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Results: 1 to 20 of 98

1.

CXCR4 acts as a costimulator during thymic beta-selection.

Trampont PC, Tosello-Trampont AC, Shen Y, Duley AK, Sutherland AE, Bender TP, Littman DR, Ravichandran KS.

Nat Immunol. 2010 Feb;11(2):162-70. doi: 10.1038/ni.1830. Epub 2009 Dec 13.

PMID:
20010845
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.

Golec DP, Dower NA, Stone JC, Baldwin TA.

PLoS One. 2013;8(1):e53300. doi: 10.1371/journal.pone.0053300. Epub 2013 Jan 7.

PMID:
23308188
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ.

Int Immunol. 2007 Dec;19(12):1421-30. Epub 2007 Nov 1.

PMID:
17981791
[PubMed - indexed for MEDLINE]
Free Article
4.

Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.

Janas ML, Varano G, Gudmundsson K, Noda M, Nagasawa T, Turner M.

J Exp Med. 2010 Jan 18;207(1):247-61. doi: 10.1084/jem.20091430. Epub 2009 Dec 28.

PMID:
20038597
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes.

Falk I, Biro J, Kohler H, Eichmann K.

J Exp Med. 1996 Dec 1;184(6):2327-39.

PMID:
8976187
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Co-ordinate expression of the pre-T-cell receptor complex and a novel immature thymocyte-specific antigen, IMT-1, during thymocyte development.

Tong JJ, Kishi H, Nagata T, Muraguchi A.

Immunology. 1999 Jan;96(1):48-56.

PMID:
10233677
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A NK1.1+ thymocyte-derived TCR beta-chain transgene promotes positive selection of thymic NK1.1+ alpha beta T cells.

Viret C, Lantz O, He X, Bendelac A, Janeway CA Jr.

J Immunol. 2000 Sep 15;165(6):3004-14.

PMID:
10975809
[PubMed - indexed for MEDLINE]
Free Article
8.

TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling.

Mancini SJ, Candéias SM, Di Santo JP, Ferrier P, Marche PN, Jouvin-Marche E.

J Immunol. 2001 Oct 15;167(8):4485-93.

PMID:
11591775
[PubMed - indexed for MEDLINE]
Free Article
9.

T lymphocyte development in the absence of Fc epsilon receptor I gamma subunit: analysis of thymic-dependent and independent alpha beta and gamma delta pathways.

Heiken H, Schulz RJ, Ravetch JV, Reinherz EL, Koyasu S.

Eur J Immunol. 1996 Aug;26(8):1935-43.

PMID:
8765042
[PubMed - indexed for MEDLINE]
10.

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.

Michie AM, Zúñiga-Pflücker JC.

Semin Immunol. 2002 Oct;14(5):311-23. Review.

PMID:
12220932
[PubMed - indexed for MEDLINE]
11.

Requirement of CD3 complex-associated signaling functions for expression of rearranged T cell receptor beta VDJ genes in early thymic development.

Würch A, Biro J, Potocnik AJ, Falk I, Mossmann H, Eichmann K.

J Exp Med. 1998 Nov 2;188(9):1669-78.

PMID:
9802979
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development.

Lacorazza HD, Tucek-Szabo C, Vasović LV, Remus K, Nikolich-Zugich J.

J Immunol. 2001 Mar 1;166(5):3184-93.

PMID:
11207271
[PubMed - indexed for MEDLINE]
Free Article
13.

The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.

Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ.

PLoS One. 2011;6(6):e20639. doi: 10.1371/journal.pone.0020639. Epub 2011 Jun 3.

PMID:
21673984
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes.

Xiong J, Parker BL, Dalheimer SL, Yankee TM.

Immunology. 2013 Apr;138(4):382-91. doi: 10.1111/imm.12050.

PMID:
23215679
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

Hoffman ES, Passoni L, Crompton T, Leu TM, Schatz DG, Koff A, Owen MJ, Hayday AC.

Genes Dev. 1996 Apr 15;10(8):948-62.

PMID:
8608942
[PubMed - indexed for MEDLINE]
Free Article
16.

The magnitude of thymic output is genetically determined through controlled intrathymic precursor T cell proliferation.

Dulude G, Cheynier R, Gauchat D, Abdallah A, Kettaf N, Sékaly RP, Gratton S.

J Immunol. 2008 Dec 1;181(11):7818-24.

PMID:
19017971
[PubMed - indexed for MEDLINE]
Free Article
17.

The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

Maillard I, Tu L, Sambandam A, Yashiro-Ohtani Y, Millholland J, Keeshan K, Shestova O, Xu L, Bhandoola A, Pear WS.

J Exp Med. 2006 Oct 2;203(10):2239-45. Epub 2006 Sep 11.

PMID:
16966428
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Lunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo.

Visan I, Yuan JS, Liu Y, Stanley P, Guidos CJ.

J Immunol. 2010 Oct 15;185(8):4609-17. doi: 10.4049/jimmunol.1002008. Epub 2010 Sep 15.

PMID:
20844195
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.

Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, Iemura S, Shirai M, Abe T, Natsume T, Sasazuki T, Suzuki H.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16345-50. doi: 10.1073/pnas.0908593106. Epub 2009 Sep 14.

PMID:
19805304
[PubMed - indexed for MEDLINE]
Free PMC Article

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