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Results: 1 to 20 of 272

1.

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation.

Fernandez-L A, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD, Kenney AM.

Genes Dev. 2009 Dec 1;23(23):2729-41. doi: 10.1101/gad.1824509.

PMID:
19952108
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871. Epub 2008 Aug 28.

PMID:
18755774
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.

Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD.

Cancer Res. 2009 Apr 15;69(8):3249-55. doi: 10.1158/0008-5472.CAN-08-4710. Epub 2009 Apr 7.

PMID:
19351822
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors.

Kenney AM, Cole MD, Rowitch DH.

Development. 2003 Jan;130(1):15-28.

PMID:
12441288
[PubMed - indexed for MEDLINE]
Free Article
5.

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma.

Bhatia B, Potts CR, Guldal C, Choi S, Korshunov A, Pfister S, Kenney AM, Nahlé ZA.

Acta Neuropathol. 2012 Apr;123(4):587-600. doi: 10.1007/s00401-012-0968-6. Epub 2012 Mar 11.

PMID:
22407012
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice.

McCall TD, Pedone CA, Fults DW.

Cancer Res. 2007 Jun 1;67(11):5179-85.

PMID:
17545597
[PubMed - indexed for MEDLINE]
Free Article
7.

p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.

Bhatia B, Malik A, Fernandez-L A, Kenney AM.

Cell Cycle. 2010 Nov 1;9(21):4307-14. Epub 2010 Nov 27.

PMID:
21051932
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth.

Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ, Laterra J, Fults DW.

Cancer Res. 2008 Oct 1;68(19):7838-45. doi: 10.1158/0008-5472.CAN-08-1899.

PMID:
18829539
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.

Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U.

Acta Neuropathol. 2012 Apr;123(4):601-14. doi: 10.1007/s00401-012-0961-0. Epub 2012 Feb 21.

PMID:
22349907
[PubMed - indexed for MEDLINE]
10.

Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma.

Bhatia B, Hsieh M, Kenney AM, Nahlé Z.

Oncogene. 2011 Jan 27;30(4):410-22. doi: 10.1038/onc.2010.454. Epub 2010 Oct 4. Erratum in: Oncogene. 2011 Jan 27;30(4):504.

PMID:
20890301
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.

Elamin MH, Shinwari Z, Hendrayani SF, Al-Hindi H, Al-Shail E, Khafaga Y, Al-Kofide A, Aboussekhra A.

Mol Carcinog. 2010 Mar;49(3):302-14. doi: 10.1002/mc.20604.

PMID:
20025076
[PubMed - indexed for MEDLINE]
12.

Sox2 requirement in sonic hedgehog-associated medulloblastoma.

Ahlfeld J, Favaro R, Pagella P, Kretzschmar HA, Nicolis S, Schüller U.

Cancer Res. 2013 Jun 15;73(12):3796-807. doi: 10.1158/0008-5472.CAN-13-0238. Epub 2013 Apr 17.

PMID:
23596255
[PubMed - indexed for MEDLINE]
Free Article
13.

Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells.

Colvin Wanshura LE, Galvin KE, Ye H, Fernandez-Zapico ME, Wetmore C.

Cancer Res. 2011 Aug 1;71(15):5336-45. doi: 10.1158/0008-5472.CAN-10-2633. Epub 2011 Jun 6.

PMID:
21646478
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Expression of Sonic hedgehog during cell proliferation in the human cerebellum.

Haldipur P, Bharti U, Govindan S, Sarkar C, Iyengar S, Gressens P, Mani S.

Stem Cells Dev. 2012 May 1;21(7):1059-68. doi: 10.1089/scd.2011.0206. Epub 2011 Aug 24.

PMID:
21732818
[PubMed - indexed for MEDLINE]
15.

Double trouble: when sonic hedgehog signaling meets TSC inactivation.

Bhatia B, Nahlé Z, Kenney AM.

Cell Cycle. 2010 Feb 1;9(3):456-9. Epub 2010 Feb 6.

PMID:
20081363
[PubMed - indexed for MEDLINE]
Free Article
16.

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.

Bhatia B, Northcott PA, Hambardzumyan D, Govindarajan B, Brat DJ, Arbiser JL, Holland EC, Taylor MD, Kenney AM.

Cancer Res. 2009 Sep 15;69(18):7224-34. doi: 10.1158/0008-5472.CAN-09-1299. Epub 2009 Sep 8.

PMID:
19738049
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.

Hallahan AR, Pritchard JI, Hansen S, Benson M, Stoeck J, Hatton BA, Russell TL, Ellenbogen RG, Bernstein ID, Beachy PA, Olson JM.

Cancer Res. 2004 Nov 1;64(21):7794-800.

PMID:
15520185
[PubMed - indexed for MEDLINE]
Free Article
18.

Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells.

Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler OD, Schilling K, Pietsch T.

Am J Pathol. 2005 Apr;166(4):1153-62.

PMID:
15793295
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.

Browd SR, Kenney AM, Gottfried ON, Yoon JW, Walterhouse D, Pedone CA, Fults DW.

Cancer Res. 2006 Mar 1;66(5):2666-72.

PMID:
16510586
[PubMed - indexed for MEDLINE]
Free Article
20.

Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.

Weiner HL, Bakst R, Hurlbert MS, Ruggiero J, Ahn E, Lee WS, Stephen D, Zagzag D, Joyner AL, Turnbull DH.

Cancer Res. 2002 Nov 15;62(22):6385-9.

PMID:
12438220
[PubMed - indexed for MEDLINE]
Free Article

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