Similar articles for PMID: 19962665

Year	Number of Results
1997	1
1998	5
1999	3
2000	2
2001	5
2002	9
2003	6
2004	4
2005	9
2006	5
2007	5
2008	8
2009	7
2010	13
2011	1
2012	6
2013	2
2014	4
2015	2
2016	4
2017	7
2018	2
2019	1
2020	3
2021	1
2022	2
2023	3
2024	0

1

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S. Jaiswal BS, et al. Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016. Cancer Cell. 2009. PMID: 19962665 Free PMC article.

2

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Sun M, Hillmann P, Hofmann BT, Hart JR, Vogt PK. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52. doi: 10.1073/pnas.1009652107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713702 Free PMC article.

3

Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Huang CH, Mandelker D, Gabelli SB, Amzel LM. Huang CH, et al. Cell Cycle. 2008 May 1;7(9):1151-6. doi: 10.4161/cc.7.9.5817. Epub 2008 Feb 27. Cell Cycle. 2008. PMID: 18418043 Free PMC article. Review.

4

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.

Dbouk HA, Pang H, Fiser A, Backer JM. Dbouk HA, et al. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19897-902. doi: 10.1073/pnas.1008739107. Epub 2010 Oct 28. Proc Natl Acad Sci U S A. 2010. PMID: 21030680 Free PMC article.

5

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

Dornan GL, Burke JE. Dornan GL, et al. Front Immunol. 2018 Mar 19;9:575. doi: 10.3389/fimmu.2018.00575. eCollection 2018. Front Immunol. 2018. PMID: 29616047 Free PMC article. Review.

6

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL. Miled N, et al. Science. 2007 Jul 13;317(5835):239-42. doi: 10.1126/science.1135394. Science. 2007. PMID: 17626883

7

Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.

Hofmann BT, Jücker M. Hofmann BT, et al. Cell Signal. 2012 Oct;24(10):1950-4. doi: 10.1016/j.cellsig.2012.06.009. Epub 2012 Jun 24. Cell Signal. 2012. PMID: 22735814

8

Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model.

Oliver MD, Fernández-Acero T, Luna S, Rodríguez-Escudero I, Molina M, Pulido R, Cid VJ. Oliver MD, et al. Biosci Rep. 2017 Mar 15;37(2):BSR20160258. doi: 10.1042/BSR20160258. Print 2017 Apr 30. Biosci Rep. 2017. PMID: 28143957 Free PMC article.

9

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.

Shekar SC, Wu H, Fu Z, Yip SC, Nagajyothi, Cahill SM, Girvin ME, Backer JM. Shekar SC, et al. J Biol Chem. 2005 Jul 29;280(30):27850-5. doi: 10.1074/jbc.M506005200. Epub 2005 Jun 2. J Biol Chem. 2005. PMID: 15932879 Free article.

10

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.

Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Wu H, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915146 Free PMC article.

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