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Results: 1 to 20 of 136

1.

Gating of nicotinic ACh receptors: latest insights into ligand binding and function.

Yakel JL.

J Physiol. 2010 Feb 15;588(Pt 4):597-602. doi: 10.1113/jphysiol.2009.182691. Epub 2009 Nov 16. Review.

PMID:
19917567
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening.

Gay EA, Yakel JL.

J Physiol. 2007 Nov 1;584(Pt 3):727-33. Epub 2007 Sep 6. Review.

PMID:
17823204
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Recent advances in understanding the structure of nicotinic acetylcholine receptors.

Zouridakis M, Zisimopoulou P, Poulas K, Tzartos SJ.

IUBMB Life. 2009 Apr;61(4):407-23. doi: 10.1002/iub.170. Review.

PMID:
19319967
[PubMed - indexed for MEDLINE]
4.
5.

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK.

Nature. 2001 May 17;411(6835):269-76.

PMID:
11357122
[PubMed - indexed for MEDLINE]
6.

Multiple interaction regions in the orthosteric ligand binding domain of the α7 neuronal nicotinic acetylcholine receptor.

Xiao Y, Hammond PS, Mazurov AA, Yohannes D.

J Chem Inf Model. 2012 Nov 26;52(11):3064-73. doi: 10.1021/ci3001953. Epub 2012 Nov 6.

PMID:
23092444
[PubMed - indexed for MEDLINE]
7.

Identification of two critical residues within the Cys-loop sequence that determine fast-gating kinetics in a pentameric ligand-gated ion channel.

Grutter T, de Carvalho LP, Dufresne V, Taly A, Changeux JP.

J Mol Neurosci. 2006;30(1-2):63-4.

PMID:
17192629
[PubMed - indexed for MEDLINE]
8.

Structure and function of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

Smit AB, Brejc K, Syed N, Sixma TK.

Ann N Y Acad Sci. 2003 Sep;998:81-92. Review.

PMID:
14592865
[PubMed - indexed for MEDLINE]
9.

Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica.

Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Bourne Y, Taylor P.

J Mol Neurosci. 2006;30(1-2):101-2.

PMID:
17192647
[PubMed - indexed for MEDLINE]
10.

Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors.

Tsetlin V, Utkin Y, Kasheverov I.

Biochem Pharmacol. 2009 Oct 1;78(7):720-31. doi: 10.1016/j.bcp.2009.05.032. Epub 2009 Jun 6. Review.

PMID:
19501053
[PubMed - indexed for MEDLINE]
11.

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

Sixma TK, Smit AB.

Annu Rev Biophys Biomol Struct. 2003;32:311-34. Epub 2003 Feb 21. Review.

PMID:
12695308
[PubMed - indexed for MEDLINE]
12.

Effect of homologous serotonin receptor loop substitutions on the heterologous expression in Pichia of a chimeric acetylcholine-binding protein with alpha-bungarotoxin-binding activity.

Paulo JA, Hawrot E.

Protein Expr Purif. 2009 Oct;67(2):76-81. doi: 10.1016/j.pep.2009.05.001. Epub 2009 May 8.

PMID:
19427904
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop.

Wiltfong RE, Jansen M.

J Neurosci. 2009 Feb 11;29(6):1626-35. doi: 10.1523/JNEUROSCI.4121-08.2009.

PMID:
19211870
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

Brejc K, van Dijk WJ, Smit AB, Sixma TK.

Novartis Found Symp. 2002;245:22-9; discussion 29-32, 165-8. Review.

PMID:
12027010
[PubMed - indexed for MEDLINE]
15.

Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.

Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz Á, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV.

J Am Chem Soc. 2012 Apr 18;134(15):6732-40. doi: 10.1021/ja3001858. Epub 2012 Apr 6.

PMID:
22394239
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Modeling neuronal nicotinic and GABA receptors: important interface salt-links and protein dynamics.

Law RJ, Lightstone FC.

Biophys J. 2009 Sep 16;97(6):1586-94. doi: 10.1016/j.bpj.2009.06.044.

PMID:
19751663
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Positive and negative modulation of nicotinic receptors.

Arias HR.

Adv Protein Chem Struct Biol. 2010;80:153-203. doi: 10.1016/B978-0-12-381264-3.00005-9. Review.

PMID:
21109220
[PubMed - indexed for MEDLINE]
18.

Assembly of nicotinic and other Cys-loop receptors.

Tsetlin V, Kuzmin D, Kasheverov I.

J Neurochem. 2011 Mar;116(5):734-41. doi: 10.1111/j.1471-4159.2010.07060.x. Epub 2011 Jan 13. Review.

PMID:
21214570
[PubMed - indexed for MEDLINE]
19.

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions.

Lee WY, Free CR, Sine SM.

J Neurosci. 2009 Mar 11;29(10):3189-99. doi: 10.1523/JNEUROSCI.6185-08.2009.

PMID:
19279256
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors.

Cheng X, Wang H, Grant B, Sine SM, McCammon JA.

PLoS Comput Biol. 2006 Sep 29;2(9):e134. Epub 2006 Aug 23.

PMID:
17009865
[PubMed - indexed for MEDLINE]
Free PMC Article

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