer. 2009 May 1;124(9):2042-9. doi: 10.1002/ijc.24169.


Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers.

Miyamoto S, Nakamura M, Shitara K, Nakamura K, Ohki Y, Ishii G, Goya M, Kodama K, Sangai T, Maeda H, Shi-Chuang Z, Chiba T, Ochiai A.

Clin Cancer Res. 2005 May 1;11(9):3494-502.


Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

Shimizu M, Shirakami Y, Iwasa J, Shiraki M, Yasuda Y, Hata K, Hirose Y, Tsurumi H, Tanaka T, Moriwaki H.

Clin Cancer Res. 2009 May 1;15(9):3068-75. doi: 10.1158/1078-0432.CCR-08-2093. Epub 2009 Apr 14.


Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.


Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver.

Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, Somcio RJ, Lin YG, Lim S, Fan F, Mangala LS, Arumugam T, Logsdon CD, Lopez-Berestein G, Sood AK, Ellis LM.

J Natl Cancer Inst. 2008 Jan 16;100(2):109-20. doi: 10.1093/jnci/djm279. Epub 2008 Jan 8. Erratum in: J Natl Cancer Inst. 2008 Mar 19;100(6):446.


Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer.

Reinmuth N, Fan F, Liu W, Parikh AA, Stoeltzing O, Jung YD, Bucana CD, Radinsky R, Gallick GE, Ellis LM.

Lab Invest. 2002 Oct;82(10):1377-89.


Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice.

Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, Bucana CD, Callahan J, Parry GC, Evans DB, Boyd DD, Mazar AP, Ellis LM.

Cancer Res. 2005 Sep 1;65(17):7775-81.


Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis.

Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.

Cancer Res. 2006 Dec 1;66(23):11263-70.


Cooperation of liver cells in health and disease.

Kmieć Z.

Adv Anat Embryol Cell Biol. 2001;161:III-XIII, 1-151. Review.


Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis.

Badiola I, Olaso E, Crende O, Friedman SL, Vidal-Vanaclocha F.

Gut. 2012 Oct;61(10):1465-72. doi: 10.1136/gutjnl-2011-300810. Epub 2011 Nov 9.

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