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Items: 1 to 20 of 157

1.

Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease.

Fernández-Gamba A, Leal MC, Morelli L, Castaño EM.

Curr Pharm Des. 2009;15(31):3644-55. Review.

PMID:
19925417
2.

The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective.

de Tullio MB, Morelli L, Castaño EM.

Prion. 2008 Apr-Jun;2(2):51-6. Epub 2008 May 1. Review.

3.

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.

Llovera RE, de Tullio M, Alonso LG, Leissring MA, Kaufman SB, Roher AE, de Prat Gay G, Morelli L, Castaño EM.

J Biol Chem. 2008 Jun 20;283(25):17039-48. doi: 10.1074/jbc.M706316200. Epub 2008 Apr 14.

4.
5.

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.

J Biol Chem. 1998 Dec 4;273(49):32730-8.

6.

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.

7.

Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.

Guo Q, Manolopoulou M, Bian Y, Schilling AB, Tang WJ.

J Mol Biol. 2010 Jan 15;395(2):430-43. doi: 10.1016/j.jmb.2009.10.072. Epub 2009 Nov 5.

8.

Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

Song ES, Juliano MA, Juliano L, Hersh LB.

J Biol Chem. 2003 Dec 12;278(50):49789-94. Epub 2003 Oct 2.

9.
10.

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

Qiu WQ, Folstein MF.

Neurobiol Aging. 2006 Feb;27(2):190-8. Epub 2005 Feb 17. Review.

PMID:
16399206
11.

Degradation of amylin by insulin-degrading enzyme.

Bennett RG, Duckworth WC, Hamel FG.

J Biol Chem. 2000 Nov 24;275(47):36621-5.

12.

Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex.

Bennett RG, Hamel FG, Duckworth WC.

Diabetes. 1997 Feb;46(2):197-203. Erratum in: Diabetes 1997 Sep;46(9):1532.

PMID:
9000694
13.

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.

J Neurosci. 2000 Mar 1;20(5):1657-65.

14.

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation.

Cordes CM, Bennett RG, Siford GL, Hamel FG.

Biochem Pharmacol. 2009 Mar 15;77(6):1064-73. doi: 10.1016/j.bcp.2008.12.006. Epub 2008 Dec 27.

PMID:
19154729
15.

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity.

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M.

J Mol Biol. 2009 Feb 6;385(5):1556-67. doi: 10.1016/j.jmb.2008.11.025. Epub 2008 Nov 25.

PMID:
19073193
16.

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.

McCord LA, Liang WG, Dowdell E, Kalas V, Hoey RJ, Koide A, Koide S, Tang WJ.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13827-32. doi: 10.1073/pnas.1304575110. Epub 2013 Aug 6.

17.

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.

Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.

Biochemistry. 2005 May 3;44(17):6513-25.

PMID:
15850385
18.

Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.

Morelli L, Llovera RE, Mathov I, Lue LF, Frangione B, Ghiso J, Castaño EM.

J Biol Chem. 2004 Dec 31;279(53):56004-13. Epub 2004 Oct 15.

19.

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.

Çakir B, Dağliyan O, Dağyildiz E, Bariş İ, Kavakli IH, Kizilel S, Türkay M.

PLoS One. 2012;7(2):e31787. doi: 10.1371/journal.pone.0031787. Epub 2012 Feb 15.

20.

Molecular basis for the thiol sensitivity of insulin-degrading enzyme.

Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9582-7. doi: 10.1073/pnas.0801261105. Epub 2008 Jul 8.

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