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Results: 1 to 20 of 101

1.

Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.

Liu C, He X.

J Mol Cell Biol. 2010 Apr;2(2):70-3. doi: 10.1093/jmcb/mjp040. Epub 2009 Dec 11.

PMID:
20008332
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.

Fearon ER.

Cancer Cell. 2009 Nov 6;16(5):366-8. doi: 10.1016/j.ccr.2009.10.007. Review.

PMID:
19878868
[PubMed - indexed for MEDLINE]
Free Article
3.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.

Nature. 2009 Oct 1;461(7264):614-20. doi: 10.1038/nature08356. Epub 2009 Sep 16.

PMID:
19759537
[PubMed - indexed for MEDLINE]
4.

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.

Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S.

Mol Cell Biol. 2011 May;31(10):2053-65. doi: 10.1128/MCB.01094-10. Epub 2011 Mar 7.

PMID:
21383061
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.

James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT.

PLoS One. 2012;7(12):e50457. doi: 10.1371/journal.pone.0050457. Epub 2012 Dec 5.

PMID:
23227175
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Tankyrase is necessary for canonical Wnt signaling during kidney development.

Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ.

Dev Dyn. 2010 Jul;239(7):2014-23. doi: 10.1002/dvdy.22340.

PMID:
20549720
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Evidence for tankyrases as antineoplastic targets in lung cancer.

Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.

BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211.

PMID:
23621985
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L.

Nat Chem Biol. 2009 Feb;5(2):100-7. doi: 10.1038/nchembio.137. Epub 2009 Jan 4.

PMID:
19125156
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

Jiang Y, Luo W, Howe PH.

Oncogene. 2009 Aug 20;28(33):2999-3007. doi: 10.1038/onc.2009.157. Epub 2009 Jul 6.

PMID:
19581931
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, Liu PS, Bheddah S, Tao J, Lill JR, Hongo JA, Davis D, Kirkpatrick DS, Polakis P, Costa M.

PLoS One. 2011;6(7):e22595. doi: 10.1371/journal.pone.0022595. Epub 2011 Jul 25.

PMID:
21799911
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Wnt/beta-catenin signaling: new (and old) players and new insights.

Huang H, He X.

Curr Opin Cell Biol. 2008 Apr;20(2):119-25. doi: 10.1016/j.ceb.2008.01.009. Epub 2008 Mar 12. Review.

PMID:
18339531
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X.

Development. 2008 Jan;135(2):367-75. Epub 2007 Dec 12.

PMID:
18077588
[PubMed - indexed for MEDLINE]
Free Article
13.

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM 3rd, Lee E.

Nat Chem Biol. 2010 Nov;6(11):829-36. doi: 10.1038/nchembio.453. Epub 2010 Oct 3.

PMID:
20890287
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Wnt/beta-catenin signaling: components, mechanisms, and diseases.

MacDonald BT, Tamai K, He X.

Dev Cell. 2009 Jul;17(1):9-26. doi: 10.1016/j.devcel.2009.06.016. Review.

PMID:
19619488
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Drug discovery: Propping up a destructive regime.

Peterson RT.

Nature. 2009 Oct 1;461(7264):599-600. doi: 10.1038/461599a. No abstract available.

PMID:
19794479
[PubMed - indexed for MEDLINE]
16.

Regulation of Wnt/beta-catenin signaling by protein kinases.

Verheyen EM, Gottardi CJ.

Dev Dyn. 2010 Jan;239(1):34-44. doi: 10.1002/dvdy.22019. Review.

PMID:
19623618
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.

Casás-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA Jr, Chan DC, Tan AC, DeGregori J.

Cancer Res. 2012 Aug 15;72(16):4154-64. doi: 10.1158/0008-5472.CAN-11-2848. Epub 2012 Jun 27.

PMID:
22738915
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Targeting the Wnt/β-catenin signaling pathway in human cancers.

Yao H, Ashihara E, Maekawa T.

Expert Opin Ther Targets. 2011 Jul;15(7):873-87. doi: 10.1517/14728222.2011.577418. Epub 2011 Apr 12. Review.

PMID:
21486121
[PubMed - indexed for MEDLINE]
19.

New avenues to target Wnt/β-catenin signaling.

Verkaar F, Zaman GJ.

Drug Discov Today. 2011 Jan;16(1-2):35-41. doi: 10.1016/j.drudis.2010.11.007. Epub 2010 Nov 24. Review.

PMID:
21111060
[PubMed - indexed for MEDLINE]
20.

Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).

Tanneberger K, Pfister AS, Kriz V, Bryja V, Schambony A, Behrens J.

J Biol Chem. 2011 Jun 3;286(22):19204-14. doi: 10.1074/jbc.M111.224881. Epub 2011 Apr 15.

PMID:
21498506
[PubMed - indexed for MEDLINE]
Free PMC Article

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